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Xylazine Hydrochloride

Product Name
Xylazine Hydrochloride
CAS No.
23076-35-9
Chemical Name
Xylazine Hydrochloride
Synonyms
XYLAZINE HCL;XYLAZIN HYDROCHLORIDE;2-(2,6-DIMETHYLPHENYLAMINO)-5,6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE;N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazine-2-aminehydrochloride;rompun;celactal;Rompun[R];245-417-0;bay-va1470;xylazinechloride
CBNumber
CB3477355
Molecular Formula
C12H17ClN2S
Formula Weight
256.79
MOL File
23076-35-9.mol
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Xylazine Hydrochloride Property

Melting point:
150-164?C (dec.)
storage temp. 
2-8°C
solubility 
≥12.84 mg/mL in DMSO; ≥24.1 mg/mL in EtOH; ≥24.15 mg/mL in H2O
color 
White to Almost white
Water Solubility 
Soluble in water
Merck 
14,10080
BRN 
6448471
InChI
InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
InChIKey
QYEFBJRXKKSABU-UHFFFAOYSA-N
SMILES
N(C1SCCCN=1)C1C(=CC=CC=1C)C.Cl
CAS DataBase Reference
23076-35-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
2811
WGK Germany 
-
RTECS 
XJ0776350
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29349990
Toxicity
dog,LD50,intramuscular,47mg/kg (47mg/kg),Clinical Toxicology. Vol. 15, Pg. 281, 1979.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3264
Product name
Xylazine Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
46995
Product name
Xylazine hydrochloride
Purity
VETRANAL , analytical standard
Packaging
100mg
Price
$60.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1720429
Product name
Xylazine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
X0059
Product name
Xylazine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$100
Updated
2024/03/01
TCI Chemical
Product number
X0059
Product name
Xylazine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$302
Updated
2024/03/01
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Xylazine Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Xylazine Hydrochloride is an alpha-2 agonist with sedative, analgesic, and muscle relaxant properties. It is approved for use in dogs,cats,horses,deer,and elk. This agent causes vomiting in a large percentage of cats and in some dogs. Xylazine is antagonized by yohimbine. It produces effective analgesia in horses and is often used for treating the pain associated with colic and for sedation for minor procedures.It is also used in combination with ketamine for short-term feld procedures in horses,such as castration and suturing of extensive wounds，because this combination usually produces 15 to 20 minutes of recumbency. Extralabel use of xylazine for cesarean sections in cattle and other surgical procedures is common. Xylazine Hydrochloride is used in cats and dogs as a tranquilizer and in combination with other injectable agents for surgical procedures.

Definition

ChEBI: Xylazine hydrochloride is the hydrochloride salt of xylazine. It is used as a sedative, analgesic, and muscle relaxant in veterinary medicine. It has a role as an alpha-adrenergic agonist, an analgesic, an emetic, a muscle relaxant and a sedative. It contains a xylazine(1+).

brand name

Rompun (Bayer Animal Health).

Biological Activity

Xylazine Hydrochloride is a strong agonist of α2-adrenoceptor [1].xylazine hcl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mm) [2]. in the analgesic testing, xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. in addition, xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the ic50 value of 18nm. furthermore, xylazine has displayed a potent specific [3h]-dihydromorphine binding inhibition with the ic50 value of 8μm in opiate receptor binding test [1].

Biochem/physiol Actions

Xylazine is used as a sedative in goats as it is safe, active and a cheap drug. It is a centrally acting drug, which exhibits muscle relaxant and analgesic properties.

Side effects

Respiratory depression, low blood pressure, slowed heart rate, hypothermia, pupil constriction and, sometimes, high blood sugar levels.
The pupil constriction and respiratory depression are particularly of concern, as these are very common and widely understood effects of an opioid overdose.
Severe, necrotic skin ulcerations are the most striking side effect of xylazine. Notably, while these skin ulcerations may appear at the site of injection, they may appear at a completely different site on the body altogether. Soft tissue infections are often associated with IV drug use of more conventional illicit substances such as opioids, but these are almost always located at the injection site.

Veterinary Drugs and Treatments

Xylazine Hydrochloride is approved for use in dogs, cats, horses, deer, and elk. It is indicated in dogs, cats, and horses to produce a state of sedation with a shorter period of analgesia, and as a preanesthetic before local or general anesthesia. Because of the emetic action of xylazine in cats, it is occasionally used to induce vomiting after ingesting toxins.

References

[1] s. browning, d.lawrence1, a.livingston & b.morris. interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] colić m1, cupić v, pavicić l, vucević d, varagić vm. xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. methods find exp clin pharmacol. 2000 sep;22(7):557-62.

Xylazine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Xylazine Hydrochloride Suppliers

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View Lastest Price from Xylazine Hydrochloride manufacturers

Shanghai Longyu Biotechnology Co., Ltd.
Product
xylazine hydrochloride 23076-35-9
Price
US $1.00/g
Min. Order
1g
Purity
99
Supply Ability
20tons
Release date
2022-01-19
ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
Product
Xylazine hydrochloride 23076-35-9
Price
US $1.00/g
Min. Order
10g
Purity
99
Supply Ability
5ton/month
Release date
2022-05-27
Shandong Hanjiang Chemical Co., Ltd
Product
Xylazine hydrochloride 23076-35-9
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-11

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  • 2-[2,6-DIMETHYLPHENYLAMINO]-4H-5,6-DIHYDROTHIAZINE HYDROCHLORIDE
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  • N-(2,6-DiMethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-aMine · HCl, (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-diMethyl-phenyl)-aMine · HCl
  • N-(2,6-diMethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-aMine hydrochloride
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