Chelerythrine
Description References- Product Name
- Chelerythrine
- CAS No.
- 34316-15-9
- Chemical Name
- Chelerythrine
- Synonyms
- Cheleritrine;helerythrine;CHELERYTHRINE;Einecs 251-930-0;Broussonpapyrine;Chelerythrine (6CI);478-03-5 (Hydroxide);3895-92-9 (Chloride);Chelerythrine chlori;Chelerythrine chloride
- CBNumber
- CB3506907
- Molecular Formula
- C21H18NO4+
- Formula Weight
- 348.37192
- MOL File
- 34316-15-9.mol
Chelerythrine Property
- Melting point:
- 195-205°C
- Boiling point:
- 496.37°C (rough estimate)
- Density
- 1.2985 (rough estimate)
- refractive index
- 1.5614 (estimate)
- storage temp.
- Desiccate at -20°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）
- form
- Solid
- color
- Light Yellow to Dark Orange
- Stability:
- Hygroscopic
- LogP
- -0.401 (est)
- CAS DataBase Reference
- 34316-15-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1330
- Product name
- Chelerythrine chloride
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $159
- Updated
- 2021/12/16
- Product number
- C3889-10
- Product name
- Chelerythrine Chloride
- Packaging
- 5mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 044663
- Product name
- Chelerythrine chloride
- Packaging
- 1mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- 169656
- Product name
- Chelerythrine Chloride
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 254958
- Product name
- Chelerythrine chloride
- Packaging
- 5mg
- Price
- $403
- Updated
- 2021/12/16
Chelerythrine Chemical Properties,Usage,Production
Description
Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.
References
https://en.wikipedia.org/wiki/Chelerythrine
https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9
https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ
Uses
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
Definition
ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Biological Activity
Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.
Purification Methods
Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.
Chelerythrine Preparation Products And Raw materials
Raw materials
Preparation Products
Chelerythrine Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
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- Tel
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- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from Chelerythrine manufacturers
- Product
- Chelerythrine; Chelerythrine chloride 34316-15-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 1%-98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-30
- Product
- Chelerythrine 34316-15-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-27
- Product
- chelerythrine 34316-15-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26