ChemicalBook > CAS DataBase List > BW B70C

BW B70C

Product Name
BW B70C
CAS No.
134470-38-5
Chemical Name
BW B70C
Synonyms
70c;BW B70C;N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure;Urea, N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy-;(e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure
CBNumber
CB3730205
Molecular Formula
C17H17FN2O3
Formula Weight
316.33
MOL File
134470-38-5.mol
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BW B70C Property

storage temp. 
2-8°C
solubility 
DMSO: 22 mg/mL, soluble
form 
solid
color 
white
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
YT3976666
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B4558
Product name
BW B70C
Purity
>98% (HPLC), solid
Packaging
10mg
Price
$214
Updated
2024/03/01
Cayman Chemical
Product number
20686
Product name
BW B70C
Purity
≥95%
Packaging
500μg
Price
$24
Updated
2021/12/16
Cayman Chemical
Product number
20686
Product name
BW B70C
Purity
≥95%
Packaging
1mg
Price
$41
Updated
2021/12/16
Cayman Chemical
Product number
20686
Product name
BW B70C
Purity
≥95%
Packaging
5mg
Price
$82
Updated
2021/12/16
Tocris
Product number
1304
Product name
BW B70C
Purity
≥98%(HPLC)
Packaging
10
Price
$140
Updated
2021/12/16
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BW B70C Chemical Properties,Usage,Production

Uses

BW B70C is a 5-LO (5-lipoxygenase) inhibitor.

Definition

ChEBI: A hydroxamic acid that is urea in which both the hydrogens attached to one of the nitrogens are replaced by a hydroxy and a (1E)-1-[3-(4-fluorophenoxy)phenyl]but-1-en-3-yl group. A selective inhibitor of arachidonate 5-lipoxygenase, it ca be used for the treatment of asthma.

Biological Activity

A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability.

References

[1]. payne an, jackson wp, salmon ja, et al. hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. agents actions suppl, 1991, 34: 189-199.
[2]. yeadon m, dougan fl, petrovic a, et al. effect of bw b70c, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. agents actions, 1993, 38(1-2): 8-18.
[3]. bureau mf, de castro cm, cortese c, et al. 5-lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. eur j pharmacol, 1997, 324(1): 89-98.
[4]. jatana m, giri s, ansari ma, et al. inhibition of nf-kappab activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. j neuroinflammation, 2006, 3: 12.

BW B70C Preparation Products And Raw materials

Raw materials

Preparation Products

134470-38-5, BW B70CRelated Search:


  • N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA
  • N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA
  • (e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure
  • 70c
  • n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure
  • BW B70C
  • Urea, N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy-
  • 134470-38-5