ChemicalBook > CAS DataBase List > 6-Azauracil

6-Azauracil

Product Name
6-Azauracil
CAS No.
461-89-2
Chemical Name
6-Azauracil
Synonyms
1,2,4-TRIAZINE-3,5(2H,4H)-DIONE;1,2,4-triazine-3,5-diol;Azauracil;AZU;6-AU;ipo3834;nsc3425;NSC 3425;IPO 3834;USAF cb-30
CBNumber
CB9223189
Molecular Formula
C3H3N3O2
Formula Weight
113.07
MOL File
461-89-2.mol
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6-Azauracil Property

Melting point:
274-275 °C(lit.)
Boiling point:
211.75°C (rough estimate)
Density 
1.5988 (rough estimate)
refractive index 
1.4264 (estimate)
storage temp. 
Store below +30°C.
form 
Fine Crystalline Powder
pka
7.78±0.20(Predicted)
color 
White to light yellow
Water Solubility 
Partly soluble in water, ethanol, DMSO, and 1 M NH4OH (50 mg/ml).
BRN 
116472
InChI
InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChIKey
SSPYSWLZOPCOLO-UHFFFAOYSA-N
SMILES
N1=CC(=O)NC(=O)N1
CAS DataBase Reference
461-89-2(CAS DataBase Reference)
NIST Chemistry Reference
1,2,4-Triazine-3,5(2H,4H)-dione(461-89-2)
EPA Substance Registry System
1,2,4-Triazine-3,5(2H,4H)-dione (461-89-2)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-63-25
Safety Statements 
26-36-45-38-36/37/39
WGK Germany 
3
RTECS 
XY7700000
10-23
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29336980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41156
Product name
6-Azauracil
Purity
for synthesis
Packaging
5G
Price
$85.8
Updated
2024/03/01
Sigma-Aldrich
Product number
A1757
Product name
6-Azauracil
Purity
≥98%
Packaging
5g
Price
$95.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41156
Product name
6-Azauracil
Purity
for synthesis
Packaging
25g
Price
$424
Updated
2024/03/01
TCI Chemical
Product number
A0558
Product name
6-Azauracil
Purity
>99.0%(HPLC)(T)
Packaging
1g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
A0558
Product name
6-Azauracil
Purity
>99.0%(HPLC)(T)
Packaging
5g
Price
$53
Updated
2024/03/01
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6-Azauracil Chemical Properties,Usage,Production

Chemical Properties

white to light yellow fine crystalline powder

Uses

6-Azauracil (6-AU) is used as a growth inhibitor of various microorganisms via depletion of intracellular GTP and UTP nucleotide pools. 6-Azauracil has been widely used in investigations on modulation of transcription, especially in yeast models.

Definition

ChEBI: 6-azauracil is a 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions. It has a role as an antimetabolite. It is a member of 1,2,4-triazines and a nucleobase analogue.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1522, 1958 DOI: 10.1021/jo01104a033

Biochem/physiol Actions

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP)?and uridine?triphosphate (UTP) nucleotide pools.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Mode of action

6-Azauracil is a growth inhibitor effective on a variety of microorganisms. It functions by depleting the intracellular GTP and UTP nucleotide supply. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways, exaggerate the growth defect of cells in the presence of 6 AU.

6-Azauracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Azauracil Suppliers

ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
Fax
+86-512-69200360
Email
sales@iticmedchem.com
Country
China
ProdList
430
Advantage
61
Hebei Fanbo Pharmaceutical Technology Co., Ltd.
Tel
0531-88163906 15588346797
Email
fanbomedical@163.com
Country
China
ProdList
242
Advantage
58
Chongqing Longsheng Pharmaceutical Co., Ltd
Tel
17791355738
Email
sales@cqlonghoo.com
Country
China
ProdList
82
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from 6-Azauracil manufacturers

Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
6-Azauracil 461-89-2
Price
US $0.00/kg
Min. Order
10kg
Purity
98%
Supply Ability
kg grade
Release date
2023-05-10
Unipharm pharmaceutical industry Co., Ltd
Product
6-Azauracil 461-89-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2023-03-23
Shaanxi Dideu Medichem Co. Ltd
Product
6-Azauracil 461-89-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14

461-89-2, 6-AzauracilRelated Search:


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  • BioChemical
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  • Nucleoside Analogs
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