4-Bromoindole-3-carboxaldehyde

Product Name: 4-Bromoindole-3-carboxaldehyde
CAS No.: 98600-34-1
Chemical Name: 4-Bromoindole-3-carboxaldehyde
Synonyms: 4-BROMO-1H-INDOLE-3-CARBALDEHYDE;4-BROMO-3-FORMYLINDOLE;4-BROMO-3-FORMYL-1H-INDOLE;4-Bromoindole-3-carbaldehyde;4-BROMO-3-INDOLECARBALDEHYDE;4-BROMOINDOLE-3-CARBOXALDEHYDE;4-BROMOINDOLE-3-CARBOXYALDEHYDE;4-BoMo-1H-indole-3-carbaldehyde;4-Bromoindole-3-carboxaldehyde>4-Bromoindole-3-carboxaldehyde 98%
CBNumber: CB3665442
Molecular Formula: C9H6BrNO
Formula Weight: 224.05
MOL File: 98600-34-1.mol

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4-Bromoindole-3-carboxaldehyde Property

Melting point:: 179-180°C
Boiling point:: 395.6±22.0 °C(Predicted)
Density: 1.727±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Solid
pka: 14.57±0.30(Predicted)
color: White to Yellow
CAS DataBase Reference: 98600-34-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 21/22-36/37/38-36-22
Safety Statements: 22-26-36/37/39
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2773
Product name: 4-Bromoindole-3-carboxaldehyde
Purity: >96.0%(GC)(N)
Packaging: 1g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: B2773
Product name: 4-Bromoindole-3-carboxaldehyde
Purity: >96.0%(GC)(N)
Packaging: 5g
Price: $146
Updated: 2025/07/31

TRC

Product number: B686418
Product name: 4-Bromo-1H-indole-3-carbaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V0115
Product name: 4-Bromoindole-3-carboxaldehyde
Packaging: 1g
Price: $27
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B1568
Product name: 4-Bromo-3-formylindole
Purity: >98%
Packaging: 1g
Price: $30
Updated: 2021/12/16

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4-Bromoindole-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

In the field of medicinal chemistry, 4-bromoindole-3-carbaldehyde can be used to synthesize compounds with specific biological activities, such as building blocks for drug molecules.

Synthesis

52488-36-5

68-12-2

98600-34-1

In a 500 mL three-necked round-bottomed flask, 120 mL of anhydrous N,N-dimethylformamide (DMF) was added and the temperature of the reaction system was lowered to 0 °C. Under vigorous stirring, 11 mL (0.12 mol) of phosphoryl chloride (POCl3) was slowly added dropwise. After continuing stirring for 5 min, 10 g (0.048 mol, 95% purity) of 4-bromoindole dissolved in 20 g of anhydrous DMF was added slowly dropwise. After the dropwise addition was completed, the ice bath was removed and the reaction was continued for 1 hour. At this point, the reaction mixture transformed into a viscous suspension. Subsequently, 4.7 M potassium hydroxide solution was slowly added dropwise to the reaction suspension (dropwise acceleration was controlled to maintain the reaction temperature between 65-75 °C, and cooled if the temperature was too high). After the reaction has continued for 6 hours, 20 mL of saturated sodium bicarbonate solution is added and stirring is continued for 5 minutes. The reaction mixture was diluted with ethyl acetate, dried and concentrated under reduced pressure to give crude 4-bromoindole-3-carboxaldehyde 12 g. Immediately 2.5 mL of acetone was added and heated to reflux until dissolved. Subsequently, petroleum ether with a boiling range of 60-90 °C was added at a ratio of 11 mL/g of the crude product, and white fine needle-like crystals were immediately precipitated. The mixture was kept at a low temperature of -5°C for 10 minutes. After crystallization was complete, the mixture was filtered through a sand core funnel and washed twice with petroleum ether. If there is still uncrystallized product in the filtrate, the crystallization process can be repeated by evaporating the solvent. After four crystallizations, all the white crystals of 4-bromoindole-3-carboxaldehyde were combined and air-dried to give a final product of 10.3 g in 95% yield.

References

[1] Organic Letters, 2006, vol. 8, # 23, p. 5287 - 5289
[2] Journal of the American Chemical Society, 2009, vol. 131, # 31, p. 10796 - 10797
[3] Organic Letters, 2013, vol. 15, # 21, p. 5448 - 5451
[4] Patent: CN107935905, 2018, A. Location in patent: Paragraph 0029-0031; 0034; 0038
[5] Journal of Organic Chemistry, 2016, vol. 81, # 4, p. 1723 - 1730

4-Bromoindole-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 4-Bromoindole Phosphorus oxitrichloride Ethyl acetate Methanol Sodium hydroxide PETROLEUM ETHER

Preparation Products

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4-Bromoindole-3-carboxaldehyde Suppliers

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View Lastest Price from 4-Bromoindole-3-carboxaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromoindole-3-carboxaldehyde 98600-34-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-12

Career Henan Chemical Co

Product: 4-Bromoindole-3-carboxaldehyde 98600-34-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

98600-34-1, 4-Bromoindole-3-carboxaldehydeRelated Search:

Indole-3-acetic acid Indole-3-butyric acid cis-Octahydroisoindole 4-Bromoindole 3-Bromoanisole Indometacin Indole 6-BROMO-1H-INDOLE-2-CARBALDEHYDE 4-BROMO-1-(TERT-BUTOXYCARBONYL)-1H-INDOLE-3-CARBOXYLIC ACID 5-BROMOINDOLE-3-CARBOXALDEHYDE,5-BROMOINDOLE-3-CARBOXALDEHYDE, 98+%,5-Bromoindole-3-carboxaldehyde 97% 6-BROMOINDOLE-3-CARBOXALDEHYDE 7-BROMOINDOLE-3-CARBOXALDEHYDE 5-BROMOINDOLE-3-CARBOXALDEHYDE, N-BOC PROTECTED,5-Bromoindole-3-carboxaldehyde, N-BOC protected 98% Formaldehyde 5-BROMO-1H-INDOLE-2-CARBALDEHYDE 1H-INDOLE-1,3-DICARBOXYLIC ACID, 4-BROMO-, 1-(1,1-DIMETHYLETHYL)ESTER 1H-INDOLE-2-CARBOXYLIC ACID,4-BROMO-3-FORMYL-,ETHYL ESTER 4-BROMOINDOLE-3-CARBOXALDEHYDE, N-BOC PROTECTED

4-Bromoindole-3-carbaldehyde

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4-Bromo-1H-indole-3-carboxaldehyde 98%

4-Bromo-1H-indole-3-carboxaldehyde

4-Bromoindole-3-carboxaldehyde&gt

1H-Indole-3-carboxaldehyde, 4-bromo-

98600-34-1

C9H6NOBr

Indoles

Simple Indoles

Aldehyde

Building Blocks

Indoles

Simple Indoles

Indole