Synthesis
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Pentafluoropyridine

Synthesis
Product Name
Pentafluoropyridine
CAS No.
700-16-3
Chemical Name
Pentafluoropyridine
Synonyms
PERFLUOROPYRIDINE;PENTAFLUOROPYRIDINE;Pentafluoropyridine>Pentafluoropyridine 99%;5-Chloro-2-caynopyridine;PENTAFLUOROPYRIDINE, 99+%;2,3,4,5,6-Perfluoropyridine;2,3,4,5,6-PENTAFLUOROPYRIDINE;Pentafluoropyridine, 99+% 5GR;Pyridine, 2,3,4,5,6-pentafluoro-
CBNumber
CB2344607
Molecular Formula
C5F5N
Formula Weight
169.05
MOL File
700-16-3.mol
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Pentafluoropyridine Property

Melting point:
-42
Boiling point:
83-85 °C
Density 
1.54 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.386(lit.)
Flash point:
75 °F
storage temp. 
Inert atmosphere,2-8°C
form 
Liquid
pka
-12.08±0.28(Predicted)
color 
Clear colorless
Specific Gravity
1.62
Water Solubility 
Not miscible or difficult to mix in water.
BRN 
1427064
InChIKey
XTGOWLIKIQLYRG-UHFFFAOYSA-N
CAS DataBase Reference
700-16-3(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, pentafluoro-(700-16-3)
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Safety

Hazard Codes 
Xn,F,Xi
Risk Statements 
10-20/21/22-36/37/38
Safety Statements 
26-28-24/25-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
Hazard Note 
Flammable/Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
158798
Product name
Pentafluoropyridine
Purity
≥99%
Packaging
25g
Price
$157
Updated
2024/03/01
TCI Chemical
Product number
P0926
Product name
Pentafluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
P0926
Product name
Pentafluoropyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$210
Updated
2024/03/01
Alfa Aesar
Product number
A19656
Product name
Pentafluoropyridine, 99%
Packaging
5g
Price
$42.65
Updated
2024/03/01
Alfa Aesar
Product number
A19656
Product name
Pentafluoropyridine, 99%
Packaging
25g
Price
$146
Updated
2024/03/01
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Pentafluoropyridine Chemical Properties,Usage,Production

Synthesis

Historically, potassium fluoride has been used with solvents to perform the Halex reaction and Finger and Kruse established the use of polar aprotic solvents in the Halex reaction, with DMSO and DMF being used for the conversion of pentachloropyridine to pentafluoropyridine.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Pentafluoropyridine was used in the preparation of η2-C,C coordinated pentafluoropyridine complex. It was also used in the preparation of polyfluorinated coupling products via Pd(0)-catalyzed cross-coupling reaction with diarylzinc compounds. It was also used as derivatizing reagent in the sensitive GC-MS method for determination of the four endocrine disrupting chemicals.

General Description

The reactions of pentafluoropyridine with cobalt(0) complex, Co(PMe3)4 was investigated.

Purification Methods

Distil it through a concentric tube column; it has in cyclohexane at 256.8nm. [Chambers et al. J Chem Soc 3573 1964, NMR: Bell et al. J Fluorine Chem 1 51 1971.] The hexafluoroantimonate has m 98-102o(dec) after crystallisation from liquid SO2. [Beilstein 20/5 V 401.]

Pentafluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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Pentafluoropyridine Suppliers

Nanjing Lynsci Chemical Co., Ltd
Tel
025-83208253 13851694729
Fax
0086-25-83208253
Email
layefe@163.com
Country
China
ProdList
230
Advantage
62
SHANG FLUORO
Tel
021-021-65170832 15601903708
Email
qinba_1@163.com
Country
China
ProdList
306
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2882
Advantage
65
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View Lastest Price from Pentafluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pentafluoropyridine 700-16-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Hebei Duling International Trade Co. LTD
Product
Pentafluoropyridine 700-16-3
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2022-10-09
Hebei Yanxi Chemical Co., Ltd.
Product
Pentafluoropyridine 700-16-3
Price
US $20.00-8.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07

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