ChemicalBook > CAS DataBase List > (R)-(-)-2-Chloromandelic acid

(R)-(-)-2-Chloromandelic acid

Product Name
(R)-(-)-2-Chloromandelic acid
CAS No.
52950-18-2
Chemical Name
(R)-(-)-2-Chloromandelic acid
Synonyms
(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid;(R)-2-CHLOROMANDELIC ACID;L-2-Chloromandelic;R-Chloromadelic acid;(R)-(-)-2-Chloromand;(R-chloromandelicacid);2-CHLORO-D-MANDELIC ACID;(R)-(-)-2-Chloromandelic;(-)-2-Chloromandelic acid;2-CHLORO-MANDELIC ACID (R)
CBNumber
CB3715688
Molecular Formula
C8H7ClO3
Formula Weight
186.59
MOL File
52950-18-2.mol
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(R)-(-)-2-Chloromandelic acid Property

Melting point:
119-121 °C(lit.)
alpha 
-125 º (c=3, H2O)
Boiling point:
266.91°C (rough estimate)
Density 
1.48
vapor pressure 
0Pa at 25℃
refractive index 
-124.5 ° (C=3, H2O)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Methanol
pka
3.30±0.10(Predicted)
form 
Solid
color 
Off-White
optical activity
[α]23/D 126°, c = 3 in H2O
BRN 
2693370
LogP
1.51 at 23℃
Surface tension
48.7mN/m at 1g/L and 20℃
CAS DataBase Reference
52950-18-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-43-41
Safety Statements 
37/39-26-24/25-36-36/37/39
WGK Germany 
3
HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
727067
Product name
(R)-(?)-2-Chloromandelic acid
Purity
ChiPros
Packaging
5g
Price
$76
Updated
2023/06/20
Sigma-Aldrich
Product number
478873
Product name
(R)-(?)-2-Chloromandelic acid
Purity
99%
Packaging
500mg
Price
$154
Updated
2023/06/20
TCI Chemical
Product number
C1663
Product name
2-Chloro-D-mandelic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
C1663
Product name
2-Chloro-D-mandelic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$59
Updated
2025/07/31
Sigma-Aldrich
Product number
727067
Product name
(R)-(?)-2-Chloromandelic acid
Purity
ChiPros
Packaging
25g
Price
$263
Updated
2024/03/01
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(R)-(-)-2-Chloromandelic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

Clopidogrel intermediate.

Synthesis

74-90-8

89-98-5

10421-85-9

52923-20-3

First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under constant stirring, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex of Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The resulting dark green homogeneous solution was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) to be 98% and the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%.

References

[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[2] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[4] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[5] Patent: US2004/236129, 2004, A1. Location in patent: Page 4

(R)-(-)-2-Chloromandelic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-2-Chloromandelic acid Suppliers

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View Lastest Price from (R)-(-)-2-Chloromandelic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(R)-(-)-2-Chloromandelic acid 52950-18-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500kg
Release date
2021-11-03
Hebei Chuanghai Biotechnology Co., Ltd
Product
(R)-(-)-2-Chloromandelic acid 52950-18-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Henan Aochuang Chemical Co.,Ltd.
Product
(R)-(-)-2-Chloromandelic acid 52950-18-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14

52950-18-2, (R)-(-)-2-Chloromandelic acidRelated Search:

(S)-(+)-Mandelic acid Folic acid Ethyl 2-(Chlorosulfonyl)acetate 2-Chlorobenzyl chloride (S)-Amlodipine 2-Chloroaniline 2-Methylbenzyl chloride Mandelic acid alpha-Chloro-o-fluorotoluene Levetiracetam L-Menthol PALMITOLEIC ACID Citric acid Ascoric Acid P-CHLOROMANDELIC ACID,4-Chloromandelic acid,D/L-4'-CHLOROMANDELIC ACID,4-Chloromandelic acid, Pract. 2-Aminobenzylchloride o-chloromandelic acid,DL-2-CHLOROMANDELIC ACID,2-CHLOROMANDELIC ACID (R)-(-)-3-CHLOROMANDELIC ACID,(R)-3-CHLOROMANDELIC ACID

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  • (2R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
  • (R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
  • (R)-2-Hydroxy-2-(2-chlorophenyl)acetic acid
  • (R)-α-Hydroxy-2-chlorobenzeneacetic acid
  • [R,(-)]-o-Chloro-α-hydroxybenzeneacetic acid
  • (r)-2-chloro-à-hydroxyphenylacetic acid
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  • Benzeneacetic acid, 2-chloro-.alpha.-hydroxy-, (.alpha.R)-
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  • R-(-)-2-Chloromandelic acid ,98%
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  • 2-Chloro-D-mandelic Acid &gt
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  • (R)-(-)-2-ChloroMandelic acidr
  • TIANFU-CHEM (R)-(-)-2-Chloromandelic acid
  • R(-) -o-chlormandelic acid
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  • (-)-2-Chloromandelic acid
  • R (-) - o-chloromandelic acid
  • R-(-)-chloro phenyl glycollic acid
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  • (<i>R</i>)-(?)-2-Chloromandelic acid
  • (R)-2-Chloro-2-phenylglycolicacid
  • 52950-18-2
  • C8H7ClO3
  • Organic Building Blocks
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Carboxylic Acids
  • FINE Chemical & INTERMEDIATES
  • Carboxylic Acids
  • Chiral Building Blocks
  • Organic Building Blocks
  • chiral
  • API intermediates