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6-AZATHYMINE

Product Name
6-AZATHYMINE
CAS No.
932-53-6
Chemical Name
6-AZATHYMINE
Synonyms
NSC3426;ai3-50849;usafcb-28;USAF cb-28;6-AZATHYMINE;6-Azathymine,98%;WLN: T6NMVMVJ F1;6-Azathymine >6-AZA-5-METHYLURACIL;5-Methyl-6-azauracil
CBNumber
CB3486083
Molecular Formula
C4H5N3O2
Formula Weight
127.1
MOL File
932-53-6.mol
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6-AZATHYMINE Property

Melting point:
210-212°C
Boiling point:
235.85°C (rough estimate)
Density 
1.4748 (rough estimate)
refractive index 
1.5000 (estimate)
pka
7.6(at 25℃)
form 
powder to crystal
color 
White to Almost white
Merck 
14,903
BRN 
126863
InChI
InChI=1S/C4H5N3O2/c1-2-3(8)5-4(9)7-6-2/h1H3,(H2,5,7,8,9)
InChIKey
XZWMZFQOHTWGQE-UHFFFAOYSA-N
SMILES
N1=C(C)C(=O)NC(=O)N1
CAS DataBase Reference
932-53-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
RTECS 
XY8050000
HS Code 
2934.10.9000
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A0556
Product name
6-Azathymine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$70
Updated
2023/06/20
Usbiological
Product number
295345
Product name
6-Azathymine
Packaging
2g
Price
$339
Updated
2021/12/16
TRC
Product number
B486370
Product name
6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione
Packaging
10mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-0131257
Product name
6-Azathymine
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA30768
Product name
6-Azathymine
Packaging
2g
Price
$80
Updated
2021/12/16
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6-AZATHYMINE Chemical Properties,Usage,Production

Uses

6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4].

Definition

ChEBI: A nucleobase analogue that is thymine in which the CH group at position 6 is replaced by nitrogen.

in vivo

The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-14C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives[3].

References

[1] N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. DOI:10.1111/j.1432-1033.1990.tb15457.x
[2] W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. DOI:10.1016/0006-3002(56)90279-7
[3] R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. DOI:10.1016/0006-2952(62)90055-2
[4] B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220.

6-AZATHYMINE Preparation Products And Raw materials

Raw materials

Sodium acetate Sodium Pyruvic acid Ethylene glycol Semicarbazide hydrochloride

Preparation Products

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6-AZATHYMINE Suppliers

Americas 1 China 82 Europe 1 Germany 3 India 9 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 5 United States 16 Global 120
TCI Chemicals (India) Pvt. Ltd.
Tel
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Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Triveni chemicals
Tel
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Email
sales@trivenichemical.com
Country
India
ProdList
6088
Advantage
58
Alfa Aesar
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Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Sisco Research Laboratories Pvt. Ltd.
Tel
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Email
marketing@srlchem.com
Country
India
ProdList
4315
Advantage
58
Oxford laboratories
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India
ProdList
652
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58
Sisco Resech Laboratories Private Limited
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India
ProdList
655
Advantage
58
CHEMSWORTH
Tel
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Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30

932-53-6, 6-AZATHYMINERelated Search:

6-AZATHYMINE 2-Thio-6-azathymine, 3,4-Dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one,2-THIO-6-AZATHYMINE 6-Azauracil METRIBUZIN-DIKETO METRIBUZIN-DESAMINO-DIKETO 3,5-DIOXO-2-[3-(TRIFLUOROMETHYL)PHENYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE 3-(3,5-DIOXO-2,3,4,5-TETRAHYDRO-[1,2,4]TRIAZIN-6-YL)-PROPIONIC ACID 2-(3,5-DIMETHYLPHENYL)-4-METHYL-6-[1-(4-METHYLPHENYL)-1H-PYRAZOL-4-YL]-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 2-(3,5-DIMETHYLPHENYL)-4-METHYL-6-(3-[4-(TRIFLUOROMETHOXY)ANILINO]ACRYLOYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14298 AURORA 14829 AURORA 14212 6-ACETYL-2-(2,4-DIFLUOROPHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14826 SALOR-INT L136379-1EA 2-(4-FLUOROPHENYL)-3,5-DIOXO-4-[4-(TRIFLUOROMETHYL)BENZYL]-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE 6-ACETYL-2-(4-CHLOROPHENYL)-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE AURORA 14299

  • 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE, 6-METHYL-
  • 6-AZA-5-METHYLURACIL
  • 6-AZA-2,4-DIHYDROXY-5-METHYL-PYRIMIDINE
  • 6-AZATHYMINE
  • 6-METHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
  • 3,5-DIHYDROXY-6-METHYL-1,2,4-TRIAZINE
  • 6-Azathymine,98%
  • 6-METHYL-S-TRIAZINE-3,5-DIONE
  • 6-AZATHYMIN extrapure
  • 6-methyl-2H-1,2,4-triazine-3,5-dione
  • 6-methyl-2H-1,2,4-triazine-3,5-quinone
  • 6-Methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione
  • 1,2,4-Triazine-3,5(2H,4H)-dione, 6-methyl- (9CI)
  • NSC3426
  • WLN: T6NMVMVJ F1
  • 6-Methyl-as-triazine-3,5-d
  • 4h)-dione,6-methyl-as-triazine-5(2h
  • 4-triazine-3,5(2h,4h)-dione,6-methyl-2
  • 5-Methyl-6-azauracil
  • 6-Methyl-1,2,4-triazine-3,5-dione
  • 6-methyl-as-triazine-3,5-(2h,4h)-dione
  • 6-Methyl-as-triazine-3,5(2H,4H)-dione
  • 6-methyl-as-triazine-3,5-diol
  • ai3-50849
  • as-Triazine-3,5(2H,4H)-dione, 6-methyl-
  • As-triazine-3,5-diol, 6-methyl-
  • USAF cb-28
  • usafcb-28
  • 6-Azathymine &gt
  • 6-AZATHYMINE USP/EP/BP
  • 6-Azathymine extrapure, 98%
  • 6-Azathymine,6AZATHYMINE,antibacterial,nucleobase,Inhibitor,Influenza Virus,DNA,6-nitrogen,inhibit,thymine,antiviral,DNA/RNA Synthesis,6 AZATHYMINE,Bacterial,Nucleoside Antimetabolite/Analog,aminotransferase
  • 932-53-6
  • Vitamins and Derivatives
  • Nucleic acids