6-FLUORO (1H)INDAZOLE
- Product Name
- 6-FLUORO (1H)INDAZOLE
- CAS No.
- 348-25-4
- Chemical Name
- 6-FLUORO (1H)INDAZOLE
- Synonyms
- uoro-1H-indazoL;6-Fluoroindazol;6-Fluoroindazole;6-Fluoro (1H)indazol;6-FLUORO (1H)INDAZOLE;1H-Indazole, 6-fluoro-
- CBNumber
- CB3430374
- Molecular Formula
- C7H5FN2
- Formula Weight
- 136.13
- MOL File
- 348-25-4.mol
6-FLUORO (1H)INDAZOLE Property
- Melting point:
- 126 °C (decomp)
- Boiling point:
- 274.9±13.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.21±0.40(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F595483
- Product name
- 6-Fluoro-1H-indazole
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC49002
- Product name
- 6-Fluoro-1H-indazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- PC49002
- Product name
- 6-Fluoro-1H-indazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 3H31-3-Z0
- Product name
- 6-Fluoro-1H-indazole
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- W5643
- Product name
- 6-Fluoro-1H-indazole
- Packaging
- 5g
- Price
- $163
- Updated
- 2021/12/16
6-FLUORO (1H)INDAZOLE Chemical Properties,Usage,Production
Uses
6-Fluoro-1H-indazole
Synthesis
367-29-3
348-25-4
5-Fluoro-2-methylaniline (3 g, 0.024 mol) was used as a raw material, mixed with potassium acetate (2.8 g, 0.028 mol) and acetic anhydride (6.8 mL, 0.072 mol) in chloroform (30 mL), and heated for 0.5 hours at 40 °C. Subsequently, isovaleric acid nitrate (3.8 mL, 0.028 mol) was added at the same temperature and the reaction mixture was warmed to 80 °C and left to react for 12 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was alkalized with aqueous sodium carbonate and extracted with ethyl acetate. The organic layer was washed with water and brine sequentially and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: 30% ethyl acetate/hexane) to obtain the pure compound. The pure compound was treated with methanolic hydrochloric acid solution (60 mL) for 30 min, and the reaction mixture was concentrated under reduced pressure, alkalized with aqueous sodium carbonate, and extracted again with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by column chromatography (eluent: n-hexane/ethyl acetate=7:3) to give 6-fluoroindazole (2.0 g, 62% yield) as a light yellow solid.
References
[1] Patent: WO2015/104662, 2015, A1. Location in patent: Page/Page column 37; 38
[2] Patent: US2016/326151, 2016, A1. Location in patent: Paragraph 0206
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 4, p. 1966 - 1982
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 11, p. 3177 - 3180
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2115 - 2137
6-FLUORO (1H)INDAZOLE Preparation Products And Raw materials
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View Lastest Price from 6-FLUORO (1H)INDAZOLE manufacturers
- Product
- 6-Fluoroindazole 348-25-4
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 6-Fluoroindazole 348-25-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 6-FLUORO (1H)INDAZOLE 348-25-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01