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PYRILAMINE MALEATE

Product Name
PYRILAMINE MALEATE
CAS No.
59-33-6
Chemical Name
PYRILAMINE MALEATE
Synonyms
paramal;pymafed;antihist;minihist;Histatex;pyraninyl;renstamin;BiMaleate;pyramaleate;stangenmaleate
CBNumber
CB3677373
Molecular Formula
C21H27N3O5
Formula Weight
401.46
MOL File
59-33-6.mol
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PYRILAMINE MALEATE Property

Melting point:
101-103°C
storage temp. 
2-8°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent).
form 
neat
Water Solubility 
Soluble in water at 100mg/ml
λmax
310nm(EtOH)(lit.)
Merck 
14,7984
Stability:
Stability Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference
59-33-6(CAS DataBase Reference)
EPA Substance Registry System
Pyrilamine maleate (59-33-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
RTECS 
UT1225000
TSCA 
Yes
HS Code 
2933399090
Toxicity
LD50 orally in mice: 338 mg/kg (Hunziker)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5514
Product name
Pyrilamine maleate salt
Packaging
5g
Price
$62.1
Updated
2021/03/22
Sigma-Aldrich
Product number
M0500000
Product name
Mepyramine maleate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1588004
Product name
Pyrilamine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
P2369
Product name
Pyrilamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$37
Updated
2021/03/22
TCI Chemical
Product number
P2369
Product name
Pyrilamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$107
Updated
2021/03/22
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PYRILAMINE MALEATE Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Uses

A histamine H1 receptor antagonist

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

General Description

Pyrilamine, 2-[4-methoxybenzyl[2-dimethylamino)ethyl]-amino]pyridine, is available as theacid maleate salt (1:1), which is a white crystalline powderwith a faint odor and a bitter, saline taste. The salt is solublein water (1:0.4) and freely soluble in alcohol. A 10% solutionhas a pH of approximately 5. At a pH of 7.5 or above,the free base begins to precipitate.
Pyrilamine differs structurally from tripelennamine byhaving a methoxy group in the para position of the benzylradical. It differs from its more toxic and less potent precursorphenbenzamine (Antergan) by having a 2-pyridyl groupon the nitrogen atom in place of a phenyl group.
Clinically, pyrilamine and tripelennamine are consideredamong the less potent antihistaminics. They are highly potent,however, in antagonizing histamine-induced contractionsof guinea pig ileum. Because of the pronounced localanesthetic action, the drug should not be chewed, but takenwith food.

General Description

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reactions

Water soluble.

Reactivity Profile

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Fire Hazard

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biological Activity

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects; predominantly used in horses.

PYRILAMINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRILAMINE MALEATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
BOC Sciences
Tel
Email
info@bocsci.com
Country
United States
ProdList
9942
Advantage
65
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-3668-0489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28438
Advantage
80
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View Lastest Price from PYRILAMINE MALEATE manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
PYRILAMINE MALEATE 59-33-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
30 Tons
Release date
2021-07-06
Shaanxi Dideu Medichem Co. Ltd
Product
PyrilaMine Maleate Salt 59-33-6
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-08
Dideu Industries Group Limited
Product
PYRILAMINE MALEATE USP/EP/BP 59-33-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-16

59-33-6, PYRILAMINE MALEATERelated Search:


  • MEPYRAMINE MALEATE
  • MEPYRAMINE MALEATE SALT
  • n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate
  • neo-anterganmeleate
  • n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate
  • paramal
  • paraminylmaleate
  • pymafed
  • pyramaleate
  • pyranilaminemaleate
  • pyraninyl
  • pyrilaminemaleatecrystalline
  • renstamin
  • stangenmaleate
  • statominmaleate
  • thylogenmaleate
  • PYRILAMINE MALEATE METHANOL SOLUTION
  • 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate)
  • 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE
  • PYRILAMINE MALEATE
  • PYRILAMINE MALEATE SALT
  • PYRANISAMINE MALEATE
  • N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE
  • N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT
  • antihist
  • diaminidemaleate
  • minihist
  • n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine
  • n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate
  • (z)-2-butenedioat
  • 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1)
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1)
  • 2786r.p.maleate
  • 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-(
  • anisopyradamine
  • anthisanmaleate
  • 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1)
  • PYRILAMINEMALEATE,USP
  • Histatex
  • Pyrilaminmaleat
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate
  • 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP
  • PYRILAMINE MALEATE USP/NF
  • Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt
  • Pyrilamine Maleate (200 mg)
  • BiMaleate
  • N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate
  • N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate
  • N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate
  • Mepyramine maleate CRS
  • N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate
  • N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate
  • PyrilamineMaleateSal
  • N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
  • PYRILAMINE MALEATE USP/EP/BP
  • 59-33-6
  • C17H23N3OC4H4O4