6-Azauracil

Product Name: 6-Azauracil
CAS No.: 461-89-2
Chemical Name: 6-Azauracil
Synonyms: 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE;1,2,4-triazine-3,5-diol;Azauracil;AZU;6-AU;ipo3834;nsc3425;NSC 3425;IPO 3834;USAF cb-30
CBNumber: CB9223189
Molecular Formula: C3H3N3O2
Formula Weight: 113.07
MOL File: 461-89-2.mol

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6-Azauracil Property

Melting point:: 274-275 °C(lit.)
Boiling point:: 211.75°C (rough estimate)
Density: 1.5988 (rough estimate)
refractive index: 1.4264 (estimate)
storage temp.: Store below +30°C.
form: Fine Crystalline Powder
pka: 7.78±0.20(Predicted)
color: White to light yellow
Water Solubility: Partly soluble in water, ethanol, DMSO, and 1 M NH4OH (50 mg/ml).
BRN: 116472
InChI: InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
InChIKey: SSPYSWLZOPCOLO-UHFFFAOYSA-N
SMILES: N1=CC(=O)NC(=O)N1
CAS DataBase Reference: 461-89-2(CAS DataBase Reference)
NIST Chemistry Reference: 1,2,4-Triazine-3,5(2H,4H)-dione(461-89-2)
EPA Substance Registry System: 1,2,4-Triazine-3,5(2H,4H)-dione (461-89-2)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-63-25
Safety Statements: 26-36-45-38-36/37/39
WGK Germany: 3
RTECS: XY7700000
F: 10-23
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29336980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.41156
Product name: 6-Azauracil
Purity: for synthesis
Packaging: 5G
Price: $85.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: A1757
Product name: 6-Azauracil
Purity: ≥98%
Packaging: 5g
Price: $95.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41156
Product name: 6-Azauracil
Purity: for synthesis
Packaging: 25g
Price: $424
Updated: 2024/03/01

TCI Chemical

Product number: A0558
Product name: 6-Azauracil
Purity: >99.0%(HPLC)(T)
Packaging: 1g
Price: $19
Updated: 2024/03/01

TCI Chemical

Product number: A0558
Product name: 6-Azauracil
Purity: >99.0%(HPLC)(T)
Packaging: 5g
Price: $53
Updated: 2024/03/01

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6-Azauracil Chemical Properties,Usage,Production

Chemical Properties

white to light yellow fine crystalline powder

Uses

6-Azauracil (6-AU) is used as a growth inhibitor of various microorganisms via depletion of intracellular GTP and UTP nucleotide pools. 6-Azauracil has been widely used in investigations on modulation of transcription, especially in yeast models.

Definition

ChEBI: 6-azauracil is a 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions. It has a role as an antimetabolite. It is a member of 1,2,4-triazines and a nucleobase analogue.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1522, 1958 DOI: 10.1021/jo01104a033

Biochem/physiol Actions

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP)?and uridine?triphosphate (UTP) nucleotide pools.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Mode of action

6-Azauracil is a growth inhibitor effective on a variety of microorganisms. It functions by depleting the intracellular GTP and UTP nucleotide supply. Mutations in transcriptional elongation machinery, as well as mutations in a variety of other pathways, exaggerate the growth defect of cells in the presence of 6 AU.

6-Azauracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Azauracil Suppliers

Americas 1 Belgium 3 China 195 Europe 3 France 2 Germany 10 India 4 Japan 4 South Korea 1 Sweden 1 Switzerland 4 The Netherlands 1 United Kingdom 14 United States 44 Global 287

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Shigematsu & Co., Ltd

Tel: --
Fax: --
Email: info@shigematsu-bio.com
Country: Japan
ProdList: 1066
Advantage: 64

Wako Pure Chemical Industries, Ltd.

Tel: --
Fax: --
Email: labchem-tec@wako-chem.co.jp
Country: Japan
ProdList: 6819
Advantage: 80

Nacalai Tesque, Inc.

Tel: --
Fax: --
Email: info-tech@nacalai.co.jp
Country: Japan
ProdList: 6046
Advantage: 75

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View Lastest Price from 6-Azauracil manufacturers

Suzhou Ryan Pharmachem Technology Co.,Ltd.

Product: 6-Azauracil 461-89-2
Price: US $0.00/kg
Min. Order: 10kg
Purity: 98%
Supply Ability: kg grade
Release date: 2023-05-10

Unipharm pharmaceutical industry Co., Ltd

Product: 6-Azauracil 461-89-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2023-03-23

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Azauracil 461-89-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

461-89-2, 6-AzauracilRelated Search:

Sulfadiazine 1,3,5-Triazine Hexazinone Solvent Red 43 Metribuzin Buprofezin 5-BROMO-6-AZAURACIL ,97%,5-BROMO-6-AZAURACIL 6-AZAURACIL RIBOSIDE,6-azauracil-beta-d-ribosid 5-Methyl-6-azauracil AZAURACIL, 5-(RG) 5-METHYLMERCAPTO-6-AZAURACIL,5-(METHYLTHIO)-6-AZAURACIL AZAURACIL, 6- 5-MERCAPTO-6-AZAURACIL SODIUM SALT 5-HYDRAZINO-6-AZAURACIL 5-AZAURACIL, MONOHYDRATE 5-N-MORPHOLINO-6-AZAURACIL AZAURACIL, 5-,5-AZAURACIL 6-Azauracil

4(6)-Azauracil

As-Triazine-3,5(2H,4H)-dione

As-Triazine-3,5-diol

Azauracil

AZU

IPO 3834

ipo3834

NSC 3425

nsc3425

s-Triazine-3,5(2H,4H)-dione

USAF cb-30

TIMTEC-BB SBB004317

AZAURACIL, 6-

6-AZA-2,4-DIHYDROXYPYRIMIDINE

6-AZAURACIL

3,5-DIHYDROXY-1,2,4-TRIAZINE

1,2,4-triazine-3,5-diol

2H,4H-AS-TRIAZINE-3,5-DIONE

1,2,4-TRIAZINE-3,5-DIONE

1,2,4-TRIAZINE-3,5(2H,4H)-DIONE

6-AZAURACIL CRYSTALLINE

6-AZAURACIL 99%

6-Azauracil,98%

6-AZAURAZIL

6-azauridine 6-Azauracil

AZAURACIL, 6-(RG)

S-TRIAZINE-3,5-DIONE

3,5-DIOXO-[1,2,4]TRIAZINE

1,2,4-Triazine-3,5(2H,4H)

1,2,4-Triazine-3,5(2H,4H)-dione, 3,5-Dihydroxy-1,2,4-triazine, 6-Aza-2,4-dihydroxypyrimidine

2,3,4,5-Tetrahydro-1,2,4-triazine-3,5-dione

6-Azauracil,99%

2H-1,2,4-triazine-3,5-dione

2H-1,2,4-triazine-3,5-quinone

as-Triazine-3,5(2H,4H)-dione (8CI)

WLN: T6NMVMVJ

6 - nitrogen iMpurity uracil

6-AU

6-Azauracil &gt

1,2,4-Triazine-3,5(2H,4H)-dione (9CI, ACI)

461-89-2

BioChemical

Biochemicals and Reagents

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Nucleic acids

Pyridines, Pyrimidines, Purines and Pteredines