ChemicalBook > CAS DataBase List > 2-Fluoro-4-cyanobenzyl bromide

2-Fluoro-4-cyanobenzyl bromide

Product Name
2-Fluoro-4-cyanobenzyl bromide
CAS No.
105942-09-4
Chemical Name
2-Fluoro-4-cyanobenzyl bromide
Synonyms
4-Cyano-2-fluorbenzylbromid;4-(BroMoMethyl)-3-fluoroben;4-CYANO-2-FLUOROBENZYL BROMIDE;2-FLUORO-4-CYANO-BENZYLBROMIDE;4-Cyano-2-fluorobenzylbromide97%;4-(BROMOMETHYL)-3-FLUOROBENZONITRILE;BENZONITRILE, 4-(BROMOMETHYL)-3-FLUORO-;4-(Bromomethyl)-3-fluorobenzonitrile 97%;4-(Bromomethyl)-3-fluorobenzonitrile >4-BroMoMethyl-3-fluorobenzonitrile[4-cyano-2-fluorobenzyl broMide]
CBNumber
CB3471393
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
105942-09-4.mol
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2-Fluoro-4-cyanobenzyl bromide Property

Melting point:
77 °C
Boiling point:
276.4±30.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
Solid
color 
Off-white
Sensitive 
Lachrymatory
InChI
InChI=1S/C8H5BrFN/c9-4-7-2-1-6(5-11)3-8(7)10/h1-3H,4H2
InChIKey
ZESZAIOGACKOMB-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(CBr)C(F)=C1
CAS DataBase Reference
105942-09-4(CAS DataBase Reference)
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Safety

Hazard Codes 
C
RIDADR 
3439
Hazard Note 
Corrosive/Lachrymatory
HazardClass 
8
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3204
Product name
4-(Bromomethyl)-3-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
B3204
Product name
4-(Bromomethyl)-3-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$93
Updated
2025/07/31
TCI Chemical
Product number
B3204
Product name
4-(Bromomethyl)-3-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$280
Updated
2025/07/31
TRC
Product number
C987958
Product name
4-Cyano-2-fluorobenzylbromide
Packaging
250mg
Price
$55
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK584614
Product name
4-Cyano-2-fluorobenzylbromide
Purity
98%
Packaging
1g
Price
$76
Updated
2021/12/16
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2-Fluoro-4-cyanobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

White to yellow fine crystalline powder

Uses

2-Fluoro-4-cyanobenzyl bromide can be used in organic synthesis.

Synthesis

170572-49-3

105942-09-4

General procedure for the synthesis of 4-cyano-2-fluorobenzyl bromide from 3-fluoro-4-methylbenzonitrile: 3-fluoro-4-methylbenzonitrile (40 g, 296 mmol), N-bromosuccinimide (NBS, 63.2 g, 356 mmol), and benzoyl peroxide (3.6 g, 14.8 mmol) were dissolved in carbon tetrachloride (490 mL), and the reaction was performed at reflux for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated and purified by fast column chromatography (eluent: 0-5% ethyl acetate/hexane) to afford the target product 4-(bromomethyl)-3-fluorobenzonitrile (35.4 g, 56% yield).

References

[1] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 12, p. 1647 - 1650
[2] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[3] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 12, p. 1203 - 1207
[4] Patent: WO2016/109361, 2016, A2. Location in patent: Paragraph 00144
[5] Patent: US2010/240719, 2010, A1. Location in patent: Page/Page column 11

2-Fluoro-4-cyanobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-cyanobenzyl bromide Suppliers

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View Lastest Price from 2-Fluoro-4-cyanobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-12
Henan Aochuang Chemical Co.,Ltd.
Product
2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-18
Career Henan Chemical Co
Product
2-Fluoro-4-cyanobenzyl bromide 105942-09-4
Price
US $3.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
100kg
Release date
2019-07-04

105942-09-4, 2-Fluoro-4-cyanobenzyl bromideRelated Search:

alpha-Chloro-o-fluorotoluene Ethidium bromide BENDROFLUMETHIAZIDE Vecuronium bromide Ethyl bromodifluoroacetate Allyl bromide Rocuronium bromide Sodium bromate Dimidium bromide Bromofluoromethane Benzyl bromide Fluorine 3-CYANO-4-FLUOROBENZYL BROMIDE 4-Cyanobenzyl bromide 2-FLUORO-4-METHYLBENZYL BROMIDE Methyl bromide 2-Fluorobenzyl bromide 4-Nitrobenzyl bromide

  • 2-FLUORO-4-CYANO-BENZYLBROMIDE
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  • 4-(BROMOMETHYL)-3-FLUOROBENZONITRILE
  • 4-(BroMoMethyl)-3-fluoroben
  • 4-BroMoMethyl-3-fluorobenzonitrile[4-cyano-2-fluorobenzyl broMide]
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  • 105942-09-4
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  • Fluorine series