ChemicalBook > CAS DataBase List > 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE

4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE

Product Name: 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
CAS No.: 2963-77-1
Chemical Name: 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
Synonyms: AKOS BB-7980;ASISCHEM T31097;imidazol-CHEMBRDG-BB 4101671;TIMTEC-BB SBB000485;4-(2-Benzimidazolyl)aniline;4-(1H-Benzo[d]imidazol-2-yl);2-[p-Aminophenyl]benzimidazole;2-(p-Aminophenyl)benzimidazole;2-(4-Aminophenyl)benzimidazole
CBNumber: CB3685387
Molecular Formula: C13H11N3
Formula Weight: 209.25
MOL File: 2963-77-1.mol

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4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Property

Melting point:: 248.0 to 252.0 °C
Boiling point:: 466.3±47.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 11.77±0.10(Predicted)
color: White to Light yellow to Light orange
λmax: 314nm(HCl aq.)(lit.)

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Safety

Hazard Codes: Xi
HS Code: 2933.99.8290
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

H330Fatal if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R702587
Product name: 4-(1H-BENZIMIDAZOL-2-YL)ANILINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: R702587
Product name: 4-(1H-BENZIMIDAZOL-2-YL)ANILINE
Purity: AldrichCPR
Packaging: 25MG
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: B5710
Product name: 4-(1H-Benzimidazol-2-yl)aniline
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $169
Updated: 2025/07/31

TCI Chemical

Product number: B5710
Product name: 4-(1H-Benzimidazol-2-yl)aniline
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $590
Updated: 2025/07/31

TRC

Product number: B502225
Product name: 4-(1H-Benzimidazol-2-yl)aniline
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 39, p. 3375, 1996 DOI: 10.1021/jm9600959

Synthesis

150-13-0

95-54-5

2963-77-1

The reaction was carried out with 4-aminobenzoic acid (5 g, 5.78 mmol) and o-phenylenediamine (3.9 g, 3.68 mmol) in polyphosphoric acid (12.5 g) with stirring at 200 °C for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into crushed ice. Subsequently, the precipitate was stirred in cold water. The pH was adjusted with ammonium hydroxide solution to 7. The solid product was collected by filtration and washed several times with methanol. Finally, the target compound 4-(1H-benzimidazol-2-yl)aniline (5) was purified as a white solid by silica gel column chromatography using ethyl acetate: hexane (4:1) as eluent. Yield: 82%; Melting point: 207-209 °C; 1H NMR (400 MHz, DMSO-d6): δ= 7.96 (d, 2H, J = 8.72 Hz, ArH), 7.55-7.51 (m, 2H, ArH), 7.16-7.14 (m, 2H, ArH), 6.75 (d, 2H, J = 8.24 Hz, ArH) , 4.45 (bs, 2H, NH2); 13C NMR (100 MHz, DMSO-d6): δ= 152.2,148.4,127.5,120.9,118.6,113.8 (ArC); MS (ESI), m/z: 210.2 (M++1).

References

[1] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 1, p. 115 - 117
[2] Chinese Chemical Letters, 2011, vol. 22, # 3, p. 296 - 299
[3] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 24 - 35
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 59 - 69
[5] Journal of the Chilean Chemical Society, 2012, vol. 57, # 2, p. 1122 - 1125,4

4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE Suppliers

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2963-77-1, 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINERelated Search:

2-(4-Aminophenyl)-1H-benzimidazol-5-amine 2-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 2-(4-AMINO-3-CHLORO-PHENYL)-4,6-DICHLORO-1 H-BENZOIMIDAZOL-5-YLAMINE TIMTEC-BB SBB010040 2-(4-AMINO-PHENYL)-1 H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID DIHYDROCHLORIDE N-[4-(2-BENZIMIDAZOLYL)PHENYL]MALEIMIDE 4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 2-(P-N,N-DIMETHYLAMINOPHENYL)-1H-BENZOIMIDAZOLE RO 90-7501 4-(5-CHLORO-1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 4-AMINO-N-[4-(1 H-BENZOIMIDAZOL-2-YL)-PHENYL]-BENZAMIDE 5-METHYL-2-(4-NITRO-PHENYL)-1H-BENZOIMIDAZOLE 2-(4-DIMETHYLAMINO-PHENYL)-1 H-BENZOIMIDAZOL-5-YLAMINE 5-nitro-2-(4-nitrophenyl)-1H-benzimidazole 4-(5-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 4-(5-BROMO-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE 2-BENZOIMIDAZOL-1-YL-PHENYLAMINE 4-(5-METHOXY-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE

4-(1H-benzimidazol-2-yl)aniline(SALTDATA: FREE)

2-(p-Aminophenyl)benzimidazole

2-[p-Aminophenyl]benzimidazole

ASISCHEM T31097

CHEMBRDG-BB 4101671

4-(1H-BENZIMIDAZOL-2-YL)ANILINE

4-(1H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE

4-(1H-BENZIMIDAZOL-2-YL) PHENYLAMINE

AKOS BB-7980

TIMTEC-BB SBB000485

4-(1H-Benzo[d]imidazol-2-yl)

4-(1H-benzo[d]imidazol-2-yl)aniline

4-(1H-benzo[d]imidazol-2-yl)benzenamine

Benzenamine, 4-(1H-benzimidazol-2-yl)-

2-(4-Aminophenyl)benzimidazole

imidazol-&#8203

4-(2-Benzimidazolyl)aniline

2963-77-1