ChemicalBook > CAS DataBase List > BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

Product Name: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
CAS No.: 18720-35-9
Chemical Name: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
Synonyms: 4- (methoxy carbonyl) double ring [2.2.2] octane -1- carboxylic acid;o[2.2.2]octane-1-carboxyL;l)bicyclo[2.2.2]octane-1-carboxylic acid;4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-;1-Methyl bicyclo[2.2.2]octane-1,4-dicarboxylate;1-Carboxy-4-(Methoxycarbonyl)bicyclo[2.2.2]octane;1-Methyl bicyclo[2.2.2]heptane-1, 4-dicarboxylate;Bicyclo [2.2.2] octane-1,4-cyclohexanedicarboxylate;4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid;4-(METHOXYCARBONYL)BICYCLO[2.2.2]OCTANE-1-CARBOXYLICACID
CBNumber: CB3748693
Molecular Formula: C11H16O4
Formula Weight: 212.24
MOL File: 18720-35-9.mol

Less

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Property

Melting point:: 186.0 to 190.0 °C
Boiling point:: 322.5±42.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystaline
pka: 4.77±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H16O4/c1-15-9(14)11-5-2-10(3-6-11,4-7-11)8(12)13/h2-7H2,1H3,(H,12,13)
InChIKey: KBZVAQVEHVGIEI-UHFFFAOYSA-N
SMILES: C12(C(OC)=O)CCC(C(O)=O)(CC1)CC2

Less

Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2917200090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00226
Product name: 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
Purity: AldrichCPR
Packaging: 1g
Price: $475
Updated: 2025/07/31

TCI Chemical

Product number: M2855
Product name: 4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $81
Updated: 2025/07/31

TRC

Product number: M261285
Product name: 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
Packaging: 10g
Price: $1075
Updated: 2021/12/16

Oakwood

Product number: 334351
Product name: 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Activate Scientific

Product number: AS36904
Product name: 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
Purity: 97+%
Packaging: 1g
Price: $56
Updated: 2021/12/16

Less

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Chemical Properties,Usage,Production

Uses

4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic Acid has been used as a reactant for the preparation of bicyclo-octyltriazole inhibitors of HSD1 for metabolic syndrome treatment.

Synthesis

1459-96-7

18720-35-9

General procedure for the synthesis of 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1,4-dicarboxylic acid from dimethyl bicyclo[2.2.2]octane-1-carboxylate: a mixture of 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid (20 g) and potassium hydroxide (5.5 g) in methanol/water (10:1, 106 mL) was heated to reflux overnight. After the reaction was completed, it was cooled to room temperature and concentrated. The residue was diluted with ethyl acetate and extracted with 1N aqueous sodium hydroxide (2 x 100mL). The organic phase was dried with magnesium sulfate, filtered and concentrated to give the starting material as a white solid. The combined aqueous phases were adjusted to pH 1-2 with 2N aqueous hydrochloric acid and extracted with ethyl acetate (4 x 250mL). The combined turbid organic phases were filtered through a slot filter, washed with saturated aqueous sodium chloride, dried over magnesium sulfate, filtered and concentrated to afford 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid as a colorless solid (13.1 g, 70% yield). Mass spectral analysis showed [MH]+ = 213.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5731 - 5737
[2] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 164-165
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 177-178
[4] Patent: WO2014/159802, 2014, A1. Location in patent: Paragraph 00189
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1558 - 1568

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Suppliers

Americas 1 Belgium 1 Canada 1 China 192 Europe 1 Germany 3 India 4 Japan 3 Spain 1 The Netherlands 1 United Kingdom 6 United States 31 Global 245

Changzhou Langyi Biomedical Technology Co., Ltd.

Tel: 13706129682
Email: tiffany@langyupharm.com
Country: China
ProdList: 84
Advantage: 58

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188 13327728092
Email: sales@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Tianjin Nuokang Pharmaceutical Technology Co., Ltd.

Tel: 022-23989838 13810451150
Email: 44766350@qq.com
Country: China
ProdList: 2349
Advantage: 58

Jinan Junhe Pharmaceutical Co., Ltd

Tel: 13053355392
Email: 1731854553@qq.com
Country: China
ProdList: 211
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ChangShu Haitian Fine Chemicals Co.,Ltd

Tel: 13913622609
Fax: 86-512-52893680
Email: 974295387@qq.com
Country: China
ProdList: 192
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

EnciPharmatech Co., Ltd

Tel: 025-52714267-66 13813902930
Fax: 86 025 52714266
Email: stephen_shengll@hotmail.com
Country: China
ProdList: 232
Advantage: 64

ChangZhou SIDU chemical Co., Ltd.

