ChemicalBook > CAS DataBase List > IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

Product Name: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
CAS No.: 78162-58-0
Chemical Name: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
Synonyms: Dexmedetomidine Impurity 27;1-(DIMETHYLSULFAMOYL)IMIDAZOLE;1-(Dimethylsulfamoyl)-1H-imidazole;N,N-dimethylimidazol-1-sulfonamide;1-(Dimethylsulphamoyl)-1H-imidazole;N,N-DIMETHYL IMIDAZOLE-1-SULFONAMIDE;1-(N,N-Dimethylsulfamoyl)-1H-imidazole;N,N-Dimethyl-1H-imidazol-1-sulfonamide;N,N-Dimethyl-1H-imidazole-1-sulfonamide;Imidazole-1-sulfonic acid dimethylamide
CBNumber: CB3720727
Molecular Formula: C5H9N3O2S
Formula Weight: 175.21
MOL File: 78162-58-0.mol

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IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Property

Melting point:: 48-51 °C (lit.)
Boiling point:: 83-87 °C(Press: 0.6 Torr)
Density: 1.35±0.1 g/cm3(Predicted)
Flash point:: 230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 2.41±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C5H9N3O2S/c1-7(2)11(9,10)8-4-3-6-5-8/h3-5H,1-2H3
InChIKey: YRRWNBMOJMMXQY-UHFFFAOYSA-N
SMILES: C1N(S(N(C)C)(=O)=O)C=CN=1
CAS DataBase Reference: 78162-58-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 524883
Product name: 1-(Dimethylsulfamoyl)imidazole
Purity: 97%
Packaging: 5g
Price: $68
Updated: 2023/06/20

TCI Chemical

Product number: D5437
Product name: N,N-Dimethyl-1H-imidazole-1-sulfonamide
Purity: >98.0%(GC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: D5437
Product name: N,N-Dimethyl-1H-imidazole-1-sulfonamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $112
Updated: 2025/07/31

TRC

Product number: D479315
Product name: 1-(N,N-Dimethylsulfamoyl)-1H-imidazole
Packaging: 25g
Price: $495
Updated: 2021/12/16

TRC

Product number: D479315
Product name: 1-(N,N-Dimethylsulfamoyl)-1H-imidazole
Packaging: 5G
Price: $170
Updated: 2021/12/16

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IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Chemical Properties,Usage,Production

Chemical Properties

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is Yellow Semi-Solid

Uses

1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.

Uses

1-(Dimethylsulfamoyl)imidazole may be used to synthesize 1-(dimethylsulfamoyl)-2-imidazolecarboxaldehyde.

Uses

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 r eceptor.

General Description

1-(Dimethylsulfamoyl)imidazole is an imidazole derivative.

Synthesis

288-32-4

13360-57-1

78162-58-0

The general procedure for the synthesis of N,N-dimethylimidazole-1-sulfonamide from imidazole and N,N-dimethylaminosulfonyl chloride is as follows: with reference to Example 7-1 N,N-dimethyl-1H-imidazole-1-sulfonamide, imidazole (5.00 g, 73.6 mmol) was dissolved in toluene (80 ml), followed by the addition of triethylamine (9.52 ml, 68.4 mmol) and N,N-dimethylaminosulfonyl chloride (6.77 ml, 63.3 mmol). The reaction mixture was stirred at room temperature for 8 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to azeotropic distillation with hexane to give the final N,N-dimethylimidazole-1-sulfonamide (10.9 g, 98% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz) with δ-values of 7.87 (s, 1H), 7.23 (d, 1H, J = 1.4 Hz), 7.11 (d, 1H, J = 1.4 Hz), 2.82 (s, 6H).

References

[1] Patent: EP1647546, 2006, A1. Location in patent: Page/Page column 30
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 3, p. 481 - 486
[3] Organic Letters, 2005, vol. 7, # 5, p. 929 - 931
[4] Tetrahedron, 2007, vol. 63, # 4, p. 947 - 952
[5] Journal of the Iranian Chemical Society, 2012, vol. 9, # 6, p. 951 - 955

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%
Supply Ability: 2000
Release date: 2025-08-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Changzhou waston chemical technology Co.,Ltd

Product: IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 97%
Supply Ability: As your request
Release date: 2025-03-19

78162-58-0, IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINERelated Search:

4-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole monohydrochloride 1-(2,3-DiMethylphenyl)-1-(1H-iMidazol-4-yl)ethanol 2,3-DIMETHYLACETOPHENONE Medetomidine Impurity 3 α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol 3,4-Dimethylbromobenzene 2,3-Dimethylbenzyl chloride Dexmedetomidine-025 2,3-Dimethylbenzaldehyde 1-(2,3-Dimethylphenyl)ethyl chloride Demiditraz racemate 2-(2,3-DIMETHYLPHENYL)ETHANOL (2,3-Dimethylphenyl)[1-(trityl)-1H-imidazol-4-yl]methanone Medetomidine Impurity 14 Dexmedetomidine-018 1H-Imidazole, 5-(1-phenylethyl)- Dexmedetomidine-007 Medetomidine Impurity 2

N,N-DIMETHYL IMIDAZOLE-1-SULFONAMIDE

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE

N,N-Dimethyl-1H-imidazole-1-sulphonamide

1-(DIMETHYLSULFAMOYL)IMIDAZOLE

1-(Dimethylsulphamoyl)-1H-imidazole, 1-[(Dimethylamino)sulphonyl]-1H-imidazole

1-(N,N-Dimethylsulfamoyl)-1H-imidazole

1H-IMidazole-1-sulfonaMide,N,N-diMethyl-

1-(Dimethylsulfamoyl)imidazole N,N-Dimethyl-1H-imidazole-1-sulphonamide

N,N-Dimethyl-1H-imidazole-1-sulfonamide

1-(Dimethylsulphamoyl)-1H-imidazole

Dexmedetomidine Impurity 27

N-(1-imidazolyl)-N-methylmethanesulfonamide

1-(Dimethylsulfamoyl)-1H-imidazole

IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE USP/EP/BP

Imidazole-1-sulfonic acid dimethylamide

N,N-Dimethyl-1H-imidazole-1-sulfonamide?New

N,N-Dimethyl-1H-imidazol-1-sulfonamide

N,N-dimethylimidazol-1-sulfonamide

78162-58-0

Heterocyclic Building Blocks

Imidazoles

Building Blocks

Heterocyclic Building Blocks

Sulfonamides

Heterocyclic Compounds

blocks

Imidazoles