2,3-Dihydrobenzo[b]furan-5-carbaldehyde
- Product Name
- 2,3-Dihydrobenzo[b]furan-5-carbaldehyde
- CAS No.
- 55745-70-5
- Chemical Name
- 2,3-Dihydrobenzo[b]furan-5-carbaldehyde
- Synonyms
- 2,3-DIHYDROBENZOFURAN-5-CARBALDEHYDE;AKOS MSC-0772;5-ForMylcouMaran;BUTTPARK 27\04-60;TIMTEC-BB SBB005559;Ramelteon Impurity 31;CouMarancarboxaldehyde;5-Coumarancarboxaldehyde;1-(benzofuran-5-yl)ethanone;2,3-dihyro-1-benzofuran-5-carb
- CBNumber
- CB3762637
- Molecular Formula
- C9H8O2
- Formula Weight
- 148.16
- MOL File
- 55745-70-5.mol
2,3-Dihydrobenzo[b]furan-5-carbaldehyde Property
- Melting point:
- 191～193℃
- Boiling point:
- 88-89 °C/0.1 mmHg (lit.)
- Density
- 1.177 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.6000(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C(protect from light)
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- CAS DataBase Reference
- 55745-70-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 631957
- Product name
- 2,3-Dihydrobenzofuran-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $28.6
- Updated
- 2023/06/20
- Product number
- 631957
- Product name
- 2,3-Dihydrobenzofuran-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $83.5
- Updated
- 2023/06/20
- Product number
- D3857
- Product name
- 2,3-Dihydrobenzofuran-5-carboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- D3857
- Product name
- 2,3-Dihydrobenzofuran-5-carboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $309
- Updated
- 2025/07/31
- Product number
- D448490
- Product name
- 2,3-Dihydrobenzofuran-5-carboxaldehyde
- Packaging
- 2.5g
- Price
- $85
- Updated
- 2021/12/16
2,3-Dihydrobenzo[b]furan-5-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
White to light yellow liquid
Uses
Hair dye composition.
Synthesis
496-16-2
68-12-2
55745-70-5
2,3-Dihydrobenzofuran-5-carbaldehyde was synthesized as follows: in a dry reaction flask, 2,3-dihydrobenzofuran (100 g, 0.833 mol) was dissolved in N,N-dimethylformamide (355.0 ml). Under stirring, phosphorus oxychloride (255.58 g, 1.666 mol) was slowly added dropwise, and the reaction temperature was controlled to be maintained between 80°C and 85°C. The reaction mixture was stirred continuously at this temperature for 4 to 5 hours, during which the progress of the reaction was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the mixture was carefully poured into ice water to quench the reaction. Subsequently, the organic layer was separated by extraction with toluene (2000 ml). The organic layer was washed sequentially with 5% sodium bicarbonate solution (500 ml) and 10% brine solution (500 ml) to remove residual acid and DMF.The washed organic layer was subjected to distillation under reduced pressure at 50 °C to 60 °C to remove the solvent to give the crude product. By further purification, 2,3-dihydrobenzofuran-5-carbaldehyde was obtained in 85% to 90% yield and 90% to 92% purity.
References
[1] Patent: EP1792899, 2007, A1. Location in patent: Page/Page column 11
[2] Patent: WO2010/41271, 2010, A2. Location in patent: Page/Page column 28
[3] Letters in Drug Design and Discovery, 2013, vol. 10, # 7, p. 561 - 571
[4] Patent: CN102766135, 2017, B. Location in patent: Paragraph 0035-0036
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4222 - 4239
2,3-Dihydrobenzo[b]furan-5-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dihydrobenzo[b]furan-5-carbaldehyde manufacturers
- Product
- 2,3-Dihydrobenzo[b]furan-5-carbaldehyde 55745-70-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customise
- Release date
- 2018-08-09