Synthesis Preparation Description
ChemicalBook > CAS DataBase List > 2,3,5,6-Tetrafluoropyridine

2,3,5,6-Tetrafluoropyridine

Synthesis Preparation Description
Product Name
2,3,5,6-Tetrafluoropyridine
CAS No.
2875-18-5
Chemical Name
2,3,5,6-Tetrafluoropyridine
Synonyms
2,3,5,6-TetrafL;2,3,5,6-TETRAFLUOROPYRIDINE;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;2,3,5,6-Tetrafluoropyridine 98%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
CBNumber
CB3444784
Molecular Formula
C5HF4N
Formula Weight
151.06
MOL File
2875-18-5.mol
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2,3,5,6-Tetrafluoropyridine Property

Boiling point:
102 °C (lit.)
Density 
1.499 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4046(lit.)
Flash point:
87 °F
storage temp. 
Inert atmosphere,2-8°C
pka
-10.94±0.20(Predicted)
form 
clear liquid
color 
Colorless to Light yellow
Specific Gravity
1.52
InChI
InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
InChIKey
HWIPMBCMGVXOKN-UHFFFAOYSA-N
SMILES
C1(F)=NC(F)=C(F)C=C1F
CAS DataBase Reference
2875-18-5(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5)
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Safety

Hazard Codes 
Xi,F,C
Risk Statements 
10-36/37/38
Safety Statements 
28-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Flammable/Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
316679
Product name
2,3,5,6-Tetrafluoropyridine
Purity
95%
Packaging
1g
Price
$65.2
Updated
2023/06/20
TCI Chemical
Product number
T1778
Product name
2,3,5,6-Tetrafluoropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
T1778
Product name
2,3,5,6-Tetrafluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$144
Updated
2024/03/01
Alfa Aesar
Product number
B21905
Product name
2,3,5,6-Tetrafluoropyridine, 97%
Packaging
1g
Price
$41.1
Updated
2021/12/16
Alfa Aesar
Product number
B21905
Product name
2,3,5,6-Tetrafluoropyridine, 97%
Packaging
5g
Price
$140
Updated
2021/12/16
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2,3,5,6-Tetrafluoropyridine Chemical Properties,Usage,Production

Synthesis

Catalytic reduction of aryl chlorides, bromides and iodides is well documented, however, aryl fluorides do not readily react under these conditions, owing to the strong C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6- tetrafluoropyridine using a palladium catalyst.

Preparation

An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g,  118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for  48 h. The mixture was added to water and extracted into ether. The ether solution was  shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by  comparison of their GCMS and fluorine nmr spectra with authentic samples.  

Description

Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.

Chemical Properties

clear colorless liquid

2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,5,6-Tetrafluoropyridine Suppliers

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View Lastest Price from 2,3,5,6-Tetrafluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Henan Fengda Chemical Co., Ltd
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $5.00-0.20/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-02
LY Global chemicals co.,ltd .
Product
2,3,5,6-Tetrafluoropyridine 2875-18-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%Min
Supply Ability
1000kg
Release date
2023-03-14

2875-18-5, 2,3,5,6-TetrafluoropyridineRelated Search:

Dimefluthrin 1,1,1,2-Tetrafluoroethane 4-Methyl-2,3,5,6-tetrafluoropyridine 99%+ 4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE,4-BROMO-2,3,5,6-TETRAFLUOROPYRIDINE 98% 4-CYANO-2,3,5,6-TETRAFLUOROPYRIDINE,2,3,5,6-Tetrafluoropyridine-4-carbonitrile Pentafluoropyridine 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,4,5-Tetrafluoropyridine 2,3,4,6-TETRAFLUOROPYRIDINE, 98+%,2,3,4,6-TETRAFLUOROPYRIDINE 2,3,5,6-TETRAFLUOROPYRIDINE-4-PROPIONIC ACID 3-Chloro-2,4,5,6-tetrafluoropyridine 2,3,5,6-TETRAFLUOROPYRIDINE-4-CARBOXYLIC ACID 4-HYDROXY-2,3,5,6-TETRAFLUOROPYRIDINE 4-HYDRAZINO-2,3,5,6-TETRAFLUOROPYRIDINE 2,3,5,6-TETRAFLUORO-4-NITROPYRIDINE (2,3,5,6-TETRAFLUORO-4-PYRIDINYL)ACETIC ACID 4-CHLORO-2,3,5,6-TETRAFLUOROPYRIDINE

  • 2,3,5,6-TETRAFLUOROPYRIDINE
  • 2,3,5,6-Tetrafluoropyridine 98%
  • 2,3,5,6-Tetrafluoropyridine98%
  • 2,3,5,6-Tetrafluoropyridine,99%
  • N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &
  • Pyridine,2,3,5,6-tetrafluoro-
  • 2,3,5,6-TetrafL
  • 2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
  • 2875-18-5
  • 2875-18-8
  • C5HF4N
  • Fluoropyridines
  • C5
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halopyridines
  • Fluorine series
  • Pyridine
  • Heterocyclic Compounds
  • Fluoropyridines
  • Halopyridines
  • C5
  • Heterocyclic Building Blocks
  • Pyridines