GW9662

Product Name: GW9662
CAS No.: 22978-25-2
Chemical Name: GW9662
Synonyms: 2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE;GW9662;CS-762;GW9662, >=98%;GW9662; GW 9662;GW9662 USP/EP/BP;TIMTEC-BB SBB006523;2-CHLORO-5-NITROBENZANILIDE;2-Chloro-5-nitrobenzanilide 97%;GW9662;GW 9662;TIMTEC-BB SBB006523
CBNumber: CB3431922
Molecular Formula: C13H9ClN2O3
Formula Weight: 276.68
MOL File: 22978-25-2.mol

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GW9662 Property

Melting point:: 158-159 °C (lit.)
Boiling point:: 360.9±32.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 26 mg/mL, soluble
form: solid
pka: 11.77±0.70(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: DNTSIBUQMRRYIU-UHFFFAOYSA-N
CAS DataBase Reference: 22978-25-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36-43
Safety Statements: 26-36/37-24/25-22
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6191
Product name: GW 9662
Purity: >98% (HPLC)
Packaging: 5mg
Price: $90.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 642355
Product name: 2-Chloro-5-nitrobenzanilide
Purity: 97%
Packaging: 25g
Price: $282
Updated: 2023/01/07

Alfa Aesar

Product number: J65634
Product name: GW 9662
Packaging: 10mg
Price: $108.65
Updated: 2024/03/01

Alfa Aesar

Product number: J65634
Product name: GW 9662
Packaging: 50mg
Price: $406
Updated: 2021/12/16

Cayman Chemical

Product number: 70785
Product name: GW 9662
Purity: ≥98%
Packaging: 1mg
Price: $12
Updated: 2024/03/01

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GW9662 Chemical Properties,Usage,Production

Description

GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).1 Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM).2 Displays anticancer activity inhibits growth of human mammary tumor cell lines.3 GW-9662 is a useful tool for dissecting the involvement of PPARγ in cellular physiology.4,5

Chemical Properties

Off-White Solid

Uses

An irreversible PPAR antagonist

Uses

GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.

Uses

A cell-permeable, selective and irreversible PPAR antagonist (IC50 = 3.3 nM, 32 nM, and 2 for PPAR, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 , also

Definition

ChEBI: GW 9662 is a member of benzamides.

Biological Activity

Selective PPAR γ antagonist (IC 50 values are 3.3, 32 and 2000 nM for PPAR γ , PPAR α and PPAR δ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μ M), therefore is more potent than BADGE (2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane ). Anticancer, inhibits growth of human mammary tumor cell lines.

Biochem/physiol Actions

GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.

storage

Store at RT

References

1) Leesnitzer et al. (2002), Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662; Biochemistry, 41 6640 2) Bendixen et al. (2001), IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1; Proc. Natl. Acad. Sci. USA, 98 2443 3) Seargent et al. (2004), GW9662, a potent antagonist of PPARgamma inhibits growth of breast cancer tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation; Br. J. Pharmacol., 143 933 4) Cheng et al. (2014), β-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway; Pharmacology, 94 1 5) Liu et al. (2014), Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated-γ function; J. Neuro. Sci. Res., 92 1549

GW9662 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW9662 Suppliers

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View Lastest Price from GW9662 manufacturers

Career Henan Chemical Co

Product: GW9662 22978-25-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

22978-25-2, GW9662Related Search:

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GW9662;GW 9662;TIMTEC-BB SBB006523

GW9662 - CAS 22978-25-2 - Calbiochem

CS-762

GW9662; GW 9662

GW9662, >=98%

2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE

2-CHLORO-5-NITROBENZANILIDE

GW9662

TIMTEC-BB SBB006523

2-Chloro-5-nitro-N-4-phenylbenzamide

BenzaMide,2-chloro-5-nitro-N-phenyl-

N-[(2-chloro-5-nitrophenyl)-phenylmethylidene]hydroxylamine

2-Chloro-5-nitrobenzanilide 97%

GW9662 USP/EP/BP

GW9662,Peroxisome proliferator-activated receptors,PPAR,GW-9662,Inhibitor,inhibit

22978-25-2

C13H19N2O3Cl

ClC6H3NO2CONHC6H5

Gene Regulation and Expression

Organic Building Blocks

PPAR and RXR Regulators

Building Blocks

Amides

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Carbonyl Compounds

Inhibitor

Intracellular receptor

Inhibitors

Amides

Carbonyl Compounds

Organic Building Blocks