K-252B

Product Name: K-252B
CAS No.: 99570-78-2
Chemical Name: K-252B
Synonyms: K-252B;KT 5556;k-252b solution;K252B READY MADE;Antibiotic K 252b;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;PROTEIN KINASE INHIBITOR K-252B;K252b Antibiotic K 252b KT 5556;(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
CBNumber: CB3452783
Molecular Formula: C26H19N3O5
Formula Weight: 453.45
MOL File: 99570-78-2.mol

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K-252B Property

Boiling point:: 769.8±60.0 °C(Predicted)
Density: 1.78±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml).
form: ready-to-use solution
pka: 3.33±0.40(Predicted)
color: White or off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
RIDADR: UN 1993 / PGIII
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11339
Product name: K252b
Purity: ≥98%
Packaging: 500μg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 11339
Product name: K252b
Purity: ≥98%
Packaging: 1mg
Price: $335
Updated: 2024/03/01

TRC

Product number: K000505
Product name: K252b
Packaging: 2.5mg
Price: $2180
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 65721
Product name: K252b
Packaging: 2.5mg
Price: $3200
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb545968
Product name: K252b
Purity: >98%
Packaging: 1mg
Price: $554.2
Updated: 2021/12/16

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K-252B Chemical Properties,Usage,Production

Description

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC₅₀ = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.

Chemical Properties

Yellow solid

Uses

K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.

Uses

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

References

1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Makino et al. (2012), Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling; PLoS One, 7 e41049

K-252B Preparation Products And Raw materials

Raw materials

Preparation Products

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K-252B Suppliers

China 69 Germany 6 Japan 3 Switzerland 2 United Kingdom 6 United States 18 Global 104

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99570-78-2, K-252BRelated Search:

AKOS 213-252 Amberlite 252, Ion Exchange Resin HC-252 9-CARBAZOLEPROPIONIC ACID KT5720 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 9-ISOPROPYLCARBAZOLE 1,3,5,7,9-Pentaoxa-252, 452,652,852-tetraplumbacyclotridec-11 -ene-10,13-dione, (Z)- POTASSIUM NITRATE EXTRA PURE, B. P.,FCC, E 252 C.I. Acid Red 252 NSC 252 PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.) K-252C K-252B CARBAZOL-9-YL-METHANOL 11,12-Dihydroindolo[2,3-a]carbazole Hydrochlorofluorocarbon-252 (HCFC-252) GP120 (252-272) (1)

PROTEIN KINASE INHIBITOR K-252B

K-252B

K-252B, NOCARDIOPSIS SP

K-252B, NOCARDIOPSIS SPECIES

K252B READY MADE

k-252b solution

Antibiotic K 252b

KT 5556

K252b Antibiotic K 252b KT 5556

(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-

(5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid

99570-78-2

BioChemical

Antibiotics G-M

Antibiotics A to Z

Antibiotics

antibiotic

Antibiotics G-MSerine/Threonine Kinase Biology

Antibiotics

Antibiotics A to

Protein Kinase C (PKC)

Serine/Threonine Kinase Inhibitors

Protein Kinase