2-Chloro-6-cyanopyridine
- Product Name
- 2-Chloro-6-cyanopyridine
- CAS No.
- 33252-29-8
- Chemical Name
- 2-Chloro-6-cyanopyridine
- Synonyms
- oro-6-Cyanopyridine;2-Cyno-6-chloropyridine;6-CHLOROPICOLINONITRILE;6-CHLORO-2-CYANOPYRIDINE;2-CHLORO-6-CYANOPYRIDINE;2-Cyano-6-chloropyridine;2-Chloro-6-pyridinenitrile;P-1002-Chloro-6-Cyanopyridine;6-Chloropyridin-2-carbonitrile;6-CHLOROPYRIDINE-2-CARBONITRILE
- CBNumber
- CB3423721
- Molecular Formula
- C6H3ClN2
- Formula Weight
- 138.55
- MOL File
- 33252-29-8.mol
2-Chloro-6-cyanopyridine Property
- Melting point:
- 85-89 °C
- Boiling point:
- 245.3±20.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder
- pka
- -5.77±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C6H3ClN2/c7-6-3-1-2-5(4-8)9-6/h1-3H
- InChIKey
- PGZHSVWXFKKCNR-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC(Cl)=CC=C1
- CAS DataBase Reference
- 33252-29-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-36/37/39-37
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 665967
- Product name
- 6-Chloropyridine-2-carbonitrile
- Purity
- 96%
- Packaging
- 1g
- Price
- $121
- Updated
- 2023/06/20
- Product number
- 665967
- Product name
- 6-Chloropyridine-2-carbonitrile
- Purity
- 96%
- Packaging
- 5g
- Price
- $396
- Updated
- 2023/06/20
- Product number
- C380765
- Product name
- 2-Chloro-6-cyanopyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- C380765
- Product name
- 2-Chloro-6-cyanopyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 018357
- Product name
- 2-Chloro-6-cyanopyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-Chloro-6-cyanopyridine Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
Substrate used in a Negishi coupling reaction with an arylzinc halide catalyzed by Pd-NHC (PEPPSI-Ipr, Catalog No. 668032).
Synthesis
773837-37-9
87512-29-6
33252-29-8
The reaction was carried out with 2-chloro-6-(methylsulfonyl)pyridine (13.0 g, 67.8 mmol) and sodium cyanide (6.69 g, 136 mmol) in DMF (150 ml) with stirring at 170°C for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography with the eluent petroleum ether-ethyl acetate (2:1, v/v) to afford 2-chloro-6-cyanopyridine (6.67 g, 71% yield) as white crystals with a melting point of 82.9-83.1 °C. IR (KBr, cm-1): 2253 (CN), 1572, 1431, 1161. 1143, 912, 854, 744. 1H-NMR (CDCl3, δ): 7.57 (1H, d, J = 8.0 Hz), 7.65 (1H, d, J = 8.1 Hz), 7.82 (1H, t, J = 7.8 Hz).
References
[1] Patent: EP1424336, 2004, A1. Location in patent: Page 41
2-Chloro-6-cyanopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-cyanopyridine manufacturers
- Product
- 2-Chloro-6-cyanopyridine 33252-29-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-14
- Product
- 2-Chloro-6-cyanopyridine 33252-29-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-Chloro-6-cyanopyridine 33252-29-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-20