Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-

Product Name: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-
CAS No.: 2231085-26-8
Chemical Name: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-
Synonyms: N-Hydroxy Palbociclib;6-acetyl-8-cyclopentyl-2-((5-(4-hydroxypiperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-;6-Acetyl-8-cyclopentyl-2-((5-(4-hydroxypiperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one (Palbociclib Impurity)
CBNumber: CB35516819
Molecular Formula: C24H29N7O3
Formula Weight: 463.53
MOL File: 2231085-26-8.mol

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Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl- Property

Melting point:: >200°C (dec.)
Boiling point:: 742.2±70.0 °C(Predicted)
Density: 1.393±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.88±0.20(Predicted)
form: Solid
color: Light Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

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Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl- Chemical Properties,Usage,Production

Uses

N-Hydroxy Palbociclib is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl- Suppliers

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2231085-26-8, Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-Related Search:

4-[6-[(8-Cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylic acid tert-butyl ester Palbociclib Impurity N-Oxide 4-[6-[(8-cyclopentyl-6-ethenyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Palbociclib Impurity 87 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-6-vinylpyrido[2,3-d]pyrimidin-7(8H)-one Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 6-bromo-8-cyclopentyl-5-methyl-Pyrido[2,3-d]pyrimidine-2,7(1H,8H)-dione Palbociclib Impurity 91 Palbociclib Impurity I Palbociclib-025 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-2-[[5-(4-hydroxy-1-piperazinyl)-2-pyridinyl]amino]-5-methyl-

6-acetyl-8-cyclopentyl-2-((5-(4-hydroxypiperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one

N-Hydroxy Palbociclib

6-Acetyl-8-cyclopentyl-2-((5-(4-hydroxypiperazin-1-yl)pyridin-2-yl)amino)-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one (Palbociclib Impurity)

2231085-26-8