4-Bromothiophene-2-carboxaldehyde
- Product Name
- 4-Bromothiophene-2-carboxaldehyde
- CAS No.
- 18791-75-8
- Chemical Name
- 4-Bromothiophene-2-carboxaldehyde
- Synonyms
- 4-BROMOTHIOPHENE-2-CARBALDEHYDE;4-BROMO-2-THIOPHENECARBOXALDEHYDE;TIMTEC-BB SBB000293;4-Bromo-2-thiophene;LABOTEST-BB LT00112358;4-BROMO-2-FORMYLTHIOPHENE;3-Bromo-5-formylthiophene;4-BROMOTHIOPHENE-2-ALDEHYDE;4-Bromthiophen-2-carbaldehyd;4-BROMO-2-THIOPHENECARBALDEHYDE
- CBNumber
- CB3771198
- Molecular Formula
- C5H3BrOS
- Formula Weight
- 191.05
- MOL File
- 18791-75-8.mol
4-Bromothiophene-2-carboxaldehyde Property
- Melting point:
- 44-46 °C (lit.)
- Boiling point:
- 114-115 °C/11 mmHg (lit.)
- Density
- 1.770 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- Powder or Granules
- color
- White to beige
- Sensitive
- Air Sensitive
- BRN
- 108455
- InChI
- InChI=1S/C5H3BrOS/c6-4-1-5(2-7)8-3-4/h1-3H
- InChIKey
- PDONIKHDXYHTLS-UHFFFAOYSA-N
- SMILES
- C1(C=O)SC=C(Br)C=1
- CAS DataBase Reference
- 18791-75-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 22-24/25-36/37/39-26-36
- WGK Germany
- 3
- F
- 10-23
- TSCA
- N
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 283452
- Product name
- 4-Bromo-2-thiophenecarboxaldehyde
- Purity
- 90%
- Packaging
- 5g
- Price
- $56.3
- Updated
- 2025/07/31
- Product number
- 283452
- Product name
- 4-Bromo-2-thiophenecarboxaldehyde
- Purity
- 90%
- Packaging
- 25g
- Price
- $186.9
- Updated
- 2025/07/31
- Product number
- B2827
- Product name
- 4-Bromothiophene-2-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- B2827
- Product name
- 4-Bromothiophene-2-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- B688110
- Product name
- 4-Bromo-2-thiophenecarboxaldehyde
- Packaging
- 50g
- Price
- $1230
- Updated
- 2021/12/16
4-Bromothiophene-2-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Bromothiophene-2-carboxaldehyde has been used:
- as building block for the synthesis of tetrahydroisoquinolinones
- in the synthesis of 3-[(4-bromo-2-thienyl)methylenehydrazinocarbonyl]-1H-1,2,4-triazole
Application
4-Bromothiophene-2-carboxaldehyde is an important and commonly used intermediate in medicinal chemistry.
Synthesis
872-31-1
68-12-2
18791-75-8
930-96-1
General procedure: a THF solution of 1 M NaHMDS (8.8 mL, 8.8 mmol) was slowly added dropwise to the substrate (6.8 mmol) at 0°C. The reaction mixture was stirred for 30 min at 0 °C, then a solution of anhydrous THF (2 mL) with electrophilic reagent (8.3 mmol) was slowly added and stirring was continued for 3 h at 0 °C. Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution (5 mL) and diluted with hexane (20 mL). The organic layer was separated and washed with 15 wt% NaCl aqueous solution (10 mL) and subsequently concentrated to give the crude product. The product was purified by fast chromatography using a silica gel column pretreated with Et3N and 0.1% Et3N/4.9% EtOAc/95% hexane as eluent.
Toxicity evaluation
4-Bromothiophene-2-carboxaldehyde has acute oral toxicity and acute dermal toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.
References
[1] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169
[2] Tetrahedron Letters, 2012, vol. 53, # 2, p. 166 - 169
4-Bromothiophene-2-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromothiophene-2-carboxaldehyde manufacturers
- Product
- 4-BroMo-2-thiophenecarboxaldehyde 18791-75-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- 4-Bromothiophene-2-carboxaldehyde 18791-75-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-09
- Product
- 4-Bromothiophene-2-carboxaldehyde 18791-75-8
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-19