IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
- Product Name
- IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
- CAS No.
- 78162-58-0
- Chemical Name
- IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE
- Synonyms
- Dexmedetomidine Impurity 27;1-(DIMETHYLSULFAMOYL)IMIDAZOLE;1-(Dimethylsulfamoyl)-1H-imidazole;N,N-dimethylimidazol-1-sulfonamide;1-(Dimethylsulphamoyl)-1H-imidazole;N,N-DIMETHYL IMIDAZOLE-1-SULFONAMIDE;1-(N,N-Dimethylsulfamoyl)-1H-imidazole;N,N-Dimethyl-1H-imidazol-1-sulfonamide;N,N-Dimethyl-1H-imidazole-1-sulfonamide;Imidazole-1-sulfonic acid dimethylamide
- CBNumber
- CB3720727
- Molecular Formula
- C5H9N3O2S
- Formula Weight
- 175.21
- MOL File
- 78162-58-0.mol
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Property
- Melting point:
- 48-51 °C (lit.)
- Boiling point:
- 83-87 °C(Press: 0.6 Torr)
- Density
- 1.35±0.1 g/cm3(Predicted)
- Flash point:
- 230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 2.41±0.10(Predicted)
- color
- Pale Yellow
- InChI
- InChI=1S/C5H9N3O2S/c1-7(2)11(9,10)8-4-3-6-5-8/h3-5H,1-2H3
- InChIKey
- YRRWNBMOJMMXQY-UHFFFAOYSA-N
- SMILES
- C1N(S(N(C)C)(=O)=O)C=CN=1
- CAS DataBase Reference
- 78162-58-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 524883
- Product name
- 1-(Dimethylsulfamoyl)imidazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $68
- Updated
- 2023/06/20
- Product number
- D5437
- Product name
- N,N-Dimethyl-1H-imidazole-1-sulfonamide
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- D5437
- Product name
- N,N-Dimethyl-1H-imidazole-1-sulfonamide
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- D479315
- Product name
- 1-(N,N-Dimethylsulfamoyl)-1H-imidazole
- Packaging
- 5G
- Price
- $170
- Updated
- 2021/12/16
- Product number
- D479315
- Product name
- 1-(N,N-Dimethylsulfamoyl)-1H-imidazole
- Packaging
- 25g
- Price
- $495
- Updated
- 2021/12/16
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Chemical Properties,Usage,Production
Chemical Properties
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is Yellow Semi-Solid
Uses
1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.
Uses
1-(Dimethylsulfamoyl)imidazole may be used to synthesize 1-(dimethylsulfamoyl)-2-imidazolecarboxaldehyde.
Uses
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 r eceptor.
General Description
1-(Dimethylsulfamoyl)imidazole is an imidazole derivative.
Synthesis
288-32-4
13360-57-1
78162-58-0
The general procedure for the synthesis of N,N-dimethylimidazole-1-sulfonamide from imidazole and N,N-dimethylaminosulfonyl chloride is as follows: with reference to Example 7-1 N,N-dimethyl-1H-imidazole-1-sulfonamide, imidazole (5.00 g, 73.6 mmol) was dissolved in toluene (80 ml), followed by the addition of triethylamine (9.52 ml, 68.4 mmol) and N,N-dimethylaminosulfonyl chloride (6.77 ml, 63.3 mmol). The reaction mixture was stirred at room temperature for 8 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to azeotropic distillation with hexane to give the final N,N-dimethylimidazole-1-sulfonamide (10.9 g, 98% yield). The product was characterized by 1H NMR (CDCl3, 400 MHz) with δ-values of 7.87 (s, 1H), 7.23 (d, 1H, J = 1.4 Hz), 7.11 (d, 1H, J = 1.4 Hz), 2.82 (s, 6H).
References
[1] Patent: EP1647546, 2006, A1. Location in patent: Page/Page column 30
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984, # 3, p. 481 - 486
[3] Organic Letters, 2005, vol. 7, # 5, p. 929 - 931
[4] Tetrahedron, 2007, vol. 63, # 4, p. 947 - 952
[5] Journal of the Iranian Chemical Society, 2012, vol. 9, # 6, p. 951 - 955
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE Suppliers
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- akos@akosgmbh.eu
- Country
- Germany
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- 1061
- Advantage
- 60
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- info@abcr.de
- Country
- Germany
- ProdList
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View Lastest Price from IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE manufacturers
- Product
- IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 95%
- Supply Ability
- 2000
- Release date
- 2025-08-29
- Product
- IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- IMIDAZOLE-1-SULFONIC ACID DIMETHYL AMINE 78162-58-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 97%
- Supply Ability
- As your request
- Release date
- 2025-03-19