6-Azauracil
- Product Name
- 6-Azauracil
- CAS No.
- 461-89-2
- Chemical Name
- 6-Azauracil
- Synonyms
- 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE;1,2,4-triazine-3,5-diol;Azauracil;AZU;6-AU;ipo3834;nsc3425;NSC 3425;IPO 3834;USAF cb-30
- CBNumber
- CB9223189
- Molecular Formula
- C3H3N3O2
- Formula Weight
- 113.07
- MOL File
- 461-89-2.mol
6-Azauracil Property
- Melting point:
- 274-275 °C(lit.)
- Boiling point:
- 211.75°C (rough estimate)
- Density
- 1.5988 (rough estimate)
- refractive index
- 1.4264 (estimate)
- storage temp.
- Store below +30°C.
- form
- Fine Crystalline Powder
- pka
- 7.78±0.20(Predicted)
- color
- White to light yellow
- Water Solubility
- Partly soluble in water, ethanol, DMSO, and 1 M NH4OH (50 mg/ml).
- BRN
- 116472
- InChI
- InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
- InChIKey
- SSPYSWLZOPCOLO-UHFFFAOYSA-N
- SMILES
- N1=CC(=O)NC(=O)N1
- CAS DataBase Reference
- 461-89-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,2,4-Triazine-3,5(2H,4H)-dione(461-89-2)
- EPA Substance Registry System
- 1,2,4-Triazine-3,5(2H,4H)-dione (461-89-2)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-63-25
- Safety Statements
- 26-36-45-38-36/37/39
- WGK Germany
- 3
- RTECS
- XY7700000
- F
- 10-23
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29336980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 8.41156
- Product name
- 6-Azauracil
- Purity
- for synthesis
- Packaging
- 5G
- Price
- $85.8
- Updated
- 2024/03/01
- Product number
- A1757
- Product name
- 6-Azauracil
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $95.2
- Updated
- 2024/03/01
- Product number
- 8.41156
- Product name
- 6-Azauracil
- Purity
- for synthesis
- Packaging
- 25g
- Price
- $424
- Updated
- 2024/03/01
- Product number
- A0558
- Product name
- 6-Azauracil
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $19
- Updated
- 2024/03/01
- Product number
- A0558
- Product name
- 6-Azauracil
- Purity
- >99.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $53
- Updated
- 2024/03/01
6-Azauracil Chemical Properties,Usage,Production
Chemical Properties
white to light yellow fine crystalline powder
Uses
6-Azauracil (6-AU) is used as a growth inhibitor of various microorganisms via depletion of intracellular GTP and UTP nucleotide pools. 6-Azauracil has been widely used in investigations on modulation of transcription, especially in yeast models.
Definition
ChEBI: 6-azauracil is a 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions. It has a role as an antimetabolite. It is a member of 1,2,4-triazines and a nucleobase analogue.
Synthesis Reference(s)
The Journal of Organic Chemistry, 23, p. 1522, 1958 DOI: 10.1021/jo01104a033
Biochem/physiol Actions
6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP)?and uridine?triphosphate (UTP) nucleotide pools.
Safety Profile
Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Mode of action
6-Azauracil is a growth inhibitor effective on a variety of microorganisms. It functions by depleting the intracellular GTP and UTP nucleotide supply. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways, exaggerate the growth defect of cells in the presence of 6 AU.
6-Azauracil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Azauracil manufacturers
- Product
- 6-Azauracil 461-89-2
- Price
- US $0.00/kg
- Min. Order
- 10kg
- Purity
- 98%
- Supply Ability
- kg grade
- Release date
- 2023-05-10
- Product
- 6-Azauracil 461-89-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2023-03-23
- Product
- 6-Azauracil 461-89-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14