2-Bromo-4-nitroanisole
- Product Name
- 2-Bromo-4-nitroanisole
- CAS No.
- 5197-28-4
- Chemical Name
- 2-Bromo-4-nitroanisole
- Synonyms
- 2-BROMO-4-NITROANISOLE;anisole, 2-bromo-4-nitro-;2-Bromo-4-nitroanisole >2-BROMO-4-NITROANISOLE 95%;3-BROMO-4-METHOXYNITROBENZENE;1-Methoxy-2-bromo-4-nitrobenzene;Benzene,2-broMo-1-Methoxy-4-nitro-;2-Bromo-1-methoxy-4-nitrobenzene, 2-Bromo-4-nitrophenyl methyl ether
- CBNumber
- CB3706521
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 5197-28-4.mol
2-Bromo-4-nitroanisole Property
- Melting point:
- 104-106 °C (lit.)
- Boiling point:
- 306.3±22.0 °C(Predicted)
- Density
- 1.640±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Brown
- BRN
- 2556372
- CAS DataBase Reference
- 5197-28-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 565407
- Product name
- 2-Bromo-4-nitroanisole
- Purity
- 97%
- Packaging
- 5g
- Price
- $25
- Updated
- 2023/06/20
- Product number
- B2830
- Product name
- 2-Bromo-4-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- B2830
- Product name
- 2-Bromo-4-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $413
- Updated
- 2025/07/31
- Product number
- B688113
- Product name
- 2-Bromo-4-nitroanisole
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB64626
- Product name
- 2-Bromo-4-nitroanisole
- Packaging
- 25g
- Price
- $65
- Updated
- 2021/12/16
2-Bromo-4-nitroanisole Chemical Properties,Usage,Production
Uses
2-Bromo-4-nitroanisole is mainly used as an organic synthetic raw material or intermediate compound. It can be used to prepare 3-Bromo-4-methoxyaniline and its derivatives.
Synthesis
100-17-4
5197-28-4
The general procedure for the synthesis of 2-bromo-4-nitroanisole from 4-nitroanisole was as follows: 1-methoxy-3,5-dimethylbenzene (100 mg, 0.73 mmol), N-bromosuccinimide (NBS, 260 mg, 1.46 mmol), and a stainless steel ball (5 mm in diameter) were placed in a 10 mL stainless steel grinding jar. The ball milling reaction was carried out and the reaction process was monitored by thin layer chromatography (TLC) and proton nuclear magnetic resonance (1H NMR). Upon completion of the reaction, the reaction mixture was transferred to 30 mL of ethyl acetate and cooled at 0°C. The filtrate containing the product and the spent succinimide precipitate were separated by filtration through filter paper. The filtrate was concentrated under vacuum to give 250 mg (yield: 85%) of 2-bromo-4-nitroanisole as a colorless powder. To assess the efficiency of the large-scale synthesis, another monobromination reaction was carried out with 1.3 g of 1-methoxy-3,5-dimethylbenzene for 1 h. The product was isolated in 87% yield. During the reaction, the ball milling equipment was suspended and a small amount of sample was removed from the reaction tank for TLC and 1H NMR analysis, after which the reaction was continued, and the time of this operation was not included in the total reaction time.
References
[1] Tetrahedron Letters, 2015, vol. 55, # 13, p. 2154 - 2156
[2] Tetrahedron Letters, 2014, vol. 55, # 13, p. 2154 - 2156
[3] Applied Catalysis A: General, 2010, vol. 384, # 1-2, p. 18 - 26
[4] International Journal of Chemical Kinetics, 2016, vol. 48, # 2, p. 98 - 105
[5] Journal of the Indian Chemical Society, 1983, vol. 60, p. 953 - 957
2-Bromo-4-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4-nitroanisole Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
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- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
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- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
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View Lastest Price from 2-Bromo-4-nitroanisole manufacturers
- Product
- 2-Bromo-4-nitroanisole 5197-28-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
- Product
- 2-Bromo-4-nitroanisole 5197-28-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02