2-Chloro-4-fluorotoluene
- Product Name
- 2-Chloro-4-fluorotoluene
- CAS No.
- 452-73-3
- Chemical Name
- 2-Chloro-4-fluorotoluene
- Synonyms
- 2-CHLORO-4-FLUORO-1-METHYLBENZENE;oro-4-fL;2-CHLORO-3-FLUOROTOLU;2-Chlor-4-fluortoluol;2-CHLORO-4-FLUOROTOLUENE;4-FLUORO-2-CHLOROTOLUENE;2-Chloro-4-fluorotoluene 98%;2-Chloro-4-fluorotoluene,98%;2-Chloro-4-fluorotoluene >3-Chloro-4-methylphenyl fluoride
- CBNumber
- CB3425745
- Molecular Formula
- C7H6ClF
- Formula Weight
- 144.57
- MOL File
- 452-73-3.mol
2-Chloro-4-fluorotoluene Property
- Boiling point:
- 154-156 °C (lit.)
- Density
- 1.197 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.499(lit.)
- Flash point:
- 122 °F
- storage temp.
- 2-8°C
- form
- clear liquid
- color
- Colorless to Light yellow
- Specific Gravity
- 1.197
- BRN
- 1931690
- InChI
- InChI=1S/C7H6ClF/c1-5-2-3-6(9)4-7(5)8/h2-4H,1H3
- InChIKey
- CSARJIQZOSVYHA-UHFFFAOYSA-N
- SMILES
- C1(C)=CC=C(F)C=C1Cl
- CAS DataBase Reference
- 452-73-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Chloro-4-fluorotoluene(452-73-3)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36/37/39-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant/Flammable
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C1227
- Product name
- 2-Chloro-4-fluorotoluene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- C1227
- Product name
- 2-Chloro-4-fluorotoluene
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $263
- Updated
- 2025/07/31
- Product number
- 80730
- Product name
- 2-Chloro-4-fluorotoluene
- Purity
- TraceCERT , certified reference material, 19F-qNMR Standard
- Packaging
- 500mg
- Price
- $148
- Updated
- 2025/07/31
- Product number
- C367205
- Product name
- 2-Chloro-4-fluorotolueneC
- Packaging
- 100g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 001597
- Product name
- 2-Chloro-4-fluorotoluene
- Purity
- 99%
- Packaging
- 1kg
- Price
- $144
- Updated
- 2021/12/16
2-Chloro-4-fluorotoluene Chemical Properties,Usage,Production
Chemical Properties
colorless to light yellow liqui
Uses
2-Chloro-4-fluorotoluene has been used in the preparation of 2-chloro-4-fluoro-benzylbromide.
General Description
2-Chloro-4-fluorotoluene generates vibronically excited, jet-cooled benzyl-type radicals by corona excited supersonic expansion coupled with a pinhole-type glass nozzle technique.
Synthesis
95-74-9
452-73-3
1. In a 1 L reactor (equipped with a condenser and a gas phase outlet diameter of 1/6 to 1/5 the diameter of the reactor), reduce the temperature to 20°C or lower. Slowly add 424 g (21.2 mol, 20 equiv.) of anhydrous hydrogen fluoride under stirring conditions, and further reduce the temperature after the addition is complete. 2. 150 g (1.059 mol, 1 eq.) of 3-chloro-4-methylaniline was added dropwise at 5 °C or lower, with the dropwise acceleration controlled to maintain the reaction temperature in the range of 5 to 15 °C, and the final addition was completed at about 3 °C. 3. after completion of the spiking, the temperature was lowered to 5 °C or lower, 73.1 g (1.06 mol, 1 eq.) of sodium nitrite was added in batches, and the reaction temperature was controlled to be in the range of -5 to 15 °C for 4 hours, followed by a heat hold for 1 hour. 4. Upon completion of the reaction, the reactor was programmed to warm up (strictly control the rate of warming: 0.5 to 1 °C per hour in the range of 0 to 20 °C; 1 to 2 °C per hour in the range of 20 to 80 °C), and was finally warmed up to 80 °C and held for 2 hours. 5. At the end of the holding time, reduce the temperature to 30 to 35°C and leave to stratify. The organic layer was neutralized to pH 7-8 with a dilute alkaline solution, followed by hydrodistillation. 6. 141 g of the organic layer at room temperature was collected and purity was 93.4% by gas chromatography. By distillation 125.1 g of the target product 2-chloro-4-fluorotoluene was obtained in 81.8% yield and 99.9% purity by gas chromatography.
References
[1] Patent: CN108569948, 2018, A. Location in patent: Paragraph 0035-0059
2-Chloro-4-fluorotoluene Preparation Products And Raw materials
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View Lastest Price from 2-Chloro-4-fluorotoluene manufacturers
- Product
- 2-Chloro-4-fluorotoluene 452-73-3
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 100 Tons
- Release date
- 2025-04-27
- Product
- 2-Chloro-4-fluorotoluene 452-73-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-13
- Product
- 2-Chloro-4-fluorotoluene 452-73-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 50mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-08