ChemicalBook > CAS DataBase List > 6-AZATHYMINE

6-AZATHYMINE

Product Name: 6-AZATHYMINE
CAS No.: 932-53-6
Chemical Name: 6-AZATHYMINE
Synonyms: NSC3426;ai3-50849;usafcb-28;USAF cb-28;6-AZATHYMINE;6-Azathymine,98%;WLN: T6NMVMVJ F1;6-Azathymine >6-AZA-5-METHYLURACIL;5-Methyl-6-azauracil
CBNumber: CB3486083
Molecular Formula: C4H5N3O2
Formula Weight: 127.1
MOL File: 932-53-6.mol

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6-AZATHYMINE Property

Melting point:: 210-212°C
Boiling point:: 235.85°C (rough estimate)
Density: 1.4748 (rough estimate)
refractive index: 1.5000 (estimate)
pka: 7.6(at 25℃)
form: powder to crystal
color: White to Almost white
Merck: 14,903
BRN: 126863
InChI: InChI=1S/C4H5N3O2/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9)
InChIKey: XZWMZFQOHTWGQE-UHFFFAOYSA-N
SMILES: N1=C(C)C(=O)NC(=O)N1
CAS DataBase Reference: 932-53-6(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
RTECS: XY8050000
HS Code: 2934.10.9000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A0556
Product name: 6-Azathymine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $70
Updated: 2023/06/20

Usbiological

Product number: 295345
Product name: 6-Azathymine
Packaging: 2g
Price: $339
Updated: 2021/12/16

TRC

Product number: B486370
Product name: 6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione
Packaging: 10mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-0131257
Product name: 6-Azathymine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA30768
Product name: 6-Azathymine
Packaging: 2g
Price: $80
Updated: 2021/12/16

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6-AZATHYMINE Chemical Properties,Usage,Production

Uses

6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].

Definition

ChEBI: A nucleobase analogue that is thymine in which the CH group at position 6 is replaced by nitrogen.

in vivo

The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-¹⁴C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives^[3].

References

[1] N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. DOI:10.1111/j.1432-1033.1990.tb15457.x
[2] W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. DOI:10.1016/0006-3002(56)90279-7
[3] R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. DOI:10.1016/0006-2952(62)90055-2
[4] B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220.

6-AZATHYMINE Preparation Products And Raw materials

Raw materials

Sodium acetate Sodium Pyruvic acid Ethylene glycol Semicarbazide hydrochloride

Preparation Products

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6-AZATHYMINE Suppliers

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932-53-6, 6-AZATHYMINERelated Search:

6-AZATHYMINE 2-Thio-6-azathymine, 3,4-Dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one,2-THIO-6-AZATHYMINE 6-Azauracil METRIBUZIN-DIKETO METRIBUZIN-DESAMINO-DIKETO 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE 3-(3,5-DIOXO-2,3,4,5-TETRAHYDRO-[1,2,4]TRIAZIN-6-YL)-PROPIONIC ACID 2-(3,5-DIMETHYLPHENYL)-4-METHYL-6-[1-(4-METHYLPHENYL)-1H-PYRAZOL-4-YL]-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 2-(3,5-DIMETHYLPHENYL)-4-METHYL-6-(3-[4-(TRIFLUOROMETHOXY)ANILINO]ACRYLOYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14298 AURORA 14829 AURORA 14212 6-ACETYL-2-(2,4-DIFLUOROPHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14826 SALOR-INT L136379-1EA 2-(4-FLUOROPHENYL)-3,5-DIOXO-4-[4-(TRIFLUOROMETHYL)BENZYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE 6-ACETYL-2-(4-CHLOROPHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14299

1,2,4-TRIAZINE-3,5(2H,4H)-DIONE, 6-METHYL-

6-AZA-5-METHYLURACIL

6-AZA-2,4-DIHYDROXY-5-METHYL-PYRIMIDINE

6-AZATHYMINE

6-METHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE

3,5-DIHYDROXY-6-METHYL-1,2,4-TRIAZINE

6-Azathymine,98%

6-METHYL-S-TRIAZINE-3,5-DIONE

6-AZATHYMIN extrapure

6-methyl-2H-1,2,4-triazine-3,5-dione

6-methyl-2H-1,2,4-triazine-3,5-quinone

6-Methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

1,2,4-Triazine-3,5(2H,4H)-dione, 6-methyl- (9CI)

NSC3426

WLN: T6NMVMVJ F1

6-Methyl-as-triazine-3,5-d

4h)-dione,6-methyl-as-triazine-5(2h

4-triazine-3,5(2h,4h)-dione,6-methyl-2

5-Methyl-6-azauracil

6-Methyl-1,2,4-triazine-3,5-dione

6-methyl-as-triazine-3,5-(2h,4h)-dione

6-Methyl-as-triazine-3,5(2H,4H)-dione

6-methyl-as-triazine-3,5-diol

ai3-50849

as-Triazine-3,5(2H,4H)-dione, 6-methyl-

As-triazine-3,5-diol, 6-methyl-

USAF cb-28

usafcb-28

6-Azathymine &gt

6-AZATHYMINE USP/EP/BP

6-Azathymine extrapure, 98%

6-Azathymine,6AZATHYMINE,antibacterial,nucleobase,Inhibitor,Influenza Virus,DNA,6-nitrogen,inhibit,thymine,antiviral,DNA/RNA Synthesis,6 AZATHYMINE,Bacterial,Nucleoside Antimetabolite/Analog,aminotransferase

932-53-6

Vitamins and Derivatives

Nucleic acids