NOGALAMYCIN

Product Name: NOGALAMYCIN
CAS No.: 1404-15-5
Chemical Name: NOGALAMYCIN
Synonyms: U 15167;U-15167;nsc-70845;noramycin;AIDS031122;NOGALAMYCIN;nogalomycin;Nogalamyicn;Nogalamycine;Nogalamycinum
CBNumber: CB3752063
Molecular Formula: C39H49NO16
Formula Weight: 787.8
MOL File: 1404-15-5.mol

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NOGALAMYCIN Property

Melting point:: 195-196° (dec)
alpha: D25 +425° (c = 0.11 in CHCl3)
Boiling point:: 658.61°C (rough estimate)
Density: 1.2095 (rough estimate)
refractive index: 1.7650 (estimate)
storage temp.: 2-8°C
solubility: DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble
form: A solid
pka: 7.45 (60% ethanol)
color: Orange-red solid from MeOH
biological source: Streptomyces nogalater

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Safety

Hazard Codes: T
Risk Statements: 45-46-61-20/21/22
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: RA4550000
Toxicity: LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27995
Product name: Nogalamycin
Packaging: 5mg
Price: $219
Updated: 2024/03/01

Cayman Chemical

Product number: 27995
Product name: Nogalamycin
Packaging: 25mg
Price: $761
Updated: 2024/03/01

TRC

Product number: N888503
Product name: Nogalamycin
Packaging: 10mg
Price: $1320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009018
Product name: NOGALAMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $500.62
Updated: 2021/12/16

AHH

Product number: MT-57169
Product name: Nogalamycin
Purity: 98%
Packaging: 0.05g
Price: $370
Updated: 2021/12/16

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NOGALAMYCIN Chemical Properties,Usage,Production

Uses

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.

Uses

Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis.

Definition

ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol.

Biochem/physiol Actions

Anthracyclic antitumor antibiotic.

Safety Profile

Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.

NOGALAMYCIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NOGALAMYCIN Suppliers

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1404-15-5, NOGALAMYCINRelated Search:

Amylmetacresol 4-Isobutylbenzaldehyde 5-ISOPROPYL-3-METHYLPHENOL 2-(4-Methylphenyl)propanoic acid NOGALAMYCIN 3-BENZOYLPHENYLACETIC ACID 4-Hexyloxyphenol 1,2,3,4-TETRAHYDRO-2-NAPHTHOL 5,6,7,8-TETRAHYDRO-1-NAPHTHOL 2,5-DIMETHYLPHENYLACETIC ACID 3-HYDROXYPHENYLACETIC ACID METHYL ESTER 2,3-DIMETHYLANTHRAQUINONE 5-ethoxy-2-hydroxy-benzaldehyde 3,4-DIMETHYL-3'-METHOXYBENZOPHENONE 2,5-DIMETHYL-2'-METHOXYBENZOPHENONE (2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-YL)-METHYL-AMINE 2-METHOXY-2'-METHYLBENZOPHENONE 1-(2,4-DIMETHYLPHENYL)ETHANOL

nsc-70845

NOGALAMYCIN, STREPTOMYCES NOGALATER

NOGALAMYCIN

AIDS031122

NOGALAMYCIN FROM STREPTOMYCES NOGALATER

Nogalamycin >=95%, from Streptomyces nogalater

antibiotic205t3

antibioticnsc70845

nogalomycin

Nogalamycine

Nogalamycinum

Nogalamyicn

U 15167

U-15167

2,6-Epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, 11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R,3S,4R,5R,6R,11S,13S,14R)-

noramycin

1404-15-5

C39H49NO16

Antibiotics

Antibiotics A to Z

Antibiotics N-S

BioChemical

Antibiotics

Antibiotics A to

Antibiotics by Application

Antibiotics N-SAntibiotics

Antineoplastic and Immunosuppressive AntibioticsAntibiotics

Inhibits an EnzymeAntibiotics

Interferes with DNA Synthesis

Mechanism of Action