5-Bromo-2-fluorobenzonitrile

Product Name: 5-Bromo-2-fluorobenzonitrile
CAS No.: 179897-89-3
Chemical Name: 5-Bromo-2-fluorobenzonitrile
Synonyms: 2-Fluoro-5-bromobenzonitrile;Olapali impurity 6;Olapali impurity 17;2- fluorine-5-broMoxynil;5-BROMO-2-FLUOROBENZONITRILE;2-Flouro-5-bromobenzonitrile;2-Fliuoro-5-broMo Benzonitrile;Benzonitrile, 5-broMo-2-fluoro-;5-Bromo-2-fluorobenzonitrile98%;5-Bromo-2-fluorobenzonitrile >
CBNumber: CB3431412
Molecular Formula: C7H3BrFN
Formula Weight: 200.01
MOL File: 179897-89-3.mol

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5-Bromo-2-fluorobenzonitrile Property

Melting point:: 76-81 °C
Boiling point:: 220.4±20.0 °C(Predicted)
Density: 1.7286 (rough estimate)
refractive index: 1.5320 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow to Light orange
BRN: 7701063
InChI: InChI=1S/C7H3BrFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H
InChIKey: GYCNHFWRPJXTSB-UHFFFAOYSA-N
SMILES: C(#N)C1=CC(Br)=CC=C1F
CAS DataBase Reference: 179897-89-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 36/37/39-26-22-36
RIDADR: 3439
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 465259
Product name: 5-Bromo-2-fluorobenzonitrile
Purity: 97%
Packaging: 5g
Price: $18.72
Updated: 2024/03/01

Sigma-Aldrich

Product number: 465259
Product name: 5-Bromo-2-fluorobenzonitrile
Purity: 97%
Packaging: 1g
Price: $28.6
Updated: 2023/06/20

TCI Chemical

Product number: B2425
Product name: 5-Bromo-2-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: B2425
Product name: 5-Bromo-2-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $113
Updated: 2024/03/01

Alfa Aesar

Product number: A16113
Product name: 5-Bromo-2-fluorobenzonitrile, 98%
Packaging: 5g
Price: $44.65
Updated: 2024/03/01

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5-Bromo-2-fluorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder or crystals

Uses

5-Bromo-2-fluorobenzonitrile may be used for the preparation of the following compounds:

(E)-5-(2-cyclopropylvinyl)-2-fluorobenzonitrile and methyl-3-amino-5-bromobenzo[b]thiophene-2-carboxylate
(S)-[2-[5-(3-cyano-4-fluoro-phenyl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester
4-fluoro-3-cyano-3′-tributyltinbenzhydrol
4-fluoro-3-cyano-3′-iodobenzhydrol

Synthesis

5-Bromo-2-fluorobenzonitrile is the key intermediate of the synthetic antigout drug Febuxostat. The synthesis method comprises the following steps: reacting o-fluorobenzoyl chloride with ammonia water to obtain o-fluorobenzamide; then generating o-fluorobenzonitrile under the action of a dehydration reagent; and finally, in 75-90% sulfuric acid, brominating with dibromohydantoin to obtain 5-bromo-2-fluorobenzonitrile. The synthesis method is simple and easy to implement, mild in conditions, low in production cost, and causes no wastewater discharge.

5-Bromo-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

2-MERCAPTOPYRIMIDINE-4,6-DIOL

Preparation Products

3-Cyano-4-fluorobenzeneboronic acid

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5-Bromo-2-fluorobenzonitrile Suppliers

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View Lastest Price from 5-Bromo-2-fluorobenzonitrile manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 5-Bromo-2-fluorobenzonitrile 179897-89-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Bromo-2-fluorobenzonitrile 179897-89-3
Price: US $10.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-21

PNP Biotech Co. Ltd

Product: 5-Bromo-2-fluorobenzonitrile 179897-89-3
Price: US $0.00/KG
Min. Order: 25KG
Purity: 95%
Supply Ability: Inquiry
Release date: 2022-09-22

179897-89-3, 5-Bromo-2-fluorobenzonitrileRelated Search:

4-Fluorobenzonitrile 5-Bromo-2-fluorobenzaldehyde 2-Bromobenzonitrile Benzonitrile 4-Bromofluorobenzene 4-Bromobenzonitrile Bromoxynil Chlorfenapyr Florfenicol 1,3-Difluorobenzene DBDCB Bromoxynil octanoate Transfluthrin 5-bromo-3-fluorobenzonitrile 2-Fluorobenzonitrile 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one PIPERAZINE DIHYDROCHLORIDE 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Benzonitrile, 5-broMo-2-fluoro-

2- fluorine-5-broMoxynil

2-Fliuoro-5-broMo Benzonitrile

5-Bromo-2-fluorobenzonitrile,97%

5-BROMO-2-FLUOROBENZONITRILE

2-Fluoro-5-bromobenzonitrile

5-Bromo-2-fluorobenzonitrile 98%

5-Bromo-2-fluorobenzonitrile98%

5-Bromo-2-fluorobenzonitrile &gt

5-Bromo-2-fluorobenzonitrile (Olaparib Impurity)

Olapali impurity 6

Olapali impurity 17

2-Flouro-5-bromobenzonitrile

179897-89-3

Cyanides/Nitriles

Organic Building Blocks

Nitrogen Compounds

ARYL HALIDE

Building Blocks

C6 to C7

cyanide| alkyl bromide| alkyl Fluorine

Fluorine series

Febuxostat

Aromatic Nitriles

Nitrile

Miscellaneous

Bromine Compounds

Fluorine Compounds

Nitriles

C6 to C7

Cyanides/Nitriles

Nitrogen Compounds

Fluorobenzene