ChemicalBook > CAS DataBase List > 2,5-DIMETHOXYBENZONITRILE

2,5-DIMETHOXYBENZONITRILE

Product Name
2,5-DIMETHOXYBENZONITRILE
CAS No.
5312-97-0
Chemical Name
2,5-DIMETHOXYBENZONITRILE
Synonyms
Einecs 226-169-2;2,5-DIMETHOXYBENZONI;2,5-DIMETHOXYBENZONITRILE;Benzonitrile, 2,5-dimethoxy-;2,5-Dimethoxybenzonitrile>2-cyanohydroquinone dimethyl ether
CBNumber
CB3740819
Molecular Formula
C9H9NO2
Formula Weight
163.17
MOL File
5312-97-0.mol
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2,5-DIMETHOXYBENZONITRILE Property

Melting point:
81-85 °C (lit.)
Boiling point:
288.8±25.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Yellow to Orange
BRN 
2691937
CAS DataBase Reference
5312-97-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
RIDADR 
3276
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
594776
Product name
2,5-Dimethoxybenzonitrile
Purity
97%
Packaging
5g
Price
$224
Updated
2023/06/20
TCI Chemical
Product number
D3659
Product name
2,5-Dimethoxybenzonitrile
Purity
>98.0%(GC)
Packaging
1g
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
D3659
Product name
2,5-Dimethoxybenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$70
Updated
2025/07/31
TRC
Product number
D525963
Product name
2,5-Dimethoxybenzonitrile
Packaging
250mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD64139
Product name
2,5-Dimethoxybenzonitrile
Packaging
2g
Price
$50
Updated
2021/12/16
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2,5-DIMETHOXYBENZONITRILE Chemical Properties,Usage,Production

Synthesis

68-12-2

150-78-7

5312-97-0

At 0 °C, n-butyllithium (1.67 M hexane solution, 2.9 mL, 4.8 mmol) was slowly added dropwise to a solution of 1,3-dimethoxybenzene (0.55 g, 4.0 mmol) in tetrahydrofuran (5 mL). The reaction mixture was stirred continuously at 0 °C for 2 hours. Subsequently, N,N-dimethylformamide (0.34 mL, 4.4 mmol) was added to the mixture and stirring was continued for 2 hours at 0 °C. Upon completion of the reaction, ammonia solution (8 mL, 120 mmol) and iodine (1.12 g, 4.4 mmol) were added and the mixture was transferred to room temperature and stirred for 2 hours. The reaction mixture was quenched with saturated aqueous sodium sulfite solution (15 mL) and extracted several times with ether (3 x 20 mL). The organic layers were combined, washed with saturated saline and dried over anhydrous sodium sulfate to give the crude product 2,6-dimethoxybenzonitrile with a purity of over 80%. The crude product was purified by silica gel short-column chromatography (eluent: hexane/ethyl acetate=3:1) to afford pure 2,6-dimethoxybenzonitrile as a colorless solid in 91% yield.

References

[1] Synlett, 2010, # 10, p. 1562 - 1566
[2] Tetrahedron, 2011, vol. 67, # 5, p. 958 - 964

2,5-DIMETHOXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,5-DIMETHOXYBENZONITRILE Suppliers

Americas 1 China 83 Europe 1 France 1 Germany 3 India 3 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 12 United States 20 Global 128
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View Lastest Price from 2,5-DIMETHOXYBENZONITRILE manufacturers

Career Henan Chemical Co
Product
2,5-DIMETHOXYBENZONITRILE 5312-97-0
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

5312-97-0, 2,5-DIMETHOXYBENZONITRILERelated Search:

3,2-DIMETHOXYBENZONITRILE,2,3-DIMETHOXYBENZONITRILE 2,5-DIMETHOXYBENZONITRILE 2,6-DIMETHOXYBENZONITRILE 2,3-DIMETHOXYBENZONITRILE 2-BROMO-4,5-DIMETHOXY-BENZONITRILE 1,4-DIACETOXY-2,3-DICYANOBENZENE 2-METHOXY-5-TRIFLUOROMETHOXY-BENZONITRILE 2-CHLORO-3,4-DIMETHOXYBENZONITRILE 3-BROMO-4,5-DIMETHOXY-BENZONITRILE 2-FLUORO-6-DIMETHOXYBENZONITRILE 2,4-DIMETHOXYBENZONITRILE 2-AMINO-4,5-DIMETHOXYBENZONITRILE,2-AMINO-4,5-DIMETHOXYBENZONITRILE TECHN. 95%,2-AMINO-4 5-DIMETHOXYBENZONITRILE 96% 3,5-DIMETHOXYBENZONITRILE / 3,5-DIMETHOXYLPHENYL CYANIDE,3,5-DIMETHOXYBENZONITRILE 1 4-DIBUTOXY-2 3-NAPHTHALENEDI- 2,4,5-TRIMETHOXYBENZONITRILE 2,5-dimethoxy-4-nitrobenzonitrile 4-amino-2,6-dimethoxybenzonitrile 3 6-DIBUTOXY-1 2-BENZENEDICARBONITRILE

  • 2,5-DIMETHOXYBENZONITRILE
  • 2-cyanohydroquinone dimethyl ether
  • Einecs 226-169-2
  • 2,5-DIMETHOXYBENZONI
  • 2,5-Dimethoxybenzonitrile&gt
  • Benzonitrile, 2,5-dimethoxy-
  • 5312-97-0
  • Nitrogen Compounds
  • Organic Building Blocks
  • Cyanides/Nitriles
  • Building Blocks
  • C8 to C9
  • Aromatic Nitriles
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Nitriles
  • C8 to C9
  • Cyanides/Nitriles
  • Nitrogen Compounds