KYNURENIC ACID

Product Name: KYNURENIC ACID
CAS No.: 492-27-3
Chemical Name: KYNURENIC ACID
Synonyms: NSC 58973;AKOS 235-06;KYNURENIC ACID;Quinurenic acid.;TIMTEC-BB SBB003671;KYNURENIC ACID PURE;2H5]-Kynurenic acid;4-HYDROXYQUINALDIC ACID;KynurenicAcidHydrate>Difelikefalin Impurity 9
CBNumber: CB3711231
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 492-27-3.mol

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KYNURENIC ACID Property

Melting point:: 275 °C (dec.)(lit.)
Boiling point:: 324.41°C (rough estimate)
Density: 1.3175 (rough estimate)
refractive index: 1.5400 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : 9 mg/mL (47.58 mM; Need ultrasonic and warming)
form: Off-white to tan powder.
pka: 1.08±0.30(Predicted)
color: White to Gray to Brown
Water Solubility: 8.92g/L(100 ºC)
Merck: 14,5327
BRN: 147451
CAS DataBase Reference: 492-27-3(CAS DataBase Reference)
EPA Substance Registry System: 2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: UZ9300000
HS Code: 2933.49.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K3375
Product name: Kynurenic acid
Purity: ≥98%
Packaging: 250mg
Price: $20.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: K3375
Product name: Kynurenic acid
Purity: ≥98%
Packaging: 5g
Price: $163
Updated: 2024/03/01

TCI Chemical

Product number: H0303
Product name: Kynurenic Acid Hydrate
Purity: >98.0%(T)(HPLC)
Packaging: 1g
Price: $52
Updated: 2023/06/20

TCI Chemical

Product number: H0303
Product name: Kynurenic Acid Hydrate
Purity: >98.0%(T)(HPLC)
Packaging: 5g
Price: $140
Updated: 2023/06/20

Sigma-Aldrich

Product number: K3375
Product name: Kynurenic acid
Purity: ≥98%
Packaging: 1g
Price: $47.1
Updated: 2024/03/01

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KYNURENIC ACID Chemical Properties,Usage,Production

Uses

An antagonist of NMDA and AMPA/kainate receptors

Uses

Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.

Uses

A product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.

Definition

ChEBI: Kynurenic acid is a quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. It has a role as a G-protein-coupled receptor agonist, a NMDA receptor antagonist, a nicotinic antagonist, a neuroprotective agent, a human metabolite and a Saccharomyces cerevisiae metabolite. It is a monohydroxyquinoline and a quinolinemonocarboxylic acid. It is a conjugate acid of a kynurenate.

Biological Activity

Broad spectrum EAA antagonist.

Biochem/physiol Actions

Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.

storage

Room temperature

Purification Methods

Crystallise the acid from absolute EtOH. The methyl ester crystallises from MeOH with m 224-226o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p2723 1961, Beilstein 22 II 174, 22 III/IV 2245, 22/6 V 280.]

KYNURENIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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KYNURENIC ACID Suppliers

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View Lastest Price from KYNURENIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: KYNURENIC ACID 492-27-3
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 700KG
Release date: 2024-07-16

492-27-3, KYNURENIC ACIDRelated Search:

METHYL 6-BROMO-4-HYDROXYQUINOLINE-2-CARBOXYLATE KYNURENIC ACID KETAMINE RELATED COMPOUND A (50 MG) (1 -[(2-CHLOROPHENYL)(METHYLIMINO)METHYL]CYLCOPENTA-NOL) Ketamine hydrochloride XANTHURENIC ACID 4-METHOXY-2-QUINOLINECARBOXYLIC ACID METHYL 6,8-DIFLUORO-4-HYDROXYQUINOLINE-2-CARBOXYLATE ETHYL 4-HYDROXY-2-QUINOLINECARBOXYLATE Isoconazole nitrate KETAMINE IMPURITY A (S)-(+)-Ketamine hydrochloride KETAMINE HYDROCHLORIDE - REFERENCE SPECTRUM KETAMINE/ZYLAZINE SOLUTION--SCHEDULE*III ITEM 4-Hydroxyquinoline 4-HYDROXYQUINOLINE KYNURENIC-3,5,6,7,8-D5 ACID xanthurenic acid 8-methyl ether 4-Hydroxy-7-methoxy-quinoline-2-carboxylic acid methyl ester

KYNURENIC ACID

2-Carboxy-4-hydroxyquinoline

4-Hydroxyquinaldinic Acid

NSC 58973

4-Hydroxyquinaldic Acid 4-Hydroxyquinoline-2-carboxylic Acid

4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID FOR

4-keto-1H-quinoline-2-carboxylic acid

4-oxo-1H-quinoline-2-carboxylic acid

Kynurenic acid,4-Hydroxyquinoline-2-carboxylic acid

AKOS 235-06

4-HYDROXQUINOLINE-2-CARBOXYLIC ACID

4-HYDROXYQUINALDIC ACID

4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID

TIMTEC-BB SBB003671

4-Hydroxyquinaldic Acid Hydrate

4-Hydroxy-2-quinolincarboxylicacid

4-hydroxy-2-Quinolinecarboxylic acid

Quinurenic acid.

2-Quinolinecarboxylic acid, 4-hydroxy-

KYNURENIC ACID PURE

4-oxido-2-quinolinecarboxylate

KynurenicAcidHydrate&gt

4-Hydroxyquinoline-2-carboxylicacid98%

2H5]-Kynurenic acid

Fibrostop 2|||Quinurenic acid

Difelikefalin Impurity 9

Kynurenic acid (DMSO Solution)

Kynurenic acid, endogenous ionotropic / nicotinic antagonist

492-27-3

492-22-3

HOC9H5NCOOH

C9H5NOHCOOH

Heterocyclic Building Blocks

Ionotropic Glutamate Receptor Modulators

Ion Channels

Ligand-Gated Ion Channels

Hydroxyquinolines

Quinolines

Cell Signaling and Neuroscience

Cell Biology

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Amino Acids & Derivatives, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals

Glutamate

Amino Acids & Derivatives

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Quinolines, Quinazolines and derivatives

Quinoline&Isoquinoline

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