2-Amino-3-benzyloxypyridine
- Product Name
- 2-Amino-3-benzyloxypyridine
- CAS No.
- 24016-03-3
- Chemical Name
- 2-Amino-3-benzyloxypyridine
- Synonyms
- 3-(BENZYLOXY)PYRIDIN-2-AMINE;NSC 298538;TIMTEC-BB SBB000394;2-Amino-3-benzyloxyp;Indacaterol Impurity 76;3-Benzyloxy-2-pyridylamin;3-Benzyloxy-2-pyridylamine;2-AMINO-3-BENZYLOXYPYRIDINE;3-Benzyloxy-2-aminopyridine;4-(Benzyloxy)-2-pyridinamine
- CBNumber
- CB3703762
- Molecular Formula
- C12H12N2O
- Formula Weight
- 200.24
- MOL File
- 24016-03-3.mol
2-Amino-3-benzyloxypyridine Property
- Melting point:
- 92-94 °C (lit.)
- Boiling point:
- 337.96°C (rough estimate)
- Density
- 1.1131 (rough estimate)
- refractive index
- 1.6660 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 8.40±0.10(Predicted)
- color
- Green to brown
- BRN
- 392674
- InChI
- InChI=1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)
- InChIKey
- NMCBWICNRJLKKM-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC=C1OCC1=CC=CC=C1
- CAS DataBase Reference
- 24016-03-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinamine, 3-(phenylmethoxy)-(24016-03-3)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-24/25-36/37/39-22,26-36
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29221985
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 144487
- Product name
- 2-Amino-3-benzyloxypyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $102
- Updated
- 2025/07/31
- Product number
- 144487
- Product name
- 2-Amino-3-benzyloxypyridine
- Purity
- 99%
- Packaging
- 25g
- Price
- $219
- Updated
- 2023/06/20
- Product number
- A2080
- Product name
- 2-Amino-3-benzyloxypyridine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- A2080
- Product name
- 2-Amino-3-benzyloxypyridine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- A600225
- Product name
- 2-Amino-3-benzyloxypyridine
- Packaging
- 100g
- Price
- $265
- Updated
- 2021/12/16
2-Amino-3-benzyloxypyridine Chemical Properties,Usage,Production
Chemical Properties
Brown crystalline powder
Uses
2-Amino-3-benzyloxypyridine is used in preparation of pyridinyl/pyridazinyloxymethyl substituted Raf kinase inhibitors.
Uses
2-Amino-3-benzyloxypyridine was used in the synthesis of 1-acetyl-2-[2-(3-benzyloxypyridinyl)]iminoimidazolidine.
General Description
2-Amino-3-benzyloxypyridine on condensation with diethyl ethoxymethylene malonate affords 9-benzyloxy-3-ethoxycarbonylpyrido[1,2-a]pyrimidin-4-one.
Biochem/physiol Actions
2-Amino-3-benzyloxypyridine is an inhibitor of mitogen-activated protein kinase p38α activity.
Synthesis
16867-03-1
100-44-7
24016-03-3
At a temperature lower than 40°C, 48L of deionized water was added to a 300L stainless steel reactor, and 48kg of sodium hydroxide was added under slow stirring until completely dissolved. Subsequently, 16 kg of 2-amino-3-hydroxypyridine, 1.6 kg of tetrabutylammonium bromide, and 17.92 L of benzyl chloride were added sequentially to the sodium hydroxide solution. The reaction mixture was heated to 70~75°C and kept at this temperature for 6 hours. When the reaction was completed, stirring was stopped and the mixture was left to stratify. The aqueous phase was extracted with toluene (20L x 3) and the combined organic phases were washed with pure water (30L x 2). The organic phase was concentrated until a large amount of solid precipitated, followed by crystallization at 0~5°C and stirring for 2 hours. Upon completion of crystallization, centrifugation was performed and the filter cake was washed with 3.2 L of pre-cooled toluene. Finally, it was dried under vacuum at 50~55°C for 3 h to give 22.5 kg of bright yellow solid Intermediate II (2-amino-3-benzyloxypyridine) in 77.3% molar yield and 99.53% purity.
References
[1] Chemistry Letters, 2006, vol. 35, # 3, p. 270 - 271
[2] Synthesis, 1981, # 12, p. 971 - 973
[3] Patent: CN107311998, 2017, A. Location in patent: Paragraph 0035-0036
[4] Journal of Chemical Research, Miniprint, 1986, # 11, p. 3368 - 3390
[5] Patent: CN103570683, 2018, B. Location in patent: Paragraph 0927; 0928; 0930; 0931
2-Amino-3-benzyloxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-3-benzyloxypyridine Suppliers
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View Lastest Price from 2-Amino-3-benzyloxypyridine manufacturers
- Product
- 2-Amino-3-benzyloxypyridine 24016-03-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 2-Amino-3-benzyloxypyridine 24016-03-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-01
- Product
- 2-Amino-3-benzyloxypyridine 24016-03-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08