ChemicalBook > CAS DataBase List > 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

Uses

Product Name: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS No.: 5952-92-1
Chemical Name: 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Synonyms: AKOS B000227;AKOS PAO-0317;TIMTEC-BB SBB000052;IFLAB-BB F2124-0619;ART-CHEM-BB B000227;ASINEX-REAG BAS 10145669;4-Carboxy-1-methyl-1H-pyrazole;1-methyl-4-pyrazolecarboxylic acid;1-methylpyrazole-4-carboxylic acid;1-Bethylpyrazole-4-carboxylic acid
CBNumber: CB3696004
Molecular Formula: C5H6N2O2
Formula Weight: 126.11
MOL File: 5952-92-1.mol

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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Property

Melting point:: 203-208°C
Boiling point:: 306.9±15.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.88±0.10(Predicted)
form: Powder or Crystalline Powder
color: White to pale yellow
InChI: InChI=1S/C5H6N2O2/c1-7-3-4(2-6-7)5(8)9/h2-3H,1H3,(H,8,9)
InChIKey: UPPPWUOZCSMDTR-UHFFFAOYSA-N
SMILES: N1(C)C=C(C(O)=O)C=N1
CAS DataBase Reference: 5952-92-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 682063
Product name: 1-Methyl-1H-pyrazole-4-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $292
Updated: 2023/06/20

TCI Chemical

Product number: M2224
Product name: 1-Methylpyrazole-4-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: M2224
Product name: 1-Methylpyrazole-4-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $337
Updated: 2025/07/31

TRC

Product number: M320910
Product name: 1-Methyl-1H-pyrazole-4-carboxylic acid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 028252
Product name: 1-Methyl-1H-pyrazole-4-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

1-Methylpyrazol-4-carboxylic acid is an organic intermediate that can be used to prepare an amide-substituted xanthine derivative, 1-methyl-1H-pyrazol-4-carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluoro-benzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-methyl-amide, which has gluconeogenesis-regulating activity.

Definition

ChEBI: 1-methyl-pyrazole-4-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group at position 4. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.

Synthesis

85290-80-8

5952-92-1

General procedure for the synthesis of 1-methyl-1H-pyrazole-4-carboxylic acid from ethyl 1-methyl-1H-pyrazole-4-carboxylate: 1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (20.2 g, 131 mmol) and sodium hydroxide (6.3 g, 158 mmol) were dissolved in 200 mL of anhydrous ethanol and heated to reflux for 2 h. The stirring process was continued at room temperature for the subsequent 18 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in water and the aqueous solution was washed with ether and subsequently acidified with concentrated hydrochloric acid. The precipitated solid was collected, filtered, washed with water and dried in air to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.

References

[1] Patent: US5498630, 1996, A
[2] Patent: US2004/14766, 2004, A1
[3] Patent: US2004/14766, 2004, A1
[4] Patent: WO2003/106459, 2003, A1. Location in patent: Page 116; 156

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Sodium hydride Nitrogen Ethanol Ethyl formate Sodium sulfate Sodium chloride Sodium Tetrahydrofuran Diethyl ether Ammonium chloride Ethyl acetate Hydrochloric acid Dichloromethane HYDRAZINE Sodium hydroxide Ethyl propiolate Magnesium sulfate Iodomethane

Preparation Products

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1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Methyl-1H-Pyrazole-4-Carboxylic Acid 5952-92-1
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1-Methyl-1h-Pyrazole-4-Carboxylic Acid 5952-92-1
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-1H-pyrazole-4-carboxylic acid 5952-92-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

5952-92-1, 1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACIDRelated Search:

5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-AMINO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 1-METHYL-5-NITRO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 5-TRIFLUOROMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 3-methyl-1H-pyrazole-5-carboxylate 4-BROMO-5-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-Methyl-1H-pyrazole-3-carboxylic acid 4-CHLORO-1-METHYL-3-(2-METHYLPROPYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 4-CHLORO-3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 4-CHLORO-3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 4-CHLORO-1-ETHYL-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 1-Methyl-1H-pyrazole-5-carboxylic acid 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID

IFLAB-BB F2124-0619

ASINEX-REAG BAS 10145669

ART-CHEM-BB B000227

AKOS PAO-0317

AKOS B000227

1-methylpyrazole-4-carboxylic acid

1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

TIMTEC-BB SBB000052

1-methyl-4-pyrazolecarboxylic acid

1-methyl-1H-pyrazole-4-carboxylic acid(SALTDATA: FREE)

4-Carboxy-1-methyl-1H-pyrazole

1-Bethylpyrazole-4-carboxylic acid

1-Methyl-1H-pyrazole-4-carboxylic acid 97%

1H-pyrazole-4-carboxylic acid, 1-methyl-

1-Methylpyrazole-4-carboxylicAcid&gt

1-Methyl-1<i>H</i>-pyrazole-4-carboxylic acid

5952-92-1

5259-92-1

Building Blocks

C3 to C5

Chemical Synthesis

Heterocyclic Building Blocks

Pyrazoles