HUMULONE

Product Name: HUMULONE
CAS No.: 26472-41-3
Chemical Name: HUMULONE
Synonyms: HUMULONE;α-bitter acid;[R,(-)]-Humulone;HUMULONE USP/EP/BP;Phloroglucinol Impurity T;(R)-Humulone DISCONTINUED;α-Bitter acid, α-Lupulic acid;Humulone, mixture of homologues;(6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one;(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone
CBNumber: CB3497674
Molecular Formula: C21H30O5
Formula Weight: 362.46
MOL File: 26472-41-3.mol

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HUMULONE Property

Melting point:: 65-66.5℃
alpha: D20 -212° (1.0 g in 15.5 g 96% alc)
Boiling point:: 414.06°C (rough estimate)
Density: 1.157±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.6120 (estimate)
storage temp.: −20°C
solubility: DMSO : 100 mg/mL (275.89 mM; Need ultrasonic)
form: Powder
pka: 4.50±1.00(Predicted)

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Safety

WGK Germany: 3
F: 10-23

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FH65574
Product name: Humulone
Packaging: 200ug
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH65574
Product name: Humulone
Packaging: 500ug
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH65574
Product name: Humulone
Packaging: 1mg
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH65574
Product name: Humulone
Packaging: 2mg
Price: $550
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH65574
Product name: Humulone
Packaging: 5mg
Price: $700
Updated: 2021/12/16

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HUMULONE Chemical Properties,Usage,Production

Uses

(R)-Humulone (CAS# 26471-41-3) can be used as a chemosensory receptor ligand.

Definition

ChEBI: Humulone is an optically active cyclic ketone consisting of 3,5,6-trihydroxycyclohexa-2,4-dien-1-one bearing two 3-methylbut-2-en-1-yl substituents at positions 4 and 6 as well as a 3-methylbutanoyl group at the 2-position. It has a role as an antibacterial drug, an antioxidant, a cyclooxygenase 2 inhibitor and a metabolite. It is a diketone, a triol, a cyclic ketone, an aromatic ketone and a tertiary alpha-hydroxy ketone.

target

IL Receptor | AP-1 | COX | p65 | NF-kB | IkB | VEGFR | Antifection | IKK

Purification Methods

Crystallise humulon from Et2O. It dissolves slightly in hot H2O but precipitates on cooling. It has max () 237 (13,760) and 282 (8,330) in EtOH. [Wollmer Chem Ber 49 780 1916, Carson J Am Chem Soc 73 4652 1951, Beilstein 8 II 537, 8 III 4034, 8 IV 3410.]

HUMULONE Preparation Products And Raw materials

Raw materials

Preparation Products

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HUMULONE Suppliers

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26472-41-3, HUMULONERelated Search:

ISOXANTHOHUMOL alpha-Cyperone beta-Sitosterol (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Asiaticoside B poricoic acid B bakkenolide A SWERTIANOLIN APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER Jaceosidin Polygalasaponin XXXI GARDENOSIDE dichotomitin caesalpin J HARRINGTONINE Isoastragaloside II poricoic acid A 3-methyl ester Poricoic acid A(F)

(6S)-3,5,6-trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dien-1-one

(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone

α-bitter acid

Humulone, mixture of homologues

α-Bitter acid, α-Lupulic acid

(6R)-2-(3-Methylbutyryl)-3,5,6-trihydroxy-4,6-bis(3-methyl-2-butenyl)-2,4-cyclohexadiene-1-one

(6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one

[R,(-)]-3,5,6-Trihydroxy-4,6-bis(3-methyl-2-butenyl)-2-(3-methyl-1-oxobutyl)-2,4-cyclohexadien-1-one

[R,(-)]-Humulone

HUMULONE

2,4-Cyclohexadien-1-one,3,5,6-trihydroxy-4,6-bis(3-methyl-2-buten-1-yl)-2-(3-methyl-1-oxobutyl)-, (6R)-

HUMULONE USP/EP/BP

(R)-Humulone DISCONTINUED

Phloroglucinol Impurity T

(R)-3,5,6-Trihydroxy-4,6-bis(3-methylbut-2-en-1-yl)-2-(3-methylbutanoyl)cyclohexa-2,4-dienone

26472-41-3

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