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PYRILAMINE MALEATE

Product Name
PYRILAMINE MALEATE
CAS No.
59-33-6
Chemical Name
PYRILAMINE MALEATE
Synonyms
paramal;pymafed;antihist;minihist;Histatex;pyraninyl;renstamin;BiMaleate;pyramaleate;stangenmaleate
CBNumber
CB3677373
Molecular Formula
C21H27N3O5
Formula Weight
401.46
MOL File
59-33-6.mol
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PYRILAMINE MALEATE Property

Melting point:
101-103°C
storage temp. 
2-8°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent).
form 
Solid
color 
White
Water Solubility 
Soluble in water at 100mg/ml
λmax
310nm(EtOH)(lit.)
Merck 
14,7984
Stability:
Stability Combustible. Incompatible with strong oxidizing agents.
LogP
2.751 (est)
CAS DataBase Reference
59-33-6(CAS DataBase Reference)
EPA Substance Registry System
Pyrilamine maleate (59-33-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
RTECS 
UT1225000
TSCA 
Yes
HS Code 
2933399090
Toxicity
LD50 orally in mice: 338 mg/kg (Hunziker)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5514
Product name
Pyrilamine maleate salt
Packaging
5g
Price
$74.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1588004
Product name
Pyrilamine maleate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$360
Updated
2024/03/01
TCI Chemical
Product number
P2369
Product name
Pyrilamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$39
Updated
2024/03/01
TCI Chemical
Product number
P2369
Product name
Pyrilamine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$113
Updated
2024/03/01
Alfa Aesar
Product number
J63247
Product name
Pyrilamine maleate
Packaging
25g
Price
$124.65
Updated
2024/03/01
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PYRILAMINE MALEATE Chemical Properties,Usage,Production

Description

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.

Chemical Properties

solid

Uses

Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

Uses

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Uses

A histamine H1 receptor antagonist

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

General Description

Pyrilamine, 2-[4-methoxybenzyl[2-dimethylamino)ethyl]-amino]pyridine, is available as theacid maleate salt (1:1), which is a white crystalline powderwith a faint odor and a bitter, saline taste. The salt is solublein water (1:0.4) and freely soluble in alcohol. A 10% solutionhas a pH of approximately 5. At a pH of 7.5 or above,the free base begins to precipitate.
Pyrilamine differs structurally from tripelennamine byhaving a methoxy group in the para position of the benzylradical. It differs from its more toxic and less potent precursorphenbenzamine (Antergan) by having a 2-pyridyl groupon the nitrogen atom in place of a phenyl group.
Clinically, pyrilamine and tripelennamine are consideredamong the less potent antihistaminics. They are highly potent,however, in antagonizing histamine-induced contractionsof guinea pig ileum. Because of the pronounced localanesthetic action, the drug should not be chewed, but takenwith food.

General Description

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reactions

Water soluble.

Reactivity Profile

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Fire Hazard

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biological Activity

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects; predominantly used in horses.

storage

Room temperature

PYRILAMINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRILAMINE MALEATE Suppliers

Austria 1 Belgium 2 Brazil 1 Canada 2 China 81 Europe 2 France 3 Germany 5 India 45 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 United Arab Emirates 1 United Kingdom 8 United States 39 USA 1 Global 198
Clearsynth Labs Limited
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View Lastest Price from PYRILAMINE MALEATE manufacturers

Career Henan Chemical Co
Product
PYRILAMINE MALEATE 59-33-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

59-33-6, PYRILAMINE MALEATERelated Search:

FORMANILIDE 4-Aminodiphenylamine 2-Benzylaminopyridine 2-(4-Methoxybenzylamino)pyridine PYRILAMINE 2-DIETHYLAMINOPYRIDINE Tripelennamine N,N'-Dimethyl-1,2-ethanediamine (METHOXYMETHYL)DIPHENYLPHOSPHINE OXIDE N,N-Dimethylethylenediamine PYRILAMINE MALEATE Ammonium hydrogen maleate N-METHYL-N-PYRIDIN-2-YLETHANE-1,2-DIAMINE N-2-Pyridinyl-1,2-ethanediamine N'-(5-AMINOPENTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE, DIMALEATE SALT 2-(ETHYLMETHYLAMINO)PYRIDINE N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine [[(2-aminoethyl)amino]methyl]phenol

  • MEPYRAMINE MALEATE
  • MEPYRAMINE MALEATE SALT
  • n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate
  • neo-anterganmeleate
  • n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate
  • paramal
  • paraminylmaleate
  • pymafed
  • pyramaleate
  • pyranilaminemaleate
  • pyraninyl
  • pyrilaminemaleatecrystalline
  • renstamin
  • stangenmaleate
  • statominmaleate
  • thylogenmaleate
  • PYRILAMINE MALEATE METHANOL SOLUTION
  • 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate)
  • 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE
  • PYRILAMINE MALEATE
  • PYRILAMINE MALEATE SALT
  • PYRANISAMINE MALEATE
  • N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE
  • N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT
  • antihist
  • diaminidemaleate
  • minihist
  • n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine
  • n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate
  • (z)-2-butenedioat
  • 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1)
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1)
  • 2786r.p.maleate
  • 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-(
  • anisopyradamine
  • anthisanmaleate
  • 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1)
  • PYRILAMINEMALEATE,USP
  • Histatex
  • Pyrilaminmaleat
  • 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate
  • 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP
  • PYRILAMINE MALEATE USP/NF
  • Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt
  • Pyrilamine Maleate (200 mg)
  • BiMaleate
  • N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate
  • N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate
  • N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate
  • Mepyramine maleate CRS
  • N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate
  • N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate
  • PyrilamineMaleateSal
  • N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
  • PYRILAMINE MALEATE USP/EP/BP
  • Mepyramine maleateQ: What is Mepyramine maleate Q: What is the CAS Number of Mepyramine maleate Q: What is the storage condition of Mepyramine maleate Q: What are the applications of Mepyramine maleate
  • Pyrilamine Maleate (1588004)