2-Chloro-4-methoxypyridine
- Product Name
- 2-Chloro-4-methoxypyridine
- CAS No.
- 17228-69-2
- Chemical Name
- 2-Chloro-4-methoxypyridine
- Synonyms
- IFLAB-BB F1957-0003;2-chloro-Methoxypyridine;2-CHLORO-4-METHOXYPYRIDINE;Pyridine,2-chloro-4-Methoxy-;2-Chloro-4-methoxypyridine>2-Chloro-4-Methoxypyridine 97%;2-Chloro-4-methoxypyridine(RS20006968);JRH-09202, 2-Chloro-4-methoxypyridine, 97%;2-Chloro-4-methoxypyridine ISO 9001：2015 REACH
- CBNumber
- CB3746301
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 17228-69-2.mol
2-Chloro-4-methoxypyridine Property
- Boiling point:
- 224-225 °C (lit.)
- Density
- 1.258 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5400(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in alcohol.
- form
- Liquid
- pka
- 2.25±0.10(Predicted)
- Specific Gravity
- 1.258
- color
- Colorless to pale yellow
- BRN
- 1423379
- InChI
- InChI=1S/C6H6ClNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3
- InChIKey
- PMTPFBWHUOWTNN-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(OC)=C1
- CAS DataBase Reference
- 17228-69-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 557404
- Product name
- 2-Chloro-4-methoxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $87.2
- Updated
- 2023/06/20
- Product number
- C3024
- Product name
- 2-Chloro-4-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- C3024
- Product name
- 2-Chloro-4-methoxypyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $108
- Updated
- 2025/07/31
- Product number
- C381363
- Product name
- 2-Chloro-4-methoxypyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y15202
- Product name
- 2-Chloro-4-methoxypyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-Chloro-4-methoxypyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
It is an active pharmaceutical ingredient.
Uses
2-Chloro-4-methoxypyridine may be used to synthesize:
- 2-(2′,4′-difluorophenyl)-4-methoxypyridine
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol
- (2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate
General Description
2-Chloro-4-methoxypyridine can be obtained from the reaction between 2-chloro-4-nitropyridine and sodium methoxide in the presence of dioxane. It can also be prepared starting from 4-methoxy-2(1H)-pyridone and 4-nitropyridine N-oxide.
Synthesis
At room temperature, 4-tert-butylpyridine (5.5 mL, 5.08 g, 37.5 mmol, Aldrich) was dissolved in acetic acid (30 ) mL, Fluka). Hydrogen peroxide was added (30% aqueous solution, 11.5 mL, containing 3.83 g H2O2, 113 mmol, excess, Fluka.). The reaction mixture was stirred at 80 ??C overnight. It was rotor evaporated to 1/3 of its volume, neutralized with aqueous Na2CO3 and extracted several times with CH2Cl2. The organic layer was evaporated to dryness. The starting material (0.2-1.0% CH3OH in CH2Cl2) was removed and the product (5-7% CH3OH in CH2Cl) was recovered by chromatographic purification (run twice; silica, 2 x 25 g). 2-chloro-4-methoxypyridine. The reaction was carried out in dry DMF under argon. At room temperature, sodium methanol (190) was added to the reaction. mg, 3.52 mmol, excess, Fluka) was added to 2-chloro-4-nitropyridine (500 mg, 3.15 mmol, Aldrich) in DMF immediately undergoes an exothermic reaction and the color of the mixture changes from light yellow to dark red. Stirring for 3 h at room temperature gave a brown suspension which was extracted with water and ether. The organic layer was washed with water to remove the DMF. purification by chromatography (silica, 10 g; CH2Cl2) afforded the colorless oily product 2-chloro-4-methoxypyridine: 393 mg (2.74 mmol, 87%).
2-Chloro-4-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-methoxypyridine manufacturers
- Product
- 2-Chloro-4-methoxypyridine 17228-69-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 2-Chloro-4-methoxypyridine 17228-69-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-30