DEPMPO
- Product Name
- DEPMPO
- CAS No.
- 157230-67-6
- Chemical Name
- DEPMPO
- Synonyms
- DEPMPO;5-(Diethoxyphosphoryl)-;5-(DIETHYLPHOSPHONO)-5-METHYL-1-PYRROLINE N-OXIDE;5-(DIETHOXYPHOSPHORYL)-5-METHYL-1-PYRROLINE-N-OXIDE;5-(DIETHOXYPHOSPHONYL)-5-METHYL-1-PYRROLINE-N-OXIDE;5-(Diethylphosphono)-5-methyl-1-pyrrolineN-Oxide>5-(Diethylphosphono)-5-methyl-1-pyrroline N-Oxide;2-DIETHYLPHOSPHONO-2-METHYL-3,4-DIHYDRO-2H-PYRROLE 1-OXIDE;(2-METHYL-3,4-DIHYDRO-1-OXIDE-2H-PYRROL-2-YL)DIETHYLPHOSPHONATE;(3,4-Dihydro-2-methyl-1-oxido-2H-pyrrol-2-yl)-phosphonic acid diethyl ester
- CBNumber
- CB3675728
- Molecular Formula
- C9H18NO4P
- Formula Weight
- 235.22
- MOL File
- 157230-67-6.mol
DEPMPO Property
- Boiling point:
- 412.4±34.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Freezer
- solubility
- Soluble in Water or Ethanol.
- form
- Colorless to light yellow oil.
- pka
- 1.74±0.40(Predicted)
- color
- Pale yellow
- Stability:
- Hygroscopic Oil, Light Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 10006435
- Product name
- DEPMPO
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 10006435
- Product name
- DEPMPO
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $513
- Updated
- 2024/03/01
- Product number
- 10006435
- Product name
- DEPMPO
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $961
- Updated
- 2024/03/01
- Product number
- D442000
- Product name
- 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- D442000
- Product name
- 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
- Packaging
- 5mg
- Price
- $95
- Updated
- 2021/12/16
DEPMPO Chemical Properties,Usage,Production
Description
DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicals both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent.
Chemical Properties
DEPMPO is Pale Yellow Oil
Uses
DEPMPO is a spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO
Uses
DEPMPO is the most efficient spin trap for the in vitro detection of O-, N-, S- and C-centered free radicals both invitro and invivo. It has a longer life-time than DMPO and can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. It is less lipophilic (Kp=0.16) than DIPPMPO.
References
1) Liu et al. (1999), Evaluation of DEPMPO as a spin trapping agent in biological systems; Free Radic. Biol. Med., 26 714 2) Shi et al. (2005), Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species; Arch. Biochem. Biophys., 437 59 3) Culcasi et al. (2012), EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation; Chem. Biol. Interact., 199 161 4) Tampieri et al. (2019), Comment on “Water Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos; ACS Sens. E-pub. Ahead of Print [Focus Citation]