(2-CHLORO-PYRIDIN-4-YL)-METHANOL
- Product Name
- (2-CHLORO-PYRIDIN-4-YL)-METHANOL
- CAS No.
- 100704-10-7
- Chemical Name
- (2-CHLORO-PYRIDIN-4-YL)-METHANOL
- Synonyms
- oro-4-pyridinyL;BUTTPARK 154\50-15;2-Chloro-4-pyridinemethanol;(2-chloro-4-pyridyl)methanol;4-Pyridinemethanol, 2-chloro-;(2-CHLORO-4-PYRIDINYL)METHANOL;2-Chloropyridine-4-methanol,97%;2-Chloro-4-pyridinemethanol >(2-CHLORO-PYRIDIN-4-YL)-METHANOL;2-CHLORO-4-HYDROXYMETHYLPYRIDINE
- CBNumber
- CB3487787
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 100704-10-7.mol
(2-CHLORO-PYRIDIN-4-YL)-METHANOL Property
- Melting point:
- 65.5 °C
- Boiling point:
- 279.0±25.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 13.08±0.10(Predicted)
- color
- White to Light yellow
- λmax
- 262nm(MeOH)(lit.)
- CAS DataBase Reference
- 100704-10-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-28-45
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 714445
- Product name
- (2-Chloro-4-pyridinyl)methanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40.8
- Updated
- 2023/01/07
- Product number
- C2595
- Product name
- 2-Chloro-4-pyridinemethanol
- Purity
- >96.0%(GC)(T)
- Packaging
- 1g
- Price
- $159
- Updated
- 2024/03/01
- Product number
- C596193
- Product name
- (2-Chloropyridin-4-yl)methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 024833
- Product name
- (2-Chloro-4-pyridinyl)methanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 024833
- Product name
- (2-Chloro-4-pyridinyl)methanol
- Purity
- 97%
- Packaging
- 500mg
- Price
- $12
- Updated
- 2021/12/16
(2-CHLORO-PYRIDIN-4-YL)-METHANOL Chemical Properties,Usage,Production
Uses
(2-chloro-4-pyridinyl)methanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: (2-Chloro-4-pyridinyl)methanol is a member of pyridines and an organohalogen compound.
Synthesis
58481-11-1
100704-10-7
The general procedure for the synthesis of 2-chloro-4-hydroxymethylpyridine from methyl 2-chloropyridine-4-carboxylate was as follows: 2-chloropyridine-4-methanol (reference Compound No. 7-1) was prepared with reference to Example 7. Under nitrogen protection, 0.95 M hexane solution of hydrogenated diisobutylaluminum (200 mL, 190 mmol) was slowly added dropwise to a solution of anhydrous tetrahydrofuran (300 mL) containing methyl 2-chloropyridine-4-carboxylate (11 g, 62 mmol), and the reaction mixture was stirred for 2 hr. under the cooling of an ice bath. Subsequently, 1N hydrochloric acid (200 mL) was added to the reaction system and stirring was continued for 1 hour at room temperature. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution (400 mL) was added to neutralize and then extracted three times with ethyl acetate (100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 8.5 g of white solid 2-chloro-4-hydroxymethylpyridine in 95% yield. The structure of the product was confirmed by 1H-NMR (500 MHz, DMSO-d6): δ 4.56 (d, J = 5.8 Hz, 2H), 5.54 (t, J = 5.8 Hz, 1H), 7.34 (d, J = 4.9 Hz, 1H), 7.41 (s, 1H), 8.34 (d, J = 4.9 Hz, 1H).
References
[1] Patent: EP1602647, 2005, A1. Location in patent: Page/Page column 48
[2] Patent: WO2008/11478, 2008, A2. Location in patent: Page/Page column 76-77
[3] Patent: WO2017/42643, 2017, A1. Location in patent: Page/Page column 25
[4] Patent: WO2006/96338, 2006, A1. Location in patent: Page/Page column 47
[5] Patent: WO2006/2383, 2006, A2. Location in patent: Page/Page column 55
(2-CHLORO-PYRIDIN-4-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(2-CHLORO-PYRIDIN-4-YL)-METHANOL Suppliers
- Tel
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- him@interchim.com
- Country
- France
- ProdList
- 2725
- Advantage
- 58
- Tel
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- fr.fisher@thermofisher.com
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- France
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View Lastest Price from (2-CHLORO-PYRIDIN-4-YL)-METHANOL manufacturers
- Product
- (2-Chloro-4-pyridinyl)Methanol 100704-10-7
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-08-11
- Product
- (2-CHLORO-PYRIDIN-4-YL)-METHANOL 100704-10-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-02
- Product
- (2-CHLORO-PYRIDIN-4-YL)-METHANOL 100704-10-7
- Price
- US $500.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-04