2-(4-CHLOROPHENOXY)ANILINE

Product Name: 2-(4-CHLOROPHENOXY)ANILINE
CAS No.: 2770-11-8
Chemical Name: 2-(4-CHLOROPHENOXY)ANILINE
Synonyms: Amoxapine RC 4;Amoxapine Impurity 2;2-(4-CHLOROPHENOXY)ANILINE;2-(4'-CHLOROPHENOXY)ANILINE;2-(4-chlorophenoxy)benzenamine;2-Amino-4'-chlorodiphenyl Ether;[2-(4-chlorophenoxy)phenyl]amine;Benzenamine, 2-(4-chlorophenoxy)-;2-Amino-4'-chlorodiphenyl Ether >2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%
CBNumber: CB3739965
Molecular Formula: C12H10ClNO
Formula Weight: 219.67
MOL File: 2770-11-8.mol

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2-(4-CHLOROPHENOXY)ANILINE Property

Boiling point:: 202°C/15mmHg(lit.)
Density: 1.260±0.06 g/cm3(Predicted)
refractive index: 1.6180-1.6220
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Oil
pka: 3.69±0.10(Predicted)
color: Colourless to Light Orange
CAS DataBase Reference: 2770-11-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2223
Product name: 2-Amino-4'-chlorodiphenyl Ether
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $185
Updated: 2025/07/31

TRC

Product number: C374980
Product name: 2-(4-Chlorophenoxy)aniline
Packaging: 25g
Price: $990
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20307
Product name: 2-(4-Chlorophenoxy)aniline
Packaging: 1g
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: 2657AB
Product name: 2-(4-Chlorophenoxy)aniline
Packaging: 1g
Price: $99
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20307
Product name: 2-(4-Chlorophenoxy)aniline
Packaging: 2g
Price: $130
Updated: 2021/12/16

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2-(4-CHLOROPHENOXY)ANILINE Chemical Properties,Usage,Production

Chemical Properties

pale yellow powder

Uses

Amoxapine impurity.

Synthesis

39145-47-6

2770-11-8

General procedure for the synthesis of 4'-chloro-2-amino-diphenyl ether from 1-(4-chlorophenoxy)-2-nitrobenzene: A mixture of commercially available iron powder (3.18 g, 57.28 mmol) and ammonium chloride (383 mg, 7.15 mmol) in ethanol (45 mL) and water (8 mL) was refluxed. To this mixture was added 1-(4-chlorophenoxy)-2-nitrobenzene (AMR01028,2.2 g, 8.81 mmol) and the resulting mixture was stirred at reflux for 1 hour. After completion of the reaction, the solvent was removed and the residue was diluted in aqueous sodium bicarbonate (40 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was evaporated to give 4'-chloro-2-amino-diphenyl ether (AMR01029,1.50 g, 78%) as a colorless oil, which could be used in the next step without further purification. Thin layer chromatography (TLC) Rf value was 0.53 (unfolding agent: dichloromethane).1H NMR (270MHz, CDCl3) data: δ 3.77 (2H, broad single peak, NH2), 6.71 (1H, multiple peaks), 6.83 (2H, multiple peaks), 6.89 (2H, AA'BB' system), 6.99 (1H, multiple peaks), 7.25 ( 2H, AA'BB' system).

References

[1] Patent: WO2007/3934, 2007, A2. Location in patent: Page/Page column 119
[2] Journal of the American Chemical Society, 2014, vol. 136, # 40, p. 14060 - 14067
[3] Journal of the Chemical Society, 1931, p. 529,533
[4] Journal of the Chemical Society, 1925, vol. 127, p. 2011
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976, p. 1279 - 1285

2-(4-CHLOROPHENOXY)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-CHLOROPHENOXY)ANILINE Suppliers

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2770-11-8, 2-(4-CHLOROPHENOXY)ANILINERelated Search:

5-CHLORO-2-(4-CHLOROPHENOXY)ANILINE Loxapine succinate salt 2-(4-CHLOROPHENOXY)ANILINE 4-(4-CHLORO-3-METHYLPHENOXY)-3-NITROBENZOTRIFLUORIDE 2-(2,4-DICHLOROPHENOXY)ANILINE HYDROCHLORIDE 5-chloro-2-(2,4-dichlorophenoxy)aniline 2-(2,4-Dichlorophenoxy)aniline 1-[(4-Chlorophenyl)oxy]-2-nitrobenzene 4-Chloro-1-(4-chlorophenoxy)-2-nitrobenzene 2,4-DICHLORO-4'-AMINODIPHENYL ETHER 4-Amino-4'-chlorodiphenyl ether 2-(2-CHLOROPHENOXY)ANILINE 5-Chloro-2-(2-chlorophenoxy)aniline 2-(3-CHLOROPHENOXY)ANILINE 3-CHLORO-2-(3-CHLOROPHENOXY)ANILINE 4-Chlorodiphenyl ether Aniline 2-AMINO-4'-CHLORO-4-TRIFLUOROMETHYL DIPHENYL ETHER

2-(4'-CHLOROPHENOXY)ANILINE

2-(4-CHLOROPHENOXY)ANILINE

2-(4-chlorophenoxy)benzenamine

[2-(4-chlorophenoxy)phenyl]amine

2-Amino-4'-chlorodiphenyl Ether &gt

Amoxapine Impurity 2

Benzenamine, 2-(4-chlorophenoxy)-

Amoxapine RC 4

2-Amino-4'-chlorodiphenyl Ether, ≥ 98.0%

2-Amino-4'-chlorodiphenyl Ether

2770-11-8

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Intermediates

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