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BMS-908662

Product Name
BMS-908662
CAS No.
870603-16-0
Chemical Name
BMS-908662
Synonyms
BMS-908662;BMS-908662(1X-281);Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
CBNumber
CB34919927
Molecular Formula
C24H19ClN4O4
Formula Weight
462.89
MOL File
870603-16-0.mol
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BMS-908662 Property

Density 
1.526±0.06 g/cm3(Predicted)
pka
10.77±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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BMS-908662 Chemical Properties,Usage,Production

Uses

XL-281 (BMS-908662) is an orally active inhibitor for RAF kinase, with IC50s of 2.6, 4.5 and 6 nM, for CRAF, B-RAF, and B-RAFV600E, respectively. XL-281 exhibits antitumor activity[1].

IC 50

c-Raf: 2.6 nM (IC50); B-Raf: 4.5 nM (IC50); B-RafV600E: 6 nM (IC50)

References

[1] Dickson MA, et al., Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):349-56. DOI:10.1007/s10637-014-0191-5

BMS-908662 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-908662 Suppliers

China 7 United States 2 Global 9
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

870603-16-0, BMS-908662Related Search:

XL 228 XL-019 XL413 (hydrochloride) 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]- XL-388 XL888 XL765 2-methoxyethyl 4-((4-(4-chlorophenoxy)-3,5-difluorophenyl)sulfonyl)-3-(hydroxycarbamoyl)piperazine-1-carboxylate

  • BMS-908662
  • Carbamic acid, N-[6-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester
  • BMS-908662(1X-281)
  • 870603-16-0