ChemicalBook > CAS DataBase List > 6-Nitrophthalide

6-Nitrophthalide

Product Name: 6-Nitrophthalide
CAS No.: 610-93-5
Chemical Name: 6-Nitrophthalide
Synonyms: NSC 11332;AKOS 237-80;6-NITROPHTALIDE;6-NITROPHTHALIDE;BUTTPARK 33\04-92;RARECHEM AR PA 0038;6-Nitrophthalide,97%;6-Nitrophthalide, 97% 1GR;6-nitro-3H-2-benzofuran-1-one;6-Nitroisobenzofuran-1(3H)-one
CBNumber: CB3769045
Molecular Formula: C8H5NO4
Formula Weight: 179.13
MOL File: 610-93-5.mol

Less

6-Nitrophthalide Property

Melting point:: 140-145 °C(lit.)
Boiling point:: 311.63°C (rough estimate)
Density: 1.4908 (rough estimate)
refractive index: 1.5160 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Crystalline Powder
color: Pale yellow
Water Solubility: 0.4g/L(25 ºC)
CAS DataBase Reference: 610-93-5(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-37-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29322090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: N1055
Product name: 6-Nitrophthalide
Purity: >95.0%(GC)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: N1055
Product name: 6-Nitrophthalide
Purity: >95.0%(GC)
Packaging: 5g
Price: $87
Updated: 2025/07/31

Matrix Scientific

Product number: 059195
Product name: 6-Nitro-3H-isobenzofuran-1-one
Purity: 95+%
Packaging: 5g
Price: $24
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK553846
Product name: 6-Nitrophthalide
Purity: 97%
Packaging: 1g
Price: $26
Updated: 2021/12/16

ChemScene

Product number: CS-W017285
Product name: 6-Nitroisobenzofuran-1(3H)-one
Purity: 99.57%
Packaging: 25g
Price: $75
Updated: 2021/12/16

Less

6-Nitrophthalide Chemical Properties,Usage,Production

Chemical Properties

pale yellow crystalline powder

Uses

6-Nitrophthalide is a fluorescent heterocycle that can be used as a probe for specific inhibition. It is homologous to other fluorescent probes such as fluorescein, nitrobenzene, and nitrophenol. It has been shown to have inhibitory properties against triazole and dipole, which are catalytic asymmetric. 6-Nitrophthalide has also been shown to have the ability to inhibit the oxidation of aldehydes.

Preparation

6-Nitrophthalide is synthesized from 2-nitrobenzaldehyde via a two-step process, and then reacted with methyl iodide.

Application

6-Nitrophthalide has been used in the preparation of 3-bromo-6-nitrophthalide. It undergoes reductive methylation to form 6-dimethylaminophthalide.

Synthesis

87-41-2

610-93-5

Step A: Synthesis of 6-nitrobenzofuran-1(3H)-one 1. dissolve phthalide (40.0 g, 298 mmol) in sulfuric acid (50.0 mL) under ice bath conditions and stir until homogeneous. 2. dissolve potassium nitrate (30.4 g, 300 mmol) in sulfuric acid (80 mL) and add to the above sulfuric acid solution of phthalide by dropping. 3. Keeping the reaction mixture under stirring, the reaction mixture was slowly warmed up to room temperature, which took about 5 hours. 4. Upon completion of the reaction, the mixture was slowly poured into ice water to precipitate. 5. The precipitate was collected and recrystallized from ethanol (3 L) to give 6-nitrobenzofuran-1(3H)-one (50.4 g, 94% yield) as an off-white solid. 6. The structure and purity (98%) of the product were confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 500 MHz, CDCl3) with the following characteristic peaks: δ 8.77 (d, J = 1.5 Hz, 1H), 8.58 (dd, J = 8.5, 2.0 Hz, 1H), 7.72 (d, J = 8.5 Hz, 1H), 5.45 (s, 2H).

