NOGALAMYCIN Property

Melting point:

195-196° (dec)

alpha 

D25 +425° (c = 0.11 in CHCl3)

Boiling point:

658.61°C (rough estimate)

Density 

1.2095 (rough estimate)

refractive index 

1.7650 (estimate)

storage temp. 

2-8°C

solubility 

DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble

form 

A solid

pka

7.45 (60% ethanol)

color 

Orange-red solid from MeOH

Safety

Hazard Codes 

T

Risk Statements 

45-46-61-20/21/22

Safety Statements 

53-22-36/37/39-45

WGK Germany 

3

RTECS 

RA4550000

Toxicity

LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

NOGALAMYCIN Chemical Properties,Usage,Production

Uses

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.

Uses

Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis.

Definition

ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol.

Biochem/physiol Actions

Anthracyclic antitumor antibiotic.

Safety Profile

Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.