ChemicalBook > CAS DataBase List > BAFILOMYCIN A1

BAFILOMYCIN A1

Product Name
BAFILOMYCIN A1
CAS No.
88899-55-2
Chemical Name
BAFILOMYCIN A1
Synonyms
CS-1163;afilomycin A1;BAFILOMYCIN A1;BAFILOMYCIN A1 95%;Bafilomycin A1,95%;BAFILOMYCIN A1, 98+%;Bafilomycin A1(Baf-A1);BAFILOMYCIN A1 USP/EP/BP;BAFILOMYCIN A1, STREPTOMYCES GRISEUS;BafilomycinA1fromStreptomycesgriseus
CBNumber
CB3743951
Molecular Formula
C35H58O9
Formula Weight
622.83
MOL File
88899-55-2.mol
More
Less

BAFILOMYCIN A1 Property

Melting point:
>106°C (dec.)
Boiling point:
582.86°C (rough estimate)
Density 
1.0594 (rough estimate)
refractive index 
1.5000 (estimate)
RTECS 
RN9781000
Flash point:
87℃
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 5 mg/ml, with warming).
form 
Powder or Solid
pka
12.66±0.70(Predicted)
color 
White to off-white
Water Solubility 
Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
BRN 
4730700
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
3172
WGK Germany 
3
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29419090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B1793
Product name
Bafilomycin A1 from Streptomyces griseus
Purity
≥90% (HPLC)
Packaging
2μg
Price
$86.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1661
Product name
Bafilomycin A1 Ready Made Solution
Purity
0.16?mMinDMSO,fromStreptomycesgriseus
Packaging
0.1ml
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
B1793
Product name
Bafilomycin A1 from Streptomyces griseus
Purity
≥90% (HPLC)
Packaging
10μg
Price
$210
Updated
2024/03/01
Sigma-Aldrich
Product number
196000
Product name
Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
Purity
Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.
Packaging
10μG
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08409
Product name
InSolution Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem
Purity
A 100 μM (15 μg/241 μL) sterile-filtered solution of Bafilomycin A1,
Packaging
15μG
Price
$280
Updated
2024/03/01
More
Less

BAFILOMYCIN A1 Chemical Properties,Usage,Production

Description

Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases; Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A1 (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

Chemical Properties

white to off-white powder

Uses

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Uses

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Uses

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Definition

ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

General Description

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).

Biological Activity

Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.

storage

-20°C

References

1) Werner?et al.? (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot.,?37?110 2) Drose and Altendorf? (1997)?Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase;?J. Exp. Biol.,?200?1 3) Yamamoto?et al. (1998)?Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells;?Cell Struct. Func.,?23?33

BAFILOMYCIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BAFILOMYCIN A1 Suppliers

Australia 2 Belgium 1 China 154 France 1 Germany 4 India 1 Japan 3 Poland 1 South Korea 1 Switzerland 2 United Kingdom 10 United States 33 USA 1 Global 214
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6000
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
LC Laboratories
Tel
--
Fax
--
Email
custserv@lclabs.com
Country
United States
ProdList
503
Advantage
50
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Kainic.com
Tel
--
Fax
--
Email
info@Kainic.com
Country
United States
ProdList
330
Advantage
38
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
A.G. Scientific, Inc.
Tel
--
Fax
--
Email
support@agscientific.com
Country
United States
ProdList
1066
Advantage
71
Upstate
Tel
--
Fax
--
Email
info@upstate.com
Country
United States
ProdList
876
Advantage
76
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77
Kamiya Biomedical Company
Tel
--
Fax
--
Email
ordering@kamiyabiomedical.com
Country
United States
ProdList
736
Advantage
72
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from BAFILOMYCIN A1 manufacturers

Dideu Industries Group Limited
Product
BAFILOMYCIN A1 88899-55-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-16
Career Henan Chemical Co
Product
BAFILOMYCIN A1 88899-55-2
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

88899-55-2, BAFILOMYCIN A1Related Search:

Bufalin Thapsigargin 6-Gingerol OLIGOMYCIN A citreoviridin BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES,bafilomycin b1from streptomyces sp.,BAFILOMYCIN B1 bafilomycin D BAFILOMYCIN C1 BAFILOMYCIN A1 BAFILOMYCIN B2 BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS BAFILOMYCIN B1 MONOHYDRATE Bafilomycin D2' Bafilomycin E Bafilomycin D1 Bafilomycin C2 Bafilomycin A2 BAFILOMYCIN A1 (DRY ICE)

  • Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus
  • Bafilomycin A1(Baf-A1)
  • Bafilomycin A1, 95%, from Streptomyces griseus
  • CS-1163
  • Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
  • BAFILOMYCIN A1
  • BAFILOMYCIN A1, STREPTOMYCES GRISEUS
  • Bafilomycin A1 from Streptomycesgriseus, 10 ug
  • BAFILOMYCIN A1, 98+%
  • BAFILOMYCIN A1 95%
  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5
  • BafilomycinA1fromStreptomycesgriseus
  • 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin
  • Bafilomycin A1,95%
  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
  • (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o
  • Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-
  • BafilomycinBafilomycin A1Bafilomycin A1, from Streptomyces griseus
  • BAFILOMYCIN A1 USP/EP/BP
  • (3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
  • afilomycin A1
  • (3Z,5E,11E,13E)-16-[4-(2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl)-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
  • Bafilomycin A1, (V)-ATPase inhibitor
  • 88899-55-2
  • C35H58O9
  • Antibiotics A-F
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • antibiotic
  • A - KAntibiotics
  • Antibacterial
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Antibiotics by Application
  • AntifungalAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • MacrolidesMore...Close...
  • Mechanism of Action
  • Spectrum of Activity
  • Peptide Synthesis/Antibiotics