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NEMONAPRIDE

Product Name
NEMONAPRIDE
CAS No.
75272-39-8
Chemical Name
NEMONAPRIDE
Synonyms
C12915;Emilace;ym-09151;emonapride;YM 09151-2;NEMONAPRIDE;nobenzamide;inobenzamide;(2R,3R)-nemonapride;cis-(+-)-rrolidinyl)
CBNumber
CB3492220
Molecular Formula
C21H26ClN3O2
Formula Weight
387.9
MOL File
75272-39-8.mol
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NEMONAPRIDE Property

Melting point:
152-153°C
storage temp. 
Store at RT
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
75272-39-8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21376
Product name
Nemonapride
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21376
Product name
Nemonapride
Purity
≥98%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
21376
Product name
Nemonapride
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
21376
Product name
Nemonapride
Purity
≥98%
Packaging
50mg
Price
$844
Updated
2024/03/01
Tocris
Product number
1746
Product name
Nemonapride
Purity
≥99%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
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NEMONAPRIDE Chemical Properties,Usage,Production

Description

Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.

Description

Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).

Chemical Properties

Colourless Crystalline Solid

Originator

Yamanouchi (Japan)

Uses

Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.

Uses

A selective dopamine D2 receptor antagonist. Used as an antipsychotic

Definition

ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.

brand name

Emirace

Biological Activity

Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

storage

Store at RT

NEMONAPRIDE Preparation Products And Raw materials

Raw materials

Ethyl chloroformate Hydroxylamine hydrochloride Nemonapride

Preparation Products

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NEMONAPRIDE Suppliers

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75272-39-8, NEMONAPRIDERelated Search:

(S)-TERT-LEUCINOL 1-BENZYL-3-ACETAMIDOPYRROLIDINE (R)-(-)-1-Benzyl-3-aminopyrrolidine (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE METOCLOPRAMIDE HCL (R)-(+)-BENZYL-3-ACETYLAMINOPYRROLIDINE& NEMONAPRIDE (3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE (S)-(+)-1-Benzyl-3-aminopyrrolidine (3R)-(+)-3-(METHYLAMINO)PYRROLIDINE (3R)-(+)-3-ACETAMIDOPYRROLIDINE Procainamide hydrochloride (3R)-(+)-3-(ETHYLAMINO)PYRROLIDINE 1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE 3-ACETAMIDOPYRROLIDINE 1-Benzyl-3-aminopyrrolidine N,N'-DIBENZYL-3-AMINOPYRROLIDINE Declopramide

  • CIS-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[2-METHYL-1-(PHENYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE
  • REL-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[(2R,3R)-2-METHYL-2-(PHENNYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE
  • NEMONAPRIDE
  • (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylami
  • benzamide,5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-py
  • cis-(+-)-rrolidinyl)
  • emonapride
  • inobenzamide
  • n-(2rs,3rs)-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylam
  • nobenzamide
  • ym-09151
  • Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, rel- (9CI)
  • Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, cis-
  • Emilace
  • YM 09151-2
  • N-[(2R,3R)-1-Benzyl-2-methylpyrrolidine-3-yl]-2-methoxy-4-(methylamino)-5-chlorobenzamide
  • C12915
  • cis-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[2-Methyl-1- (phennylMethyl)-3-pyrrolidinyl]benzaMide
  • rel-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[(2R,3R)-2-Methyl-1-(phennylMethyl)-3-pyrrolidinyl]benzaMide
  • cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-2-(phenylmethyl)-3-pyrrolidinyl]benzamide
  • (2R,3R)-nemonapride
  • N-(Cis-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
  • 75272-39-8
  • C21H26Cl23O2
  • Aromatics
  • Heterocycles
  • Heterocyclic Compounds
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
  • Dopamine receptor