Tel: 0519-81291281 18015082300
Fax: 0519-81291281
Email: siduchem@hotmail.com
Country: China
ProdList: 274
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Baiyin Chengze Chemical Technology Co., Ltd.

Tel: +86 943-8535351 13389336721
Fax: +86-943-8535351
Email: sales@chengzechem.com
Country: China
ProdList: 289
Advantage: 58

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 17722620669
Fax: 0752-5319394
Email: liangcong.yi@rafflespt.com
Country: China
ProdList: 279
Advantage: 58

shanghai aokchem co., ltd

Tel: 021-68712331 39130253
Fax: 18621350903
Email: aokchem@gmail.com
Country: China
ProdList: 332
Advantage: 58

ShangHai Onsyn-Chemical Technology Co., Ltd.

Tel: 021-58359326 15900795984
Fax: +86-21-58359326
Email: angsihuaxue@126.com
Country: China
ProdList: 252
Advantage: 55

Hebei Summedchem Co.,Ltd

Tel: 0319-5801333-8008 15630992918
Email: sales@summedchem.com
Country: China
ProdList: 965
Advantage: 58

DONGSHENG CHIRAL PHARMA

Tel: 15800326364 18051538752
Email: 582512789@qq.com
Country: China
ProdList: 449
Advantage: 55

YangZhou Ruihong Biotech Co., Ltd.

Tel: 0514-015380367604 15380367604
Fax: 0514-83828236
Email: sales@ruibobiotech.com
Country: China
ProdList: 511
Advantage: 55

Aloespharm Co., Ltd.

Tel: 021-20960837
Fax: 021-20960837
Email: market@aloespharm.com
Country: China
ProdList: 1302
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3852
Advantage: 58

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2789
Advantage: 52

Shanghai Race Chemical Co., Ltd.

Tel: 86-021-54933292
Fax: 86-021-54933292
Email: sales@racechemical.com
Country: China
ProdList: 239
Advantage: 50

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4895
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Suzhou Crst Pharmatech Co., Ltd.

Tel: 0512-62910395 17751098781
Fax: 0512-62910396
Email: sales@crstpharma.com
Country: China
ProdList: 499
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

CHMA Chemical Technology (Shanghai) Co., Ltd

Tel: 021-61556450 15800904410
Fax: 021-61556450
Country: China
ProdList: 2832
Advantage: 58

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Lanzhou Angeli Biochemical Technology Co., Ltd.

Tel: 0931-8235634 13321316780
Fax: +86(931) 4873122
Email: 1455540579@qq.com
Country: China
ProdList: 958
Advantage: 55

Less

View Lastest Price from BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 18720-35-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-05

Shaanxi Dideu New Materials Co. Ltd

Product: BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER 18720-35-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-11

18720-35-9, BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTERRelated Search:

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid DiMethyl bicyclo[2.2.1]heptane-1,4-carboxylate TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2S-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester 7-(TERT-BUTOXYCARBONYL)-1-OXA-2,7-DIAZASPIRO[4.4]NON-2-ENE-3-CARBOXYLIC ACID DI-2-PYRIDYL THIONOCARBONATE Dibenzyl chloroMethyl phosphate (3aR,6as)-tert-butyl 5-methylenehexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER trans-1,4-Cyclohexanedicarboxybic acid 1,4-Cyclohexanedicarboxylic acid dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

Bicyclo[2.2.2]octane-1,4-dicarboxylIic acid hemimethyl ester

Bicyclo [2.2.2]octane-1,4-dicarboxylic acid, 1-methyl ester

Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, monomethyl ester

4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-

1-Carboxy-4-(Methoxycarbonyl)bicyclo[2.2.2]octane

4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid, >=98%

4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

4-(METHOXYCARBONYL)BICYCLO[2.2.2]OCTANE-1-CARBOXYLICACID

Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, monomethyl ester 97%

4- (methoxy carbonyl) double ring [2.2.2] octane -1- carboxylic acid

Bicyclo[2.2.2]octane-1,4-dicarboxylIic acid hemimethyl este

Bicyclo [2.2.2] octane-1,4-cyclohexanedicarboxylate

o[2.2.2]octane-1-carboxyL

Monomethyl Hydrogen Bicyclo[2.2.2]octane-1,4-dicarboxylate

l)bicyclo[2.2.2]octane-1-carboxylic acid

1-Methyl bicyclo[2.2.2]octane-1,4-dicarboxylate

1-Methyl bicyclo[2.2.2]heptane-1, 4-dicarboxylate

18720-35-9

Carboxylic Acids

Fused Ring Systems