References

[1] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[2] Patent: WO2012/142459, 2012, A1. Location in patent: Page/Page column 37
[3] Journal of Heterocyclic Chemistry, 1992, vol. 29, # 6, p. 1519 - 1523
[4] Patent: US2008/9524, 2008, A1. Location in patent: Page/Page column 409
[5] Patent: US2011/98311, 2011, A1

6-Nitrophthalide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

6-Nitrophthalide Suppliers

Americas 1 Belgium 3 China 78 Europe 1 France 1 Germany 8 India 5 Japan 3 Slovakia 1 Switzerland 3 United Kingdom 17 United States 21 Global 142

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

ChangZhou SIDU chemical Co., Ltd.

Tel: 0519-81291281 18015082300
Fax: 0519-81291281
Email: siduchem@hotmail.com
Country: China
ProdList: 274
Advantage: 62

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Nanjing Credit Trading Co.,Ltd

Tel: 025-52164950
Fax: 025-86800069
Email: Googlexu_0114@sina.com
Country: China
ProdList: 644
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9986
Advantage: 58

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Chongqing AoShe Biological Chemical Co., Ltd.

Tel: 023-63225655 13320248848
Fax: 023-63225655QQ2366581735
Email: 2366581735@qq.com
Country: China
ProdList: 511
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

JiangYin Ruisheng Chemical Co., Ltd.

Tel: 13003356808
Fax: QQ:1485751188
Email: 1485751188@qq.com
Country: China
ProdList: 403
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Guangzhou Jhd Chemical Reagent Co., Ltd.

Tel: 020-84383047
Fax: 020-84380294
Email: sales@jhd.com.cn
Country: China
ProdList: 9186
Advantage: 65

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Shanghai aokun chemical technology co., LTD

Tel: 13482267656
Fax: 13482267656
Email: 3453343871@qq.com
Country: China
ProdList: 206
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Nantong Haigine Pharma Technology Co., Ltd

Tel: 0086-513-86266699
Fax: 0086-513-86855116
Country: CHINA
ProdList: 156
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Shanghai Hongshun Biological Technology Co., Ltd.

Tel: 15901914505 15901914505;
Fax: 021-54389085
Email: 3187892335@qq.com
Country: China
ProdList: 9889
Advantage: 58

Zhengzhou Edward Biology Co.,Ltd

Tel: 0371-63682289 15538176268
Fax: QQ：1875164801
Email: jacschem@163.com
Country: China
ProdList: 9926
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569262 +86-15003564040
Fax: 029-88380327
Email: 1087@dideu.com
Country: China
ProdList: 3979
Advantage: 58

NORANA GROUP

Tel: 027-59209883 17386138556
Email: service@nornachem.com
Country: China
ProdList: 4942
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Ningbo jinuo chemical co., LTD

Tel: 0574-87314919 057487319282
Email: info@nbinno.com
Country: China
ProdList: 7047
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

610-93-5, 6-NitrophthalideRelated Search:

1,2,4,5-Tetrachlorobenzene 3-Nitrobenzaldehyde 4-(4-NITROPHENYL)MORPHOLINE Phthalide FTHALIDE 4-Nitrophthalide 5 NITROPHTHALIDE 4,5,6-triethoxy-7-nitrophthalide 6-NITRO-3-PHENYL-3H-ISOBENZOFURAN-1-ONE 6-Nitrophthalide 5-CHLORO-3-HYDROXY-6-NITRO-3H-ISOBENZOFURAN-1-ONE NITROFLUORESCEIN, ISOMER 1 4-Nitrophthalic anhydride

RARECHEM AR PA 0038

6-NITRO-1,3-DIHYDROISOBENZOFURAN-1-ONE

6-NITRO-3H-ISOBENZOFURAN-1-ONE

6-NITROPHTALIDE

6-NITROPHTHALIDE

BUTTPARK 33\04-92

6-Nitrophthalide,97%

AKOS 237-80

6-Nitrophthalide, 97% 1GR

6-nitro-3H-2-benzofuran-1-one

6-Nitroisobenzofuran-1(3H)-one

6-Nitro-1(3H)-isobenzofuranone

NSC 11332

2-[(E)-2-(4-quinolinyl)ethenyl]aniline

1(3H)-Isobenzofuranone, 6-nitro-

610-93-5

O2NC6H3COOCH2

Lactones

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Phthalides

Carbonyl Compounds

Lactones

Organic Building Blocks