SPECTINOMYCIN DIHYDROCHLORIDE

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SPECTINOMYCIN DIHYDROCHLORIDE

Product Name: SPECTINOMYCIN DIHYDROCHLORIDE
CAS No.: 21736-83-4
Chemical Name: SPECTINOMYCIN DIHYDROCHLORIDE
Synonyms: SPECTINOMYCIN HYDROCHLORIDE;M 141;stanilo;U-18409AE;NSC 248616;Spectacomycin;SPECTINOMYCIN 2HCL;SPECTINOMYCIN DIHYDROC;Spectinomycin (50mg/ml);Methomycin hydrochloride
CBNumber: CB3690961
Molecular Formula: C14H25ClN2O7
Formula Weight: 368.81
MOL File: 21736-83-4.mol

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SPECTINOMYCIN DIHYDROCHLORIDE Property

Melting point:: 194°C
storage temp.: Inert atmosphere,2-8°C
solubility: H₂O: 50 mg/mL, clear, faintly yellow
form: powder
color: White to Off-White

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Safety

WGK Germany: 2
RTECS: WG7400000
F: 10
Toxicity: monkey,LD50,oral,500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: S680250
Product name: SpectinomycinDihydrochloride
Packaging: 100mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-2544
Product name: Spectinomycindihydrochloride
Purity: ≥98.0%
Packaging: 1g
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-2544
Product name: Spectinomycindihydrochloride
Purity: ≥98.0%
Packaging: 5g
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 2725AH
Product name: Spectinomycindihydrochloridehydrate
Packaging: 5g
Price: $121
Updated: 2021/12/16

ChemScene

Product number: CS-2544
Product name: Spectinomycindihydrochloride
Purity: ≥98.0%
Packaging: 25g
Price: $220
Updated: 2021/12/16

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SPECTINOMYCIN DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

SPECTINOMYCIN DIHYDROCHLORIDE is White Powder

Uses

SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.

Uses

Antibacterial;Ribosomal protein

Definition

SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.

Clinical Use

The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.

Purification Methods

The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].

SPECTINOMYCIN DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SPECTINOMYCIN DIHYDROCHLORIDE manufacturers

Hebei ZB Gamay Biological Technology Co.,Ltd

Product: SpectinoMycin Dihydrochloride 21736-83-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 784U/mg
Supply Ability: 1000kg
Release date: 2022-11-22

shandong perfect biotechnology co.ltd

Product: Spectinomycin dihydrochloride 21736-83-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1000kg
Release date: 2023-08-04

Hebei Weibang Biotechnology Co., Ltd

Product: SPECTINOMYCIN DIHYDROCHLORIDE 21736-83-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

21736-83-4, SPECTINOMYCIN DIHYDROCHLORIDERelated Search:

Ascomycin Tetracycline Metronidazole Lincomycin hydrochloride Doxycycline Ceftriaxone sodium Amoxicillin Norfloxacin Ribostamycin sulfate Ciprofloxacin hydrochloride S3I-201 Doxycycline hyclate Phenylhydrazine hydrochloride Norvoncomycin hydrochloride BETAZOLE HYDROCHLORIDE Metacycline hydrochloride Xylazine Hydrochloride Hydralazine hydrochloride

8-beta,9-alpha,9a-alpha,10a-beta))-t

8-bis(methylamino)-,dihydrochloride,(2r-(2-alpha,4a-beta,5a-beta,6-beta,7-be

(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one Hydrochloride

SpectinoMycinHydrochloride for Injection

4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-, hydrochloride(1:2), (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-

(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one, hydrochloride (1:2)

Raw Material Spectinomycin Dihydrochloride / Spectinomycin HCL CAS 21736-83-4

Spectinomycin dihydrochloride, >98%

SPECTINOMYCIN DIHYDROC

U-18409AE

SPECTINOMYCIN DIHYDROCHLORIDE

SPECTINOMYCIN HYDROCHLORIDE

SPECTINOMYCIN 2HCL

ACTINOSPECTACIN DIHYDROCHLORIDE

stanilo

SPECTINOMYCIN READY MADE SOLUTION

Spectinomycin2HClpentahydrate

SPECTINOMYCINHYDROCHLORIDEANHYDROUS

4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (9CI)

4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]- (8CI)

NSC 248616

M 141

Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder

SPECTINOMYCIN DIHYDROCHLORIDE USP/EP/BP

(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride

Methanomycin hydrochloride

Spectinomycin (50mg/ml)

Spectacomycin

(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one hydrochloride

Methomycin hydrochloride

SPECTINOMYCIN DIHYDROCHLORIDEv

Gentamicin hydrochloride

21736-83-4

21736-83-5

C14H26Cl2N2O7

C14H24N2O72ClH

C14H24N2O7HClH2O

C14H25ClN2O7

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