BW B70C
- Product Name
- BW B70C
- CAS No.
- 134470-38-5
- Chemical Name
- BW B70C
- Synonyms
- 70c;BW B70C;N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure;Urea, N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy-;(e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure
- CBNumber
- CB3730205
- Molecular Formula
- C17H17FN2O3
- Formula Weight
- 316.33
- MOL File
- 134470-38-5.mol
BW B70C Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 22 mg/mL, soluble
- form
- solid
- color
- white
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- YT3976666
N-Bromosuccinimide Price
- Product number
- B4558
- Product name
- BW B70C
- Purity
- >98% (HPLC), solid
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 20686
- Product name
- BW B70C
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 20686
- Product name
- BW B70C
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 20686
- Product name
- BW B70C
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 1304
- Product name
- BW B70C
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $140
- Updated
- 2021/12/16
BW B70C Chemical Properties,Usage,Production
Uses
BW B70C is a 5-LO (5-lipoxygenase) inhibitor.
Definition
ChEBI: A hydroxamic acid that is urea in which both the hydrogens attached to one of the nitrogens are replaced by a hydroxy and a (1E)-1-[3-(4-fluorophenoxy)phenyl]but-1-en-3-yl group. A selective inhibitor of arachidonate 5-lipoxygenase, it ca be used for the treatment of asthma.
Biological Activity
A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability.
References
[1]. payne an, jackson wp, salmon ja, et al. hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. agents actions suppl, 1991, 34: 189-199.
[2]. yeadon m, dougan fl, petrovic a, et al. effect of bw b70c, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. agents actions, 1993, 38(1-2): 8-18.
[3]. bureau mf, de castro cm, cortese c, et al. 5-lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. eur j pharmacol, 1997, 324(1): 89-98.
[4]. jatana m, giri s, ansari ma, et al. inhibition of nf-kappab activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. j neuroinflammation, 2006, 3: 12.