trans-1,4-Cyclohexanedicarboxybic acid
- Product Name
- trans-1,4-Cyclohexanedicarboxybic acid
- CAS No.
- 619-82-9
- Chemical Name
- trans-1,4-Cyclohexanedicarboxybic acid
- Synonyms
- (1r,4r)-cyclohexane-1,4-dicarboxylic acid;TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID;trans-Hexahydro-p-phthalic acid;trans-1,4-Cyclohexanedicarboxyli;TRANS-HEXAHYDROTEREPHTHALIC ACID;rans-1,4-Cyclohexanedicarboxylicaci;Trans-1,4-cyclohexanedicarboxylic cid;trans-1,4-Cyclohexyldicarboxylic acid;trans-1,4-cyclohexanedicarboxybic acid;TRANS-CYCLOHEXAN-1,4-DICARBOXYLIC ACID
- CBNumber
- CB6249999
- Molecular Formula
- C8H12O4
- Formula Weight
- 172.18
- MOL File
- 619-82-9.mol
trans-1,4-Cyclohexanedicarboxybic acid Property
- Melting point:
- >300 °C(lit.)
- Boiling point:
- 262.49°C (rough estimate)
- Density
- 1.2104 (rough estimate)
- refractive index
- 1.4795 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- pK1:4.18 ;pK2:5.42 (16°C)
- color
- White to Almost white
- Water Solubility
- Soluble in hot methanol (almost transparency), ethanol, acetone. Slightly soluble in ether and water
- InChI
- InChI=1S/C8H12O4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h5-6H,1-4H2,(H,9,10)(H,11,12)/t5-,6-
- InChIKey
- PXGZQGDTEZPERC-IZLXSQMJSA-N
- SMILES
- [C@@H]1(C(O)=O)CC[C@@H](C(O)=O)CC1
- CAS DataBase Reference
- 619-82-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,4-Cyclohexanedicarboxylic acid, trans-(619-82-9)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-24/25
- WGK Germany
- 3
- HS Code
- 29172090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C100757
- Product name
- trans-1,4-Cyclohexanedicarboxylic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $160
- Updated
- 2023/01/07
- Product number
- C0475
- Product name
- trans-1,4-Cyclohexanedicarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- C0475
- Product name
- trans-1,4-Cyclohexanedicarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 100g
- Price
- $145
- Updated
- 2025/07/31
- Product number
- C0475
- Product name
- trans-1,4-Cyclohexanedicarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 500g
- Price
- $407
- Updated
- 2025/07/31
- Product number
- T705165
- Product name
- trans-1,4-Cyclohexanedicarboxylic acid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
trans-1,4-Cyclohexanedicarboxybic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
It is a pharmaceutical intermediate.
Definition
ChEBI: 1,4-cyclohexanedicarboxylic acid is a dicarboxylic acid that is cyclohexane substituted by carboxy groups at positions 1 and 4.
Synthesis
100-21-0
619-81-8
The general procedure for the synthesis of cis-1,4-cyclohexanedicarboxylic acid from terephthalic acid is as follows: 200 g of terephthalic acid, 15 g of the Pd-Pt/C catalyst described in Examples 1 to 14 and 1000 g of water were added to an autoclave and stirring was initiated. Three nitrogen purges were first performed, followed by three replacements with hydrogen. The system was pressurized to a hydrogen pressure of 4 MPa and the reaction temperature was kept stable at 200°C, and hydrogen was continuously supplied to the reaction for 3 hours. At the end of the reaction, the catalyst was removed by filtration while hot, and the filtrate was cooled and filtered again to collect the filter cake. The filter cake was dried at 120 °C to obtain the solid product. The solid product was analyzed by liquid chromatography to determine the contents of 1,4-cyclohexanedicarboxylic acid and trans-1,4-cyclohexanedicarboxylic acid therein, from which the yields of 1,4-cyclohexanedicarboxylic acid and the selectivity of trans-1,4-cyclohexanedicarboxylic acid were calculated, and the specific results are shown in Table 2.
References
[1] Patent: CN103769089, 2016, B. Location in patent: Paragraph 0029; 0030
[2] RSC Advances, 2017, vol. 7, # 30, p. 18178 - 18188
[3] Patent: CN105237341, 2016, A. Location in patent: Paragraph 0014
[4] Patent: KR2017/36493, 2017, A. Location in patent: Paragraph 0057; 0058; 0059
[5] Patent: KR2018/35585, 2018, A. Location in patent: Paragraph 0117-0121; 0145; 0146
trans-1,4-Cyclohexanedicarboxybic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from trans-1,4-Cyclohexanedicarboxybic acid manufacturers
- Product
- trans-1,4-Cyclohexanedicarboxybic acid 619-82-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000Tons
- Release date
- 2024-08-05
- Product
- Trans-1,4-cyclohexanedicarboxylic acid 619-82-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21
- Product
- trans-1,4-Cyclohexanedicarboxybic acid 619-82-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27