ChemicalBook > CAS DataBase List > PD 123319 ditrifluoroacetate

PD 123319 ditrifluoroacetate

Product Name
PD 123319 ditrifluoroacetate
CAS No.
130663-39-7
Chemical Name
PD 123319 ditrifluoroacetate
Synonyms
CS-953;PD 123,319;PD123319 TFA;PD123319, >=98%;(S)-(+)-PD 123319;ditrifluoroacetate;PD-123319 TFA salt;PD-123319 free base;PD 123319 ditrifluor;(S)-(+)-PD 123319|||PD123319
CBNumber
CB3669147
Molecular Formula
C31H32N4O3
Formula Weight
508.61
MOL File
130663-39-7.mol
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PD 123319 ditrifluoroacetate Property

Boiling point:
775.8±60.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 12 mg/mL
form 
powder
pka
2.80±0.20(Predicted)
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
1361
Product name
PD123319ditrifluoroacetate
Purity
≥99%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
Tocris
Product number
1361
Product name
PD123319ditrifluoroacetate
Purity
≥99%(HPLC)
Packaging
50
Price
$903
Updated
2021/12/16
Usbiological
Product number
462090
Product name
PD 123319
Packaging
10mg
Price
$439
Updated
2021/12/16
Usbiological
Product number
256179
Product name
PD 123319 ditrifluoroacetate
Packaging
10mg
Price
$480
Updated
2021/12/16
TRC
Product number
P217705
Product name
PD123319
Packaging
10mg
Price
$140
Updated
2021/12/16
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PD 123319 ditrifluoroacetate Chemical Properties,Usage,Production

Uses

PD 123319 is a selective non-peptide angiotensin AT2 receptor antagonist.

Definition

ChEBI: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively

Biological Activity

Potent, selective, non-peptide angiotensin AT 2 receptor antagonist. IC 50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.

References

[1] blankley c j, hodges j c, klutchko s r, et al. synthesis and structure-activity relationships of a novel series of non-peptide angiotensin ii receptor binding inhibitors specific for the at2 subtype. journal of medicinal chemistry, 1991, 34(11): 3248-3260.
[2] boulay g, servant g, luong t t, et al. modulation of angiotensin ii binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the dup-753-sensitive angiotensin ii receptor of bovine adrenal glomerulosa. molecular pharmacology, 1992, 41(4): 809-815.
[3] siragy h. angiotensin ii receptor blockers: review of the binding characteristics. the american journal of cardiology, 1999, 84(10): 3-8.

PD 123319 ditrifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PD 123319 ditrifluoroacetate manufacturers

Career Henan Chemical Co
Product
PD 123,319 DITRIFLUOROACETATE 130663-39-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

130663-39-7, PD 123319 ditrifluoroacetateRelated Search:

PD 173074 PD 166285 PD 166866 PD 0325901 xav-939 Cabozantinib 2-METHOXYESTRADIOL Vismodegib (GDC-0449) S3I-201 Rapamycin L-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID 4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID PD 123319 ditrifluoroacetate

  • 1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE
  • (3S)-9-[(4-DIMETHYLAMINO-3-METHYL-PHENYL)METHYL]-4-(2,2-DIPHENYLACETYL)-4,7,9-TRIAZABICYCLO[4.3.0]NONA-7,10-DIENE-3-CARBOXYLIC ACID
  • PD 123,319
  • PD 123,319 DITRIFLUOROACETATE
  • S(+)-1-[[4-(DIMETHYLAMINO)-3-METHYLPHENYL]METHYL]-5-(DIPHENYLACETYL)-4,5,6,7-TETRAHYDRO-1H-IMIDAZOL[4,5-C]PYRIDINE-6-CARBOXYLIC ACID DITRIFLUOROACETATE
  • PD 123,319 DITRIFLUOROACETATE POTENT AND SELECTIVE
  • 1-((4-(Dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4.5-c]pyridine-6-carboxyli
  • CS-953
  • pd 123,319 di(trifluoroacetate) salt
  • s-(+)-1-[(4-(dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
  • (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6α-carboxylic acid
  • (6S)-1-[4-(Dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • (6S)-1-[4-Dimethylamino-3-methylbenzyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6α-carboxylic acid
  • 1H-Imidazo(4,5-C)pyridine-6-carboxylic acid, 1-((4-(dimethylamino)-3-methylphenyl)methyl)-5-(diphenylacetyl)-4,5,6,7-tetrahydro-, (S)-
  • 1H-IMidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(diMethylaMino)-3-Methylphenyl]Methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
  • ditrifluoroacetate
  • (S)-(+)-PD 123319
  • (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • PD123319 TFA
  • 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid
  • PD123319, >=98%
  • PD-123319 TFA salt
  • PD 123319 ditrifluoroacetate USP/EP/BP
  • PD 123319 ditrifluor
  • PD-123319 free base
  • (S)-(+)-PD 123319|||PD123319
  • 130663-39-7
  • C31H32N4O32CF3CO2H
  • Inhibitors
  • Angiotensin