AY 9944 Property

Melting point:

288-293.5 °C(lit.)

storage temp. 

2-8°C

solubility 

DMSO: 14 mg/mL

form 

White solid

color 

white

Water Solubility 

Soluble to 50 mM in water

Sensitive 

Hygroscopic

Safety

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50/53

Safety Statements 

26-60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

GU7025000

HazardClass 

6.1

Toxicity

LD50 orl-mus: 155 mg/kg PSEBAA 139,100,72

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

AY 9944 Chemical Properties,Usage,Production

Uses

Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase. A sonic hedgehog inhibitor

Uses

Inhibitor of hedgehog (Hh) signaling

Biological Activity

Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .

Safety Profile

Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.

storage

room temperature (desiccate)

References

[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.
[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91.
[3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.