METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE
- Product Name
- METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE
- CAS No.
- 668262-52-0
- Chemical Name
- METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE
- Synonyms
- -5-chlorobenzoate;METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE;2-BROMOMETHYL-5-CHLORO-BENZOIC ACID METHYL ESTER;2-carboxy-4-chloro-broMoMethylbenzene Methyl ester;Benzoic acid, 2-(bromomethyl)-5-chloro-, methyl ester
- CBNumber
- CB3762945
- Molecular Formula
- C9H8BrClO2
- Formula Weight
- 263.52
- MOL File
- 668262-52-0.mol
METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE Property
- Boiling point:
- 331.0±32.0 °C(Predicted)
- Density
- 1.561±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Yellow
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- OR400300
- Product name
- Methyl2-(bromomethyl)-5-chlorobenzoate
- Packaging
- 250mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 2723-D-00
- Product name
- Methyl 2-(bromomethyl)-5-chlorobenzoate
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- OR400300
- Product name
- Methyl2-(bromomethyl)-5-chlorobenzoate
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 2723-D-00
- Product name
- Methyl 2-(bromomethyl)-5-chlorobenzoate
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 119369
- Product name
- Methyl 2-(bromomethyl)-5-chlorobenzoate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE Chemical Properties,Usage,Production
Synthesis
99585-13-4
668262-52-0
General procedure for the synthesis of methyl 2-(bromomethyl)-5-chlorobenzoate from methyl 2-methyl-5-chlorobenzoate: methyl 5-chloro-2-methylbenzoate (10.0 g, 54 mmol), N-bromosuccinimide (NBS, 10.6 g, 59.5 mmol), and azobisisobutyronitrile (AIBN, 200 mg) were dissolved in 1,2-dichloroethane ( 300 mL). The reaction mixture was irradiated and stirred for 2 h under photocatalytic conditions using [PHOTOLAMP]. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with heptane/dichloromethane as eluent (gradient elution: 9:1, 4:1, 1:1) to afford 11.8 g of methyl 2-(bromomethyl)-5-chlorobenzoate (83% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.98 (d, J = 2.1 Hz, 1H), 7.49 (dd, J = 2.2, 8.2 Hz, 1H), 7.43 (d, J = 8.2 Hz, 1H), 4.93 (s, 2H), 3.97 (s, 3H).
References
[1] Patent: WO2004/18414, 2004, A2. Location in patent: Page 112
[2] Patent: WO2005/21508, 2005, A1. Location in patent: Page/Page column 148
[3] Israel Journal of Chemistry, 1971, vol. 9, p. 111 - 118
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 5, p. 1628 - 1631
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 360 - 365
METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE Suppliers
- Tel
- --
- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from METHYL 2-BROMOMETHYL-5-CHLORO-BENZOATE manufacturers
- Product
- Methyl 2-(bromomethyl)-5-chlorobenzoate 668262-52-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09