1-Methyl-1H-pyrazole-5-carboxylic acid
- Product Name
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- CAS No.
- 16034-46-1
- Chemical Name
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- Synonyms
- SKL263;AKOS B000141;AKOS PAO-0505;CHEMBRDG-BB 4401287;ART-CHEM-BB B000141;TIMTEC-BB SBB000007;1-Methyl-1H-pyrazole-5-ca...;1-Methyl-pyrazole-5-carboxylicacid;2-Methylpyrazole-3-carboxylic acid;1-Methyl-5-pyrazolecarboxylic acid
- CBNumber
- CB8467029
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 16034-46-1.mol
1-Methyl-1H-pyrazole-5-carboxylic acid Property
- Melting point:
- 220-225 °C
- Boiling point:
- 306.9±15.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.03±0.25(Predicted)
- color
- White to Almost white
- λmax
- 259nm(MeOH)(lit.)
- InChI
- 1S/C5H6N2O2/c1-7-4(5(8)9)2-3-6-7/h2-3H,1H3,(H,8,9)
- InChIKey
- JREJQAWGQCMSIY-UHFFFAOYSA-N
- SMILES
- Cn1nccc1C(O)=O
- CAS DataBase Reference
- 16034-46-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 722138
- Product name
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $197
- Updated
- 2025/07/31
- Product number
- M2494
- Product name
- 1-Methylpyrazole-5-carboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- M2494
- Product name
- 1-Methylpyrazole-5-carboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $90
- Updated
- 2025/07/31
- Product number
- M320925
- Product name
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR5218
- Product name
- 1-Methyl-1H-pyrazole-5-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $53
- Updated
- 2021/12/16
1-Methyl-1H-pyrazole-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to yellow solid
Uses
1-Methyl-5-pyrazolecarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: 1-methyl-pyrazole-5-carboxylic acid is a member of the class of pyrazoles that is N-methylpyrazole substituted by a carboxy group substituents at position 5. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It is functionally related to a N-methylpyrazole.
Synthesis
930-36-9
124-38-9
16034-46-1
1-Methyl-1H-pyrazole (2.0 g, 24.4 mmol) was dissolved in tetrahydrofuran (THF, 30 mL) at room temperature. The reaction mixture was cooled to -78 °C under nitrogen protection, followed by slow dropwise addition of n-butyllithium (n-BuLi, 10.72 mL, 26.8 mmol). The reaction temperature of -78 °C was maintained and the reaction mixture was stirred for 2 h. Subsequently, it was gradually warmed up to room temperature and stirring was continued for 1 h. The reaction temperature was maintained at -78 °C. Under the condition of maintaining the reaction temperature, dry carbon dioxide gas was passed into the reaction solution for about 5 minutes. The reaction mixture continued to be stirred at room temperature for 1 hour. Subsequently, water (30 mL) was added to the reaction mixture to quench the reaction and dilute the mixture. The reaction mixture was extracted with dichloromethane. After precipitation of a large amount of solid from the acidic aqueous phase, the separation was carried out by filtration. The resulting filter cake was dried to give a final 1.5 g of white solid product 1-methyl-1H-pyrazole-5-carboxylic acid in 48.8% yield.
References
[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 650 - 654
[2] Patent: CN105384739, 2016, A. Location in patent: Paragraph 0345; 0346; 0347
[3] Patent: WO2009/71705, 2009, A1. Location in patent: Page/Page column 39
[4] Patent: WO2009/71706, 2009, A1. Location in patent: Page/Page column 48
[5] Patent: US2008/242661, 2008, A1. Location in patent: Page/Page column 25
1-Methyl-1H-pyrazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methyl-1H-pyrazole-5-carboxylic acid manufacturers
- Product
- 1-Methyl-1H-pyrazole-5-carboxylic acid 16034-46-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